The association of serum albumin with 28 day mortality in critically ill patients undergoing dialysis: a secondary analysis based on the eICU collaborative research database DOI Creative Commons
Li Zhang,

Ting Deng,

G. Zeng

et al.

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: Nov. 5, 2024

The relationship between serum albumin and prognosis in critically ill patients has been studied, however, there is a paucity of exploration into non-linear relationships, particularly undergoing dialysis. This study intends to investigate the association (ALB) 28 day mortality We conducted multi-center retrospective cohort dialysis by utilising data from eICU Collaborative Research Database 208 distinct ICUs across United States 2014 2015. focused on within days ICU admission. employed univariate analysis, multi-factor logistic regression, subgroup curve-fitting, threshold effect analysis examine correlation ALB levels mortality. Among 2,315 with median age 63 years, 205 (8.86%) died When level was < 2.7 g/dL, decreased an adjusted odds ratio (OR) 0.34 (95% CI 0.22–0.51, P 0.0001) for every 1 increment ALB. However, no significant changes were observed when at or above this threshold. Our identifies nonlinear dose–response dialysis, specific turning point observed. finding underscores negative risk, lower being associated higher risk particular population.

Language: Английский

Association of the triglyceride glucose index with sudden cardiac death in the patients with diabetic foot ulcer DOI
Yi Chen, Junyan Zhao, Yuchen Sun

et al.

Diabetes Research and Clinical Practice, Journal Year: 2025, Volume and Issue: unknown, P. 112143 - 112143

Published: March 1, 2025

Language: Английский

Citations

0
Serum transactive response DNA binding protein 43 associates with poor short-term neurologic outcome after return of spontaneous circulation following cardiac arrest DOI

Zhangping Sun,

Dongping Yu,

Peijuan Li

et al.

Shock, Journal Year: 2024, Volume and Issue: 62(3), P. 310 - 318

Published: May 23, 2024

ABSTRACT Objective : To explore the association of serum transactive response DNA binding protein 43 (TDP-43) with 28-day poor neurologic outcome in patients return spontaneous circulation (ROSC) after cardiac arrest. Methods We performed a study between January and December 2023. Eligible ROSC following arrest were enrolled. Their baseline characteristics collected, levels TDP-43, tumor necrosis factor-α, interleukin-6 10, C-reactive protein, neuron-specific enolase (NSE) at 24 h measured. The function was assessed by cerebral performance category scores on day 28 ROSC. Results A total 92 included, 51 41 good groups, respectively. Serum TDP-43 significantly higher than group ( P < 0.05). Univariate multivariate logistic regression analyses showed that Witnessed CA, IL-6, NSE associated (all Restricted cubic spline analysis revealed level 11.64 pg/mL might be an ideal cutoff value for distinguishing outcomes. Area under curve (AUC = 0.78) close to 0.82). dynamic nomogram prediction model combined constructed validated. Conclusion Elevated could used together predict

Language: Английский

Citations

1
Association between the triglyceride–glucose index and mortality in critically ill patients: A meta-analysis DOI Creative Commons

Mengzhen Nie,

Biantong Jiang,

Yu Xu

et al.

Medicine, Journal Year: 2024, Volume and Issue: 103(33), P. e39262 - e39262

Published: Aug. 16, 2024

Background: To further identify the association of triglyceride–glucose (TyG) index with risk mortality among critically ill patients admitted to intensive care unit (ICU). Methods: The PubMed, Web Science, and EMBASE databases were searched for relevant studies up February 2, 2024. primary outcomes in-hospital ICU mortality. secondary 30-day mortality, 90-day 1-year hazard ratios (HRs) 95% confidence intervals (CIs) combined evaluate associations between TyG above endpoints. All statistical analyses performed STATA 15.0 software. Results: Ten involving 22,694 included. pooled results demonstrated that an elevated indicated increased (HR = 1.76, CI: 1.41–2.18, P < .001), 1.52, 1.33–1.74, 1.50, 1.02–2.19, .037), 1.42, 1.01–2.00, .043), 1.19, 1.11–1.28, .001). Subgroup analysis based on sex, age, body mass hypertension showed similar results. However, subgroup stratified by diabetes mellitus (DM) revealed 2.21, 1.30–3.78, .004) 1.93, 0.95–3.94, .070) observed only without DM. Conclusion: was significantly associated DM, predicted

Language: Английский

Citations

1
Value of the triglyceride–glucose index and related parameters in heart failure patients DOI Creative Commons

Yunteng Fang,

Jiayi Shen,

Lingchun Lyu

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: July 18, 2024

The triglyceride–glucose (TyG) index, proven to be a crucial insulin resistance biomarker (better than the Homeostasis Model Assessment for Insulin Resistance), is simple and non-invasive. Recently, indisputable evidence has shown that TyG index strongly associated with cardiovascular disease [CVD, including atherosclerosis, heart failure (HF), hypertension] prognosis mortality. Nevertheless, value of in HF patients treated sodium–glucose cotransporter 2 inhibitors (SGLT2is) not been systematically evaluated. Therefore, this review, we summarized its related parameters as markers CVD, especially HF. Furthermore, addressed use SGLT2is GLP-1 receptor antagonists patients. Finally, mechanism “obesity paradox.”

Language: Английский

Citations

0
Association between the triglyceride-glucose index and all-cause mortality in critically ill patients with traumatic brain injury: analysis of two large cohorts DOI Creative Commons
Yunfei Li,

Yu Deng,

Guoyi Gao

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 28, 2024

Abstract Background This study aimed to assess the role of triglyceride-glucose (TyG) index in predicting all-cause mortality critically ill patients with traumatic brain injury (TBI). Methods was a retrospective observational cohort study, and data were obtained from Medical Information Mart for Intensive Care-IV (MIMIC-IV) eICU Collaborative Research Database (eICU-CRD). The participants divided into three groups according TyG tertiles. primary outcome hospital mortality. Multivariate logistic proportional regression analysis restricted cubic spline used evaluate association between TBI. Results A total 865 TBI enrolled. rate intensive care unit (ICU) rates 13.4% 8.4%, respectively. showed that independently associated an elevated risk [OR 1.69 (95% CI 1.23–2.31); P = 0.001] ICU 1.71 1.18–2.48); 0.004]. model revealed risks increased linearly increasing index. Conclusion is significantly finding illustrates may serve as valuable tool identifying who are at

Language: Английский

Citations

0
The association of serum albumin with 28 day mortality in critically ill patients undergoing dialysis: a secondary analysis based on the eICU collaborative research database DOI Creative Commons
Li Zhang,

Ting Deng,

G. Zeng

et al.

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: Nov. 5, 2024

The relationship between serum albumin and prognosis in critically ill patients has been studied, however, there is a paucity of exploration into non-linear relationships, particularly undergoing dialysis. This study intends to investigate the association (ALB) 28 day mortality We conducted multi-center retrospective cohort dialysis by utilising data from eICU Collaborative Research Database 208 distinct ICUs across United States 2014 2015. focused on within days ICU admission. employed univariate analysis, multi-factor logistic regression, subgroup curve-fitting, threshold effect analysis examine correlation ALB levels mortality. Among 2,315 with median age 63 years, 205 (8.86%) died When level was < 2.7 g/dL, decreased an adjusted odds ratio (OR) 0.34 (95% CI 0.22–0.51, P 0.0001) for every 1 increment ALB. However, no significant changes were observed when at or above this threshold. Our identifies nonlinear dose–response dialysis, specific turning point observed. finding underscores negative risk, lower being associated higher risk particular population.

Language: Английский

Citations

0