Disruption of BCAA degradation is a critical characteristic of diabetic cardiomyopathy revealed by integrated transcriptome and metabolome analysis DOI Creative Commons
Yanxia Wu, Wanxiang Jiang, Junlong Wang

et al.

Open Life Sciences, Journal Year: 2024, Volume and Issue: 19(1)

Published: Jan. 1, 2024

In this study, we integrated transcriptomic and metabolomic analyses to achieve a comprehensive understanding of the underlying mechanisms diabetic cardiomyopathy (DCM) in rat model. Functional molecular characterizations revealed significant cardiac injury, dysfunction, ventricular remodeling DCM. A thorough analysis global changes genes metabolites showed that amino acid metabolism, especially breakdown branched-chain acids (BCAAs) such as valine, leucine, isoleucine, is highly dysregulated. Furthermore, study identified transcription factor Gata3 predicted negative regulator gene encoding key enzyme for BCAA degradation. These findings suggest disruption degradation critical characteristic myocardial damage indicate potential role dysregulation metabolism context

Language: Английский

Stem cell-based therapy in cardiac repair after myocardial infarction: Promise, challenges, and future directions DOI Open Access
Wenjun Yan, Yunlong Xia, Huishou Zhao

et al.

Journal of Molecular and Cellular Cardiology, Journal Year: 2024, Volume and Issue: 188, P. 1 - 14

Published: Jan. 20, 2024

Language: Английский

Citations

28
Effect of consumption of anthocyanin-rich products on NMR lipoprotein subclasses and biomarkers in hypercholesterolemic subjects: a randomized controlled trial (the AppleCOR study) DOI Creative Commons
Sara Fernández‐Castillejo, Elisabet Llauradó, Lorena Calderón-Pérez

et al.

Food & Function, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Anthocyanin-rich products (RFA and AI) decreased LDLc; ApoB; total, large, small LDL-P; LDL size; TG/HDL ratio, large TRL, GlycA alanine versus WFA. Thus, anthocyanin-rich provided greater protection against CVD risk than

Language: Английский

Citations

0
Blood metabolites mediate causal inference studies on the effect of gut microbiota on the risk of vascular calcification DOI Creative Commons
Aoran Huang,

Jianshuai Ma,

Huijin Zhu

et al.

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Metabolomics study of dietary Pleurotus eryngii β-type glycosidic polysaccharide on colitis induced by dextran sodium sulfate in mice – Exploration for the potential metabolic indicators in urine and serum DOI
Gaoxing Ma, Qi Tao, Xinyi Li

et al.

Food Chemistry, Journal Year: 2024, Volume and Issue: 458, P. 140195 - 140195

Published: June 24, 2024

Language: Английский

Citations

2
Genetic and Lifestyle-Related Factors Influencing Serum Hyper-Propionylcarnitine Concentrations and Their Association with Metabolic Syndrome and Cardiovascular Disease Risk DOI Open Access

Yong‐Hwa Lee,

Sunmin Park

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(21), P. 15810 - 15810

Published: Oct. 31, 2023

The genetic and environmental determinants of serum propionylcarnitine concentrations (PC) remain largely unexplored. This study investigated the impact factors on levels in middle-aged elderly participants from Ansan/Ansung cohort Korean Genome Epidemiology Study. Our goal was to understand role PC risk metabolic syndrome (MetS) leading cardiovascular disease, particularly concerning branched-chain amino acid (BCAA) metabolism. We analyzed participants’ demographic, lifestyle, biochemical data with without MetS. Serum metabolite concentrations, including carnitine, acylcarnitine, were measured, components MetS evaluated. Genetic variants associated low high selected using genome-wide association studies after adjusting for MetS-related parameters. Further, lifestyle that interacted polygenic score (PRS) analyzed. Participants older less educated, their alcohol intake higher than non-MetS participants. significantly increased BCAAs other acids. Higher positively correlated components, insulin resistance, factors. Intake calcium, sodium, vitamin D inversely PC, but coffee consumption linked PC. Multiple C2 And Transmembrane Domain Containing-1 (MCTP1)_rs4290997, Kinesin Family Member-7 (KIF7)_rs2350480, Coagulation Factor-II (F2)_rs2070850, Peroxisomal Biogenesis Factor-3 (PEX3)_rs223231, TBC1 Member-22A (TBC1D22A)_rs910543, Phospholipase A2 Group-IV-C (PLA2G4C)_rs7252136 interact each have a threefold influence PRS six-genetic variant model also age; diet rich beans, potato, kimchi; smoking status, influencing In conclusion, elevated disease risk, suggesting potential as biomarkers.

Language: Английский

Citations

2
Type 2 Diabetes, Circulating Metabolites, and Calcific Aortic Valve Stenosis: A Mendelian Randomization Study DOI Creative Commons
Rui Shen, Chengliang Pan,

Guiwen Yi

et al.

Metabolites, Journal Year: 2024, Volume and Issue: 14(7), P. 385 - 385

Published: July 13, 2024

Epidemiological studies have shown an association between type 2 diabetes (T2D) and calcific aortic valve stenosis (CAVS), but the potential causal relationship underlying mechanisms remain unclear. Therefore, we conducted a two-sample two-step Mendelian randomization (MR) analysis to evaluate of T2D with CAVS mediating effects circulating metabolites blood pressure using genome-wide study (GWAS) summary statistics. The inverse variance weighted (IVW) method was used for primary MR analysis, comprehensive sensitivity analyses were performed validate robustness results. Our results showed that genetically predicted associated increased risk (OR 1.153, 95% CI 1.096-1.214,

Language: Английский

Citations

0
Circulating glutamine/glutamate ratio is closely associated with type 2 diabetes and its associated complications DOI Creative Commons
Fei Han, Chaofei Xu,

Xinxin Hangfu

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: July 18, 2024

Objective This study aims to conduct a comprehensive investigation of the serum amino acid profiles individuals with type 2 diabetes (T2D) and its related complications. Methods Patients T2D were enrolled in this study. Sixteen kinds common acids fasting circulating assessed through liquid chromatography-mass spectrometry (LC-MS). Subsequently, correlation, regression analyses, receiver operating characteristic (ROC) curves conducted assess associations between clinical indicators. Results Thirteen different identified diabetic patients, as compared normal controls. The Glutamine/Glutamate (Gln/Glu) ratio was negatively correlated BMI, HbA1c, uric acid, triglyceride-glucose (TyG) index, while it positively HDL-C. Logistic analyses indicated that Gln/Glu consistent protective factor for both (OR = 0.65, 95% CI 0.50-0.86) obesity 0.79, 0.66-0.96). ROC demonstrated Gln/Glu, proline, valine, leucine provided effective predictions risk, exhibiting highest AUC [0.767 (0.678-0.856)]. In patients T2D, Gln only displayed negative correlation HbA1c ( r -0.228, p 0.017). Furthermore, HOMA-β exhibited Glu -0.301, 0.003) but positive 0.245, Notably, logistic revealed an inverse risk kidney disease 0.74, 0.55-0.98) association retinopathy 1.53, 1.08-2.15). Conclusion significant diabetes, metabolic parameters, These findings shed light on pivotal role metabolism associated

Language: Английский

Citations

0
Global, Regional, and National Burden of Atherosclerotic Cardiovascular Disease Attributed to Metabolic Risks from 1990 to 2021: A Systematic Analysis of Global Burden of Disease Data and Temporal Trends DOI

Shihan Xu,

Yanfei Liu, Qing Wang

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0
Gut microbiota, physical activity and/or metabolic markers in healthy individuals - towards new biomarkers of health DOI Creative Commons
Mari C. W. Myhrstad,

Emilia Ruud,

Line Gaundal

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 28, 2024

The global prevalence of the metabolic disease Type 2 Diabetes (T2D) is increasing. Risk factors contributing to development T2D include overweight and obesity, lack physical activity (PA), an unhealthy diet. In addition, gut microbiota has been shown affect regulation. Since preventable, efforts should be put into discovery new biomarkers for early detection individuals at risk developing disease.

Language: Английский

Citations

0
Disruption of BCAA degradation is a critical characteristic of diabetic cardiomyopathy revealed by integrated transcriptome and metabolome analysis DOI Creative Commons
Yanxia Wu, Wanxiang Jiang, Junlong Wang

et al.

Open Life Sciences, Journal Year: 2024, Volume and Issue: 19(1)

Published: Jan. 1, 2024

In this study, we integrated transcriptomic and metabolomic analyses to achieve a comprehensive understanding of the underlying mechanisms diabetic cardiomyopathy (DCM) in rat model. Functional molecular characterizations revealed significant cardiac injury, dysfunction, ventricular remodeling DCM. A thorough analysis global changes genes metabolites showed that amino acid metabolism, especially breakdown branched-chain acids (BCAAs) such as valine, leucine, isoleucine, is highly dysregulated. Furthermore, study identified transcription factor Gata3 predicted negative regulator gene encoding key enzyme for BCAA degradation. These findings suggest disruption degradation critical characteristic myocardial damage indicate potential role dysregulation metabolism context

Language: Английский

Citations

0