The host genotype actively shapes its microbiome across generations in laboratory mice DOI Creative Commons
Laurentiu Benga, Anna Rehm,

Christina Gougoula

et al.

Microbiome, Journal Year: 2024, Volume and Issue: 12(1)

Published: Dec. 5, 2024

Abstract Background The microbiome greatly affects health and wellbeing. Evolutionarily, it is doubtful that a host would rely on chance alone to pass microbial colonization its offspring. However, the literature currently offers only limited evidence regarding two alternative hypotheses: active shaping by genetic factors or transmission of maternal legacy. Results To further dissect influence genetics inheritance, we collected two-cell stage embryos from representative wild types, C57BL6/J BALB/c, transferred mixture both genotype into hybrid recipient mice be inoculated an identical at birth. Conclusions Observing offspring for six generations unequivocally emphasizes impact over legacy in constant environments, akin murine laboratory experiments. Interestingly, solely controlled first generation. current supporting has not extended beyond this initial generation, resolving aforementioned debate. Graphical

Language: Английский

Personalized COPD Care: The Future of Precision-Based Therapies DOI Open Access

Leslie K. Appleton,

Nicola A. Hanania, Muhammad Adrish

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(21), P. 6339 - 6339

Published: Oct. 23, 2024

Chronic obstructive pulmonary disease (COPD) is a progressive respiratory illness characterized by long-standing symptoms and airflow limitation. It major contributor to disease-related deaths currently ranked as the sixth leading cause of mortality in United States. Approved pharmacological therapies for stable primarily consist inhaled short long-acting bronchodilators, corticosteroids, azithromycin, roflumilast. In recent years, significant progress has been made management COPD through identification different phenotypes endotypes, which allows more personalized treatment approach. While earlier studies investigating targeted were less promising, data on drugs targeting type 2 inflammatory pathways have shown promising results carefully selected patients. this article, we will review available well ongoing clinical novel COPD. Understanding implementing these advancements hold promise improving outcomes quality life individuals living with

Language: Английский

Citations

2
Functions and regulations of insect gut bacteria DOI
Shuncai Han, Muhammad Akhtar, Xiaofeng Xia

et al.

Pest Management Science, Journal Year: 2024, Volume and Issue: 80(10), P. 4828 - 4840

Published: June 17, 2024

Abstract The insect gut is a complicated ecosystem that inhabits large number of symbiotic bacteria. As an important organ the host insect, bacteria play very roles in regulating physiological and metabolic processes. Recently, much progress has been made study guts with development high‐throughput sequencing technology molecular biology. This review summarizes primary functions guts, such as enhancing insecticide resistance, facilitating food digestion, promoting detoxification, mating behavior egg hatching. It also addresses some possible pathways symbiont regulation governed by external habitats, conditions immunity insect. provides solid foundations for further studies on novel theories, new technologies practical applications guts. © 2024 Society Chemical Industry.

Language: Английский

Citations

1
The host genotype actively shapes its microbiome across generations DOI Creative Commons
Laurentiu Benga, Anna Rehm,

Christina Gougoula

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: March 15, 2024

Abstract Background The microbiome greatly affects health and wellbeing. Evolutionarily, it is doubtful that a host would rely on chance alone to pass microbial colonization its offspring. However, the literature currently offers only limited evidence regarding two alternative hypotheses: active shaping by genetic factors or transmission of maternal legacy. Results To further dissect influence genetics inheritance, we collected 2-cell stage embryos from representative wildtypes, C57BL6/J BALB/c, transferred mixture both genotype into hybrid recipient mice be inoculated an identical at birth. Conclusions Observing offspring for six generations unequivocally emphasizes impact over legacy in constant environments, akin murine laboratory experiments. Interestingly, solely controlled first generation. current supporting has not extended beyond this initial generation, resolving aforementioned debate. graphical abstract

Language: Английский

Citations

0
The host genotype actively shapes its microbiome across generations in laboratory mice DOI Creative Commons
Laurentiu Benga, Anna Rehm,

Christina Gougoula

et al.

Microbiome, Journal Year: 2024, Volume and Issue: 12(1)

Published: Dec. 5, 2024

Abstract Background The microbiome greatly affects health and wellbeing. Evolutionarily, it is doubtful that a host would rely on chance alone to pass microbial colonization its offspring. However, the literature currently offers only limited evidence regarding two alternative hypotheses: active shaping by genetic factors or transmission of maternal legacy. Results To further dissect influence genetics inheritance, we collected two-cell stage embryos from representative wild types, C57BL6/J BALB/c, transferred mixture both genotype into hybrid recipient mice be inoculated an identical at birth. Conclusions Observing offspring for six generations unequivocally emphasizes impact over legacy in constant environments, akin murine laboratory experiments. Interestingly, solely controlled first generation. current supporting has not extended beyond this initial generation, resolving aforementioned debate. Graphical

Language: Английский

Citations

0