Cardiovascular Diabetology,
Journal Year:
2023,
Volume and Issue:
22(1)
Published: Jan. 10, 2023
Abstract
Background
Previous
researches
on
large
animal
models
of
diabetic
cardiomyopathy
were
insufficient.
The
aim
this
study
was
to
evaluate
early
changes
in
left
ventricular
(LV)
function
and
morphology
pigs
using
a
cardiac
magnetic
resonance
(CMR)
time-volume
curve
feature
tracking
technique.
Methods
Streptozotocin
(STZ)
used
induce
sixteen
pigs.
3.0T
MRI
scanned
the
pig’s
heart
before
2,
6,
10
16
months
after
modelling.
CMR
biomarkers,
including
myocardial
strain,
compared
analyse
longitudinal
LV
morphology.
Pearson
correlation
relationship
between
strain
remodelling.
Cardiac
specimens
obtained
at
10,
modelling
observe
ultrastructural
microstructure
different
courses
diabetes.
Results
Twelve
developed
80%
diastolic
volume
recovery
rate
(DVR)
6
significantly
higher
than
that
(0.78
±
0.08vs.
0.67
0.15).
global
peak
(GLPS)
(−
10.21
3.15
vs.
−
9.74
2.78
9.38
3.71
8.71
2.68
6.59
2.90%)
altered
gradually
from
baseline
data
After
modelling,
remodelling
index
(LVRI)
increased
with
(2.19
0.97
1.36
0.45
g/ml).
LVRI
correlated
(r=
0.40
0.54),
GLPS
being
most
significant.
Electron
microscopy
Masson
staining
showed
damage
fibrosis
progression
disease.
Conclusion
Intravenous
injection
STZ
can
porcine
model,
mainly
characterized
by
decreased
accompanied
biomarkers
could
reflect
injury
cardiomyopathy.
World Journal of Cardiology,
Journal Year:
2025,
Volume and Issue:
17(4)
Published: April 21, 2025
Heart
failure
(HF)
is
a
growing
public
health
concern,
with
an
increasing
incidence
among
younger
populations.
Traditionally,
HF
was
considered
condition
primarily
affecting
the
elderly,
but
of
late,
emerging
evidence
hints
at
rapidly
rising
in
youth
past
2
decades.
has
been
linked
to
complex
interaction
between
risk
factors,
such
as
metabolic
syndrome,
environmental
exposures,
genetic
predispositions,
and
lifestyle
behaviors.
This
review
examines
these
evolving
determinants,
including
substance
abuse,
autoimmune
diseases,
long-term
cardiovascular
effects
coronavirus
disease
2019,
which
disproportionately
affect
individuals.
Through
comprehensive
analysis,
study
highlights
importance
early
detection,
targeted
prevention
strategies,
multidisciplinary
management
approaches
address
this
alarming
trend.
Promoting
awareness
integrating
age-specific
interventions
could
significantly
reduce
burden
improve
outcomes
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: March 27, 2024
Abstract
There
is
a
scarcity
of
information
on
the
population
with
diabetes
mellitus
type
2
and
cardiomyopathy
(PDMC)
in
COVID-19,
especially
association
between
anti-diabetic
medications
COVID-19
outcomes.
Study
designed
as
retrospective
cohort
analysis
covering
2020
2021.
Data
from
National
Diabetes
Registry
(CroDiab)
were
linked
to
hospital
data,
primary
healthcare
SARS-CoV-2
vaccination
database,
test
results
database.
outcomes
cumulative
incidence
positivity,
hospitalizations,
deaths.
For
outcome
predictors,
logistic
regression
models
developed.
Of
231
796
patients
14
485
had
cardiomyopathy.
The
two2-year
all
three
studies'
was
higher
PDMC
than
general
(positivity
15.3%
vs.
14.6%,
p
=
0.01;
hospitalization
7.8%
4.4%,
<
0.001;
death
2.6%
1.2%,
0.001).
Sodium-Glucose
Transporter
(SGLT-2)
inhibitors
therapy
found
be
protective
infections
[OR
0.722
(95%
CI
0.610–0.856)]
hospitalizations
0.555
0.418–0.737)],
sulfonylureas
risk
factors
for
1.184
1.029–1.362)]
insulin
factor
1.261
1.046–1.520)]
1.431
1.080–1.897)].
are
at
greater
acquiring
infection
having
worse
diabetic
population.
SGLT-2
against
hospitalization,
sulfonylurea
factor,
while
Further
research
needed
this
sub-population.
Cardiovascular Diabetology,
Journal Year:
2023,
Volume and Issue:
22(1)
Published: Jan. 10, 2023
Abstract
Background
Previous
researches
on
large
animal
models
of
diabetic
cardiomyopathy
were
insufficient.
The
aim
this
study
was
to
evaluate
early
changes
in
left
ventricular
(LV)
function
and
morphology
pigs
using
a
cardiac
magnetic
resonance
(CMR)
time-volume
curve
feature
tracking
technique.
Methods
Streptozotocin
(STZ)
used
induce
sixteen
pigs.
3.0T
MRI
scanned
the
pig’s
heart
before
2,
6,
10
16
months
after
modelling.
CMR
biomarkers,
including
myocardial
strain,
compared
analyse
longitudinal
LV
morphology.
Pearson
correlation
relationship
between
strain
remodelling.
Cardiac
specimens
obtained
at
10,
modelling
observe
ultrastructural
microstructure
different
courses
diabetes.
Results
Twelve
developed
80%
diastolic
volume
recovery
rate
(DVR)
6
significantly
higher
than
that
(0.78
±
0.08vs.
0.67
0.15).
global
peak
(GLPS)
(−
10.21
3.15
vs.
−
9.74
2.78
9.38
3.71
8.71
2.68
6.59
2.90%)
altered
gradually
from
baseline
data
After
modelling,
remodelling
index
(LVRI)
increased
with
(2.19
0.97
1.36
0.45
g/ml).
LVRI
correlated
(r=
0.40
0.54),
GLPS
being
most
significant.
Electron
microscopy
Masson
staining
showed
damage
fibrosis
progression
disease.
Conclusion
Intravenous
injection
STZ
can
porcine
model,
mainly
characterized
by
decreased
accompanied
biomarkers
could
reflect
injury
cardiomyopathy.
