Mitigating inflammation and fibrosis: the therapeutic potential of quercetin liposomes in COPD DOI Creative Commons

Changfeng Yin,

Yushan Tian, Yan An

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 17, 2024

Chronic obstructive pulmonary disease (COPD) is a with severe therapeutic obstacles and high worldwide death rate. COPD progresses predominantly through inflammatory response followed by fibrotic destruction. Quercetin (Que), recognized for its anti-inflammatory effects, presents significant promise as candidate therapy. However, poor water solubility low bioavailability of Que hinder further clinical application. Liposomes are renowned their unique structure function, which provided an efficient approach the delivery in various drug systems. This study was aim to prepare novel liposome (Que-lipo) administrated via intratracheal (i.t.) cigarette smoke induced mice. The underlying mechanisms against lung damage Que-lipo were explored.

Language: Английский

Aspirin-triggered RvD1 (AT-RvD1) modulates epithelial-mesenchymal transition on bronchial epithelial cells stimulated with cigarette smoke extract DOI
Aline Beatriz Mahler Pereira,

Bethânia Alves Gontijo,

Sarah Cristina Sato Vaz Tanaka

et al.

Prostaglandins & Other Lipid Mediators, Journal Year: 2025, Volume and Issue: unknown, P. 106968 - 106968

Published: Feb. 1, 2025

Language: Английский

Citations

0
Nebulized mesenchymal stem cell-derived exosomes attenuate airway inflammation in a rat model of chronic obstructive pulmonary disease DOI
Min Wang, Yuxin Hao, Wei He

et al.

Cellular Immunology, Journal Year: 2025, Volume and Issue: 409-410, P. 104933 - 104933

Published: Feb. 27, 2025

Language: Английский

Citations

0
Mitigating inflammation and fibrosis: the therapeutic potential of quercetin liposomes in COPD DOI Creative Commons

Changfeng Yin,

Yushan Tian, Yan An

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 17, 2024

Chronic obstructive pulmonary disease (COPD) is a with severe therapeutic obstacles and high worldwide death rate. COPD progresses predominantly through inflammatory response followed by fibrotic destruction. Quercetin (Que), recognized for its anti-inflammatory effects, presents significant promise as candidate therapy. However, poor water solubility low bioavailability of Que hinder further clinical application. Liposomes are renowned their unique structure function, which provided an efficient approach the delivery in various drug systems. This study was aim to prepare novel liposome (Que-lipo) administrated via intratracheal (i.t.) cigarette smoke induced mice. The underlying mechanisms against lung damage Que-lipo were explored.

Language: Английский

Citations

1