Alteration in Tracheal Morphology and Transcriptomic Features in Calves After Infection with Mycoplasma bovis

Microorganisms, Journal Year: 2025, Volume and Issue: 13(2), P. 442 - 442

Published: Feb. 18, 2025

Mycoplasma bovis is one of the most important pathogens in animal husbandry, and current infection morbidity rates are increasing year by year, causing great losses to farming industry seriously affecting welfare. In this study, we took tracheal tissues from calves infected with M. make pathological tissue sections for observation, selected transcriptome sequencing screen differentially expressed genes based on threshold |log2FoldChange| > 1 Padjust < 0.05 functional enrichment, explore depth potential mechanisms bovine damage caused tracheitis. Experiments were conducted observe changes after through trachea bovis-infected calves. From results, mined main differential metabolic pathways It was found that cricoid cartilage congested hemorrhagic calves, showed localized necrosis epithelial cells, disorganization, high inflammatory cell infiltration interepithelial lamina propria, some detachment. Transcriptome identified 4199 DEGs, including 1378 up-regulated 2821 down-regulated genes. KEGG enrichment analysis indicated enriched 59 significantly differing signaling pathways, a number related tracheitis induced unearthed. The major ones included IL-17, Toll-like receptor, JAK/STAT, PI3K-Akt pathway, etc. trachea, results also significant differences expression key such as IL-6 factor, CASP8, APOA1.

Language: Английский

Exploring Ferroptosis in Allergic Inflammatory Diseases: Emerging Mechanisms and Therapeutic Perspectives

Cell Biology International, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

ABSTRACT Ferroptosis, a unique form of regulated cell death driven by iron accumulation and lipid peroxidation, has emerged as critical process in various diseases. Recent evidence suggests its involvement the pathogenesis allergic diseases, including asthma, rhinitis, atopic dermatitis. These conditions are characterized chronic inflammation, oxidative stress, immune dysregulation, all which intersect with molecular mechanisms ferroptosis. Key regulators, such glutathione peroxidase 4 (GPX4), cystine/glutamate antiporter system Xc‐, metabolism pathways, play pivotal roles ferroptotic processes their contribution to disease progression. This review explores mechanistic link between ferroptosis emphasizing how damage overload exacerbate inflammation tissue injury. We also highlight emerging diagnostic biomarkers, peroxidation products could improve monitoring stratification. Therapeutic strategies targeting ferroptosis, GPX4 activators, chelators, inhibitors, show promise preclinical\ studies, offering potential new avenues for treating However, challenges remain translating these findings into clinical applications. By integrating current knowledge, this underscores need further research both biomarker therapeutic target

Language: Английский