Cancers,
Journal Year:
2022,
Volume and Issue:
14(5), P. 1336 - 1336
Published: March 4, 2022
The
molecular
mechanism
of
action
and
the
individual
influence
various
metabolic
pathways
related
to
metformin
intervention
are
under
current
investigation.
available
data
suggest
that
provides
many
advantages,
exhibiting
anti-inflammatory,
anti-cancer,
hepatoprotective,
cardioprotective,
otoprotective,
radioprotective,
radio-sensitizing
properties
depending
on
cellular
context.
This
literature
review
was
undertaken
provide
novel
evidence
concerning
intervention,
with
a
particular
emphasis
cancer
treatment
prevention.
Undoubtedly,
pleiotropic
actions
associated
include
inhibiting
inflammatory
processes,
increasing
antioxidant
capacity,
improving
glycemic
lipid
metabolism.
Consequently,
these
characteristics
make
an
attractive
medicament
translate
human
trials,
promising
results
which
were
also
summarized
in
this
review.
Combination
of
current
antidiabetic
agents
with
natural
antioxidants
to
manage
diabetes
mellitus
and
its
complications
has
appeared
as
an
emerging
trend.
Curcumin,
a
yellow
pigment
isolated
from
Curcuma
longa
rhizomes,
gained
attention
due
beneficial
effects
in
controlling
the
disturbances
observed
mellitus.
The
purpose
this
study
was
investigate
if
yoghurt
enriched
curcumin
metformin,
individually
or
mixtures,
ameliorates
physiometabolic
parameters,
glycoxidative
stress
biomarkers,
paraoxonase
1
(PON
1)
activity
diabetic
rats.
Streptozotocin-diabetic
rats
(6-week-old
Wistar
rats)
were
treated
for
30
days
mixtures
(10
rats/group).
After
treatments,
plasma
levels
glucose,
triacylglycerol,
cholesterol,
thiobarbituric
acid
reactive
substances
(TBARS,
biomarker
lipid
oxidation),
fluorescent
advanced
glycation
end
products
(AGEs),
PON
1,
antioxidant
enzyme
assessed.
Data
analyzed
using
one-way
analysis
variance
(ANOVA)
followed
by
Student–Newman–Keuls
test.
Treatment
metformin
alone
decreased
TBARS,
AGEs,
well
increased
1.
combination
further
dyslipidemia
TBARS
rats,
indicating
synergy,
maintained
high
These
findings
indicated
that
combined
may
act
synergistically
on
oxidative
stress,
levels.
Therefore,
it
might
be
promising
strategy
combating
complications,
mainly
cardiovascular
events.
Journal of Functional Foods,
Journal Year:
2020,
Volume and Issue:
75, P. 104203 - 104203
Published: Sept. 23, 2020
Ageing
is
an
emerging
global
public
health
concern
due
to
the
increasing
number
of
elderly
people
and
ageing-related
degenerative
disorders.
Given
absence
effective
treatments
manage
diseases,
efforts
have
been
directed
find
ways
reduce
risk
developing
these
Among
them,
plant
phytochemicals,
such
as
phenolic
compounds,
are
considered
potential
anti-ageing
agents
their
multifaceted
biochemical
actions.
In
this
review,
we
focus
on
presenting
results
last
few
years
pioneer
researches
mainly
with
animal
models
human
trials
showing
key
role
compounds
agents.
Recent
advances
demonstrated
that
several
can
and/or
delay
disorders,
including
neurodegenerative
metabolic
syndromes,
cancers
particularly
by
modulating
signalling
pathways
involved
in
inflammation,
oxidative
damage,
autophagy,
apoptosis.
Therefore,
be
a
complementary
alternative
tool
for
managing
diseases.
Cardiovascular Diabetology,
Journal Year:
2019,
Volume and Issue:
18(1)
Published: Jan. 28, 2019
Increasing
evidence
has
suggested
that
the
presence
of
remnant
lipoproteins
is
a
significant
risk
factor
for
atherosclerosis.
Remnant
are
rich
in
triglycerides
(TGs),
and
main
components
include
very-low-density
lipoprotein
(VLDL)
fasting
state.
Diabetic
patients
often
have
hypertriglyceridemia
with
elevated
levels
VLDL
cholesterol
but
normal
low-density
(LDL-C).
The
aim
present
study
was
to
elucidate
potential
role
lipoproteins-induced
atherosclerosis
occurrence
development
in-stent
restenosis
(ISR)
diabetic
coronary
artery
disease.
enrolled
2312
type
2
diabetes
mellitus
who
underwent
percutaneous
intervention
from
January
2013
December
2014
were
followed
up
by
angiography.
Patients
divided
into
two
groups
based
on
or
absence
ISR,
multivariate
Cox’s
proportional
hazards
regression
modelling
showed
remnant-like
particle
(RLP-C)
an
independent
ISR.
According
receiver
operating
characteristic
curve,
optimal
cutoff
point
RLP-C
identified,
further
groups.
Propensity
score
matching
analysis
performed,
762
pairs
successfully
matched.
Log-rank
tests
used
compare
Kaplan–Meier
curves
overall
follow-up
assess
independently
associated
baseline
level
at
0.505
mmol/L
identified
as
predict
RLP
levels.
After
propensity
analysis,
total
matched
generated.
estimated
cumulative
rate
ISR
significantly
higher
≥
(log-rank
P
<
0.001;
HR
equal
4.175,
95%
CI
=
3.045–5.723,
0.001)
compared
mmol/L.
emphasized
importance
cardiovascular
pathology
patients.
Physicians
should
take
measures
control
below
better
prevent
Cancers,
Journal Year:
2022,
Volume and Issue:
14(5), P. 1336 - 1336
Published: March 4, 2022
The
molecular
mechanism
of
action
and
the
individual
influence
various
metabolic
pathways
related
to
metformin
intervention
are
under
current
investigation.
available
data
suggest
that
provides
many
advantages,
exhibiting
anti-inflammatory,
anti-cancer,
hepatoprotective,
cardioprotective,
otoprotective,
radioprotective,
radio-sensitizing
properties
depending
on
cellular
context.
This
literature
review
was
undertaken
provide
novel
evidence
concerning
intervention,
with
a
particular
emphasis
cancer
treatment
prevention.
Undoubtedly,
pleiotropic
actions
associated
include
inhibiting
inflammatory
processes,
increasing
antioxidant
capacity,
improving
glycemic
lipid
metabolism.
Consequently,
these
characteristics
make
an
attractive
medicament
translate
human
trials,
promising
results
which
were
also
summarized
in
this
review.
