Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 17, 2025
Remnant
cholesterol
(RC)
has
emerged
as
a
novel
therapeutic
target
beyond
low-destiny-lipoproteins
(LDL-c).
While
elevated
RC
levels
are
strongly
associated
with
cardiovascular
disease
risk
in
the
general
population,
their
specific
role
young-onset
acute
myocardial
infarction
(AMI)
among
patients
type
2
diabetes
mellitus
(T2DM)
remains
insufficiently
explored
and
warrants
further
investigation.
This
retrospective
study
included
AMI
T2DM
admitted
to
First
Affiliated
Hospital
of
Xi'an
Jiaotong
University
from
2018
2022.
Patients
were
stratified
into
tertiles
according
compared
using
thresholds
derived
commanded
values
PREDIMED
cohort
study.
The
primary
outcome
was
AMI.
Group
differences
analyzed
chi-square
test
Kruskal-Wallis
H
test,
while
Spearman
correlation
analyses
assessed
relationships
between
variables.
Univariate
multivariate
logistic
regression
employed
evaluate
association
Among
2,514
participants
(mean
age
61.58
±
11.15
years),
802
(31.9%)
had
increase
increased
significantly
rising
(27.0%
vs
29.7%
39.1%,
P
<
0.001).
showed
significant
positive
total
(TC,
r
=
0.497,
0.001),
triglycerides
(TG,
0.411,
LDL-c
(r
0.166,
independently
higher
(OR:
1.579;
95%
CI:
1.354-1.842;
even
after
adjusting
for
other
traditional
factors
1.415;
CI
1.189-1.684;
Notably,
remained
linked
regardless
whether
within
desired
range.
is
independent
factor
patients,
irrespective
level.
These
findings
underscore
importance
monitoring
managing
clinical
practice
mitigate
this
population.
Genes,
Journal Year:
2025,
Volume and Issue:
16(2), P. 157 - 157
Published: Jan. 26, 2025
Background:
Despite
the
widespread
use
of
lipid-lowering
agents,
risk
atherosclerotic
cardiovascular
disease
(ASCVD)
remains;
this
residual
has
been
attributed
to
remnant
cholesterol
(RC)
levels.
However,
causal
associations
between
RC
levels
and
various
atherosclerosis-related
cardiometabolic
vascular
factors
for
ASCVD
remain
unclear.
Methods:
Using
genetic
biochemical
data
108,876
Taiwan
Biobank
study
participants,
follow-up
31,790
imaging
18,614
we
conducted
a
genome-wide
association
study,
Functional
Mapping
Annotation
analysis,
bidirectional
Mendelian
randomization
analyses
identify
determinants
factors.
Results:
We
found
that
higher
were
associated
with
prevalence
or
incidence
analyzed
The
unveiled
61
lead
variants
determining
analysis
revealed
21
gene
sets
exhibiting
strong
enrichment
signals
lipid
metabolism.
Standard
models
adjusted
nonlipid
variables
low-density
lipoprotein
unraveled
forward
diabetes
mellitus,
hypertension,
microalbuminuria,
metabolic
liver
disease.
Reverse
mellitus
Conclusions:
levels,
mainly
influenced
by
genes
metabolism,
exhibit
factors,
including
This
provides
further
insights
into
role
in
predicting
ASCVD.
Type
2
diabetes
(T2DM)
is
known
to
have
detrimental
effects
on
renal
health.
Our
study
aimed
investigate
the
relationship
between
remnant
cholesterol
(remnant-C)
and
adverse
outcomes
in
patients
with
T2DM.
We
utilized
data
from
Action
Control
Cardiovascular
Risk
Diabetes
(ACCORD)
trial,
which
included
10,196
participants
T2DM
remnant-C
by
performing
Kaplan-Meier
survival
analysis,
Cox
proportional
regression
Restricted
cubic
spline
(RCS)
analysis.
Finally,
several
sensitivity
analyses
were
conducted
assess
robustness
of
our
findings.
Over
a
7-year
follow-up
period,
2039
(23.2%)
developed
albuminuria,
5824
(57.1%)
experienced
worsening
function,
280
(2.7%)
progressed
failure.
After
adjusting
for
multiple
confounding
factors,
we
found
that
was
significantly
associated
development
albuminuria
(P
=
0.007)
function
0.002).
However,
there
no
discernible
connection
faiure
0.621).
In
analyses,
association
risk
remained
robust.
findings
highlight
This
easily
calculable
index
can
provide
valuable
information
physicians
predicting
Diabetes Obesity and Metabolism,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 4, 2025
Abstract
Aims
To
explore
the
association
of
remnant
cholesterol
(RC)
and
lipoprotein‐associated
phospholipase
A2
(Lp‐PLA2)
with
composite
adverse
events
in
a
large‐scale
prospective
study.
Methods
All
data
were
collected
from
Asymptomatic
Polyvascular
Abnormalities
Community
study
between
2010
2022.
Serum
levels
Lp‐PLA2
determined
by
enzyme‐linked
immunosorbent
assay.
The
participants
categorized
into
four
groups
based
on
their
RC
levels:
low‐RC/Lp‐PLA2−,
high‐RC/Lp‐PLA2−,
low‐RC/Lp‐PLA2+
high‐RC/Lp‐PLA2+.
endpoint
was
combination
first‐ever
stroke,
myocardial
infarction
or
all‐cause
mortality.
Cox
regression
analyses
performed
to
evaluate
associations
events.
Results
Of
1864
eligible
participants,
average
age
60.6
years,
74.3%
male.
Over
follow‐up
12
we
identified
500
events,
including
210
major
cardiovascular
342
deaths.
When
compared
group
hazard
ratios
95%
confidence
intervals
high‐RC/Lp‐PLA2+
for
infarction,
event,
death
endpoints
1.37
(0.87–2.16),
0.72
(0.28–1.82),
1.29
(0.85–1.95),
1.61
(1.10–2.38)
1.43
(1.07–1.91),
respectively.
A
significant
interaction
status
has
been
found
(
p
<0.05).
In
addition,
joint
modified
sex
<60
versus
≥60
years
interaction:
0.035
0.01,
respectively).
Conclusions
Elevated
associated
an
increased
risk
these
significantly
influenced
age.
Our
highlights
synergistic
effect
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 17, 2025
Remnant
cholesterol
(RC)
has
emerged
as
a
novel
therapeutic
target
beyond
low-destiny-lipoproteins
(LDL-c).
While
elevated
RC
levels
are
strongly
associated
with
cardiovascular
disease
risk
in
the
general
population,
their
specific
role
young-onset
acute
myocardial
infarction
(AMI)
among
patients
type
2
diabetes
mellitus
(T2DM)
remains
insufficiently
explored
and
warrants
further
investigation.
This
retrospective
study
included
AMI
T2DM
admitted
to
First
Affiliated
Hospital
of
Xi'an
Jiaotong
University
from
2018
2022.
Patients
were
stratified
into
tertiles
according
compared
using
thresholds
derived
commanded
values
PREDIMED
cohort
study.
The
primary
outcome
was
AMI.
Group
differences
analyzed
chi-square
test
Kruskal-Wallis
H
test,
while
Spearman
correlation
analyses
assessed
relationships
between
variables.
Univariate
multivariate
logistic
regression
employed
evaluate
association
Among
2,514
participants
(mean
age
61.58
±
11.15
years),
802
(31.9%)
had
increase
increased
significantly
rising
(27.0%
vs
29.7%
39.1%,
P
<
0.001).
showed
significant
positive
total
(TC,
r
=
0.497,
0.001),
triglycerides
(TG,
0.411,
LDL-c
(r
0.166,
independently
higher
(OR:
1.579;
95%
CI:
1.354-1.842;
even
after
adjusting
for
other
traditional
factors
1.415;
CI
1.189-1.684;
Notably,
remained
linked
regardless
whether
within
desired
range.
is
independent
factor
patients,
irrespective
level.
These
findings
underscore
importance
monitoring
managing
clinical
practice
mitigate
this
population.
