Predictive value of the triglyceride-glucose index for short- and long-term all-cause mortality in patients with critical coronary artery disease: a cohort study from the MIMIC-IV database

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: Aug. 22, 2024

Triglyceride-glucose (TyG) index is linked to a poor prognosis for cardiovascular condition and valid indicator of insulin resistance. This study evaluated the potential predicting usefulness TyG all-cause mortality, both short- long-term, those concerning critical coronary artery disease (CAD). In this study, information from 5452 critically-ill individuals with CAD in intensive care units were gathered Medical Information Marketplace Intensive Care (MIMIC-IV) database. Depending on degree, patients categorized into three categories. Clinical outcomes included short-term (30-day) long-term (365-day) mortality. The corresponding relationships involving clinical examined by deploying restricted cubic spline (RCS) regression analysis Cox proportional risk regression. An increased was associated 30-day (Tertile 1: 6.1%, Tertile 2: 7.3%, 3: 9.2%, P = 0.001) 365-day 15.2%, 17.0%, 19.6%, 0.002) death rates across all causes. multiple variables indicates that higher indices all-caused mortality hazard ratios throughout short long terms, larger predictive value former. RCS analyses suggested notably linearly index. reliable predictor at different stages critically ill patients, ability Early intervention elevated may improve their survival outcomes. Future research should delve understanding its pathophysiological mechanisms develop strategies based index, providing new insights enhance outlook patients.

Language: Английский

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The association between the triglyceride‒glucose index and short-term mortality in ICU patients with sepsis-associated acute kidney injury

BMC Infectious Diseases, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 24, 2025

The triglyceride-glucose (TyG) index has emerged as a novel marker for insulin resistance and is commonly observed in patients suffering from sepsis-associated acute kidney injury (SA-AKI). This study explored the correlation between TyG short-term all-cause mortality among SA-AKI patients. We performed retrospective analysis of ICU with using data MIMIC-IV database. primary outcomes were 28-day 90-day mortality. Multivariate Cox proportional hazards regression, restricted cubic spline (RCS) models, Kaplan‒Meier (K‒M) survival analyses used to examine associations Subgroup sensitivity conducted ensure robustness findings. included 4971 patients, 2873 males (57.8%), an average age 65.4 years (± 15.8), 9.10 0.70). RCS revealed U-shaped relationship When was below 9.04, risk at both 28 days 90 reduced (adjusted HRs 0.695, 95% CI: 0.542–0.890 0.691, 0.557–0.858, respectively). In contrast, values above 9.04 associated increased mortality, though not statistically significant 1.026, 0.855–1.231 1.012, 0.863–1.188, K‒M higher rates either high (T3) or low (T1) indices than those moderate (T2) indices. Sensitivity confirmed these even after excluding diabetes, cerebrovascular diseases, stays less 2 days. significantly nonlinearly patients; however, establishing causal two requires validation through larger prospective studies.

Language: Английский

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Glycemic variability and its association with short and long term clinical outcomes in critically ill patients with cerebral hemorrhage

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 6, 2025

Cerebral hemorrhage is a major cause of mortality and disability. This study investigates the association between glycemic variability (GV) short- long-term clinical outcomes such as poor at discharge, 90 days 1 year intensive care unit (ICU) /hospital length stay (LOS) in ICU patients with critically ill cerebral hemorrhage. retrospective analysis examined 732 non-traumatic from Medical Information Mart for Intensive Care (MIMIC)-IV database. GV was quantified ratio standard deviation to mean glucose during stay. To assess associations (poor 90-day 1-year mortality, ICU/hospital LOS), employed logistic regression, Cox proportional hazards models, linear regression. Additionally, non-linear relationships were explored through restricted cubic spline analysis. The investigation further incorporated subgroup sensitivity analyses ensure robustness findings. evaluate incremental predictive value GV, utilized receiver operating characteristic (ROC) curve analysis, net reclassification improvement, integrated discrimination thereby providing comprehensive assessment GV's utility. Higher significantly associated increased risk discharge both patient groups. showed but mortality. thresholds ≥ 0.11 risks. Cohort LOS. impact stronger non-hypertensive male patients. Adding existing severity scores improved their ability adverse outcomes. In admitted ICU, demonstrates an independent over short-term time horizons. Furthermore, extended durations overall hospital stays this population. These findings underscore importance control population suggest that could be valuable prognostic indicator potential therapeutic target.

Language: Английский

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Associations of the triglyceride-glucose index with mortality mediated by blood urea nitrogen among critically ill patients: a cohort study

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 1, 2025

Previous studies have shown that an elevated triglyceride-glucose (TyG) index is associated with all-cause mortality in patients. However, the potential mediating effect of blood urea nitrogen (BUN) within these associations has not been reported. The focus this study was to investigate BUN associations. This a retrospective cohort patients eICU Collaborative Research Database (eICU-CRD) from 208 different ICUs United States between 2014 and 2015 explored. primary endpoint 28 days ICU admission. In addition, following formula used calculate TyG index: Ln [fasting TG (mg/dL) × FBG (mg/dL)/2]. Cox regression model subgroup analysis were performed assess 28-day mortality. assessed mechanism using mediation package R 4.2.0. Of 14,414 mean age 64.1 years, 809 (5.61%) died proportion women 57.9% 8.97 ± 0.82. multivariable-adjusted model, high tertile showed even stronger association than low tertile, hazard ratio (HR) 1.27 (95% CI: 1.05, 1.53; P = 0.014). Mediation mediated 12.4% Our increased risk critically ill appeared be partially by BUN.

Language: Английский

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Triglyceride–glucose index is a significant predictor of hospital mortality in non-diabetic critically ill patients with ischemic stroke: a retrospective cohort study of the MIMIC-IV database

Acta Diabetologica, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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The relationship and differences in the triglyceride-glucose index and all-cause mortality in patients with coronary heart disease combined with cerebrovascular and other comorbidities: an analysis of the MIMIC-IV database

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12

Published: April 9, 2025

This study aims to investigate the predictive capability of triglyceride-glucose index (TyG index) for all-cause mortality among patients with coronary heart disease (CHD), particularly in those cerebrovascular (CVD) and other comorbidities, based on MIMIC-IV database. Using ICD-9/10 coding standards, eligible CHD were identified from database (version 3.0) defined inclusion exclusion criteria ensure sample representativeness. Patients categorized into CVD comorbidity groups. Data rates at 90 days, 1 year, overall collected, along TyG relevant covariates associated survival risk. Baseline analyses, Spearman correlation, restricted cubic splines (RCS) employed assess nonlinear relationship between mortality. Kaplan-Meier curves Cox proportional hazards models utilized evaluate A total 1,872 included, 578 having a rate 50.17%; 1,294 had comorbidities 64.91%. RCS analysis indicated For concurrent CVD, lowest risk occurred 9.37 mmol/L, while was observed 9.36 mmol/L. regression revealed significant association all (HR = 1.15, 95%CI: 1.04-1.28, P < 0.01). In an increase significantly correlated elevated 1.21, 1.02-1.34, The exhibits patients, levels increasing comorbidities. These findings suggest that may serve as critical metabolic marker prognostic evaluation warranting further clinical attention.

Language: Английский

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Effect of Insulin Resistance on Prognosis of Intravenous Thrombolysis in Acute Ischemic Stroke Patients with or Without Type 2 Diabetes Mellitus

Diabetes Metabolic Syndrome and Obesity, Journal Year: 2025, Volume and Issue: Volume 18, P. 1299 - 1309

Published: April 1, 2025

This study aims to investigate the significance of insulin resistance (IR) markers in predicting 48-hour hemorrhagic transformation and 3-month poor prognosis acute ischemic stroke (AIS) patients intravenous thrombolysis (IVT), with or without type 2 diabetes mellitus (T2DM). A total 1352 AIS treated IVT between January 2019 December 2023 were retrospectively reviewed. We analyzed prognostic value IR markers, including triglyceride-glucose (TyG) index, triglyceride body mass index (TYG-BMI), metabolic score (METS-IR), who received T2DM. The primary outcome was (modified Rankin Scale [mRS] ≥ 3). Among 1181 enrolled patients, 328 diagnosed T2DM, representing 27.8% cohort. T2DM group showed a higher proportion (23% vs.11%, p < 0.001), but no significant difference two groups. TyG TyG-BMI, METS-IR all demonstrated predictive for prognosis, showing highest accuracy [area under curve (AUC): 0.848]. optimal cutoff point 7.409, sensitivity 0.762 specificity 0.855 (p 0.001). However, three indexes limited their ability predict transformation. Elevated is an independent risk factor value. These findings provide new understanding that can be used as therapeutic target IVT.

Language: Английский

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Association of albumin-corrected anion gap with severe consciousness disorders and outcomes in ischemic stroke: a retrospective MIMIC analysis

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 29, 2024

The relationship between albumin-corrected anion gap (ACAG) and severe disorder of consciousness (SDOC), in-hospital mortality, long-term mortality in patients with ischemic stroke (IS) remains unclear. This study investigates the association ACAG SDOC other outcomes IS using data from MIMIC-IV database. A total 2,379 were included, a demographic breakdown showing 51% male an incidence 16.4%. Analysis through Cox proportional hazards models indicated that is significantly associated risks both mortality. Additionally, restricted cubic spline(RCS) analysis suggested nearly linear increasing levels SDOC. Kaplan-Meier curves demonstrated significant differences rates SDOC, across varying levels. findings suggest serves as independent predictor for patients. Nonetheless, further prospective studies are needed to confirm these causal relationships.

Language: Английский

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Association between the triglyceride–glucose index and mortality in critically ill patients: A meta-analysis

Medicine, Journal Year: 2024, Volume and Issue: 103(33), P. e39262 - e39262

Published: Aug. 16, 2024

Background: To further identify the association of triglyceride–glucose (TyG) index with risk mortality among critically ill patients admitted to intensive care unit (ICU). Methods: The PubMed, Web Science, and EMBASE databases were searched for relevant studies up February 2, 2024. primary outcomes in-hospital ICU mortality. secondary 30-day mortality, 90-day 1-year hazard ratios (HRs) 95% confidence intervals (CIs) combined evaluate associations between TyG above endpoints. All statistical analyses performed STATA 15.0 software. Results: Ten involving 22,694 included. pooled results demonstrated that an elevated indicated increased (HR = 1.76, CI: 1.41–2.18, P < .001), 1.52, 1.33–1.74, 1.50, 1.02–2.19, .037), 1.42, 1.01–2.00, .043), 1.19, 1.11–1.28, .001). Subgroup analysis based on sex, age, body mass hypertension showed similar results. However, subgroup stratified by diabetes mellitus (DM) revealed 2.21, 1.30–3.78, .004) 1.93, 0.95–3.94, .070) observed only without DM. Conclusion: was significantly associated DM, predicted

Language: Английский

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Triglyceride-glucose index—A novel metabolism disorder biomarker as a promising indicator for predicting postoperative 30-day infections in elderly patients undergoing gastrointestinal-related abdominal and pelvic surgery

Surgery, Journal Year: 2024, Volume and Issue: 176(5), P. 1433 - 1441

Published: Aug. 29, 2024

The triglyceride-glucose index, a reliable surrogate biomarker of insulin resistance, has been reported to be associated with cardiovascular events and atherosclerosis. However, few studies have investigated the association index postoperative infections. This study aimed clinical risk values preoperative in infection complications elderly patients undergoing gastrointestinal-related abdominal pelvic surgery.

Language: Английский

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