European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177389 - 177389
Published: Feb. 1, 2025
Language: Английский
Hypertension, Journal Year: 2024, Volume and Issue: 81(7), P. 1637 - 1643
Published: May 16, 2024
Prediabetes has garnered increasing attention due to its association with cardiovascular conditions, especially hypertension, which heightens the risk of prefrailty and frailty among older individuals.
Language: Английский
Citations
36
Journal of Enzyme Inhibition and Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 40(1)
Published: Feb. 6, 2025
Lespedeza bicolour Turcz. is a traditional medicinal plant with wide range of ethnomedicinal values. The main components L. essential oil (EO) were β-pinene (15.41%), β-phellandrene (12.43%), and caryophyllene (7.79%). EO showed antioxidant activity against ABTS radical DPPH an IC50 value 0.69 ± 0.03 mg/mL 10.44 2.09 mg/mL, respectively. FRAP was 81.96 6.17 μmol/g. had activities acetylcholinesterase, α-glucosidase, β-lactamase values 309.30 11.16 μg/mL, 360.47 35.67 27.54 1.21 Molecular docking methyl dehydroabietate docked well all tested enzymes. Sclareol (+)-borneol acetate the strongest binding affinity to α-glucosidase β-lactamase, present study provides direction for searching enzyme inhibitors three enzymes shows possesses potential treat series diseases.
Language: Английский
Citations
3
Diabetology & Metabolic Syndrome, Journal Year: 2025, Volume and Issue: 17(1)
Published: Feb. 21, 2025
Long-term exposure to air pollution significantly increases the risk of cardiovascular disease (CVD); however, association and underlying mechanisms in individuals with diabetes remain unconfirmed. We used data from China Health Retirement Longitudinal Study (CHARLS) follow 5,430 adults over a four-year period. Baseline CVD status were determined, high-resolution assess PM1, PM2.5, PM10, O3. The inflammatory lipid ratio (ILR) was calculated reflect metabolic states. A generalized linear model (GLM) employed analyze effects ILR on diabetes-related risk. prevalence 8.5% healthy population 13.8% diabetic population. Air associated an increased among individuals. For each interquartile range (IQR) increase concentrations pollutants O3, group rose by 21%, 19%, 28%, respectively. Higher values positively incidence (OR = 1.019, 95% CI: 1.001-1.037, P < 0.05), nonlinear relationship observed between levels (PNonlinear 0.0381), indicating that higher exacerbate impact Among middle-aged older diabetes, is CVD, intensifies this process. Therefore, implementing effective public health interventions reduce populations essential.
Language: Английский
Citations
3
Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)
Published: May 3, 2024
Abstract Background Vasculopathy is the most common complication of diabetes. Endothelial cells located in innermost layer blood vessels are constantly affected by flow or vascular components; thus, their mechanosensitivity plays an important role mediating regulation. damage, one main causes hyperglycemic complications, has been extensively studied. However, mechanosensitive signaling endothelial damage remains unclear. Methods Vascular endothelial-specific Piezo1 knockout mice were generated to investigate effects on Streptozotocin-induced hyperglycemia and injury. In vitro activation knockdown was performed evaluate proliferation, migration, tubular function human umbilical vein high glucose. Reactive oxygen species production, mitochondrial membrane potential alternations, oxidative stress-related products used assess extent stress caused activation. Results Our study found that VE CreERT2 ;Piezo1 flox/flox with conditional cells, deficiency alleviated streptozotocin-induced reduced apoptosis abscission thoracic aortic decreased inflammatory response tissue Moreover, showed a thinner wall, tunica media increased nitric oxide synthase expression transgenic mice, indicating relief hyperglycemia. We also aggravated injury resulted severe dysfunction through Ca 2+ -induced CaMKII-Nrf2 axis cells. partially restored superoxide dismutase activity malondialdehyde content aorta. Mechanistically, CaMKII phosphorylation Nrf2 its downstream molecules HO-1 NQO1. Conclusion summary, our revealed involved glucose-induced dysfunction, which have great significance for alleviating
Language: Английский
Citations
9
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Jan. 29, 2025
Oxidative balance score (OBS) is a composite measures that assess the between pro-oxidant and antioxidant factors in an individual's diet lifestyle, with higher scores indicating greater exposure. Despite its potential significance, there limited body of research exploring relationship OBS all-cause cardiovascular disease (CVD) mortality specifically younger patients diabetes. We aimed to investigate possible CVD Data for this study were obtained from 2003–2018 NHANES. This enrolled 3501 participants. The endpoints mortality, determined by National Death Index (NDI). OBS, which consists 16 dietary 4 lifestyle factors, categorized into pro-oxidants antioxidants. was four quartiles (Q1-Q4). used multivariable Cox proportional hazards regression models examine association continuous quartile (lifestyle antioxidants such as physical activity, etc., alcohol, smoking, etc.), (dietary fiber, β-carotene, riboflavin, pro-oxidants, total fat, etc.) mortality. Additionally, we explored restricted cubic spline (RCS) analysis also performed subgroup analyses interaction tests. occurrence 409 deaths (11.7%) 108 CVD-related (3.1%) recorded during follow-up period. Our results found negatively associated patients' RCS further validated linear negative correlation our revealed may be influenced alcohol use. In conclusion, nationally representative American diabetes suggest Antioxidant-rich diets improvements are essential reducing patients.
Language: Английский
Citations
1
Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141868 - 141868
Published: Feb. 1, 2025
Language: Английский
Citations
1
GeroScience, Journal Year: 2025, Volume and Issue: unknown
Published: March 21, 2025
Abstract Vascular cognitive impairment (VCI) is a leading cause of age-related decline, driven by cerebrovascular dysfunction and cerebral small vessel disease (CSVD). Emerging evidence suggests that cerebromicrovascular endothelial senescence plays an important role in the pathogenesis VCI promoting blood flow dysregulation, neurovascular uncoupling, blood–brain barrier (BBB) disruption, development microhemorrhages (CMHs). This review explores concept as continuum vascular aging, linking macrovascular atherosclerosis with microvascular dysfunction. It examines mechanisms which drives pathology highlights impact cardiovascular risk factors accelerating these processes. We examine preclinical clinical studies provide compelling atherosclerosis-induced exacerbates impairment. In particular, findings suggest targeting senescent cells through senolytic therapy can restore function improve outcomes experimental models atherosclerosis. Given growing recognition therapeutic target, further research warranted to explore novel interventions such senolytics, anti-inflammatory agents, metabolic modulators. The circulating biomarkers (e.g., senescence-associated secretory phenotype [SASP] components endothelial-derived extracellular vesicles) could enable early detection stratification individuals at high for VCI. Additionally, lifestyle modifications, including Mediterranean diet, hold promise delaying mitigating decline. conclusion, key mechanistic link between Addressing aging modifiable factor targeted offers promising strategy reducing burden preserving populations.
Language: Английский
Citations
1
Biomolecules, Journal Year: 2024, Volume and Issue: 14(6), P. 689 - 689
Published: June 13, 2024
Reactive oxygen species (ROSs) are byproducts of normal cellular metabolism and play pivotal roles in various physiological processes. Disruptions the balance between ROS levels body’s antioxidant defenses can lead to development numerous diseases. Glutathione peroxidase 3 (GPX3), a key component system, is an oxidoreductase enzyme. GPX3 mitigates oxidative damage by catalyzing conversion hydrogen peroxide into water. Beyond its function, vital regulating metabolism, modulating cell growth, inducing apoptosis facilitating signal transduction. It also serves as significant tumor suppressor cancers. Recent studies have revealed aberrant expression several non-neoplastic diseases, associating it with multiple pathological This review synthesizes current understanding regulation, highlighting extensive noncancerous Additionally, this paper evaluates potential diagnostic biomarker explores emerging therapeutic strategies targeting enzyme, offering avenues for future clinical treatment conditions.
Language: Английский
Citations
8
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11641 - 11641
Published: Oct. 30, 2024
Gestational diabetes (GD) is a metabolic disorder characterized by glucose intolerance during pregnancy, significantly impacting maternal and fetal health. Its global prevalence approximately 14%, with risk factors including obesity, family history of diabetes, advanced age, ethnicity, which are linked to cellular molecular disruptions in regulation insulin resistance. GD associated short- long-term complications for both the mother newborn. For mothers, increases developing type 2 cardiovascular diseases, syndrome. In offspring, exposure utero predisposes them intolerance, disorders later life. This review aims elucidate complex mechanisms underlying inform development effective therapeutic strategies. A systematic was conducted using medical subject headings (MeSH) terms related GD's pathophysiology. Inclusion criteria encompassed original studies, reviews, meta-analyses focusing on impact health, adhering PRISMA guidelines. Data extraction captured study characteristics, outcomes, key findings, conclusions. disrupts signaling pathways, leading impaired uptake Mitochondrial dysfunction reduces ATP production reactive oxygen species, exacerbating oxidative stress. Hormonal influences, chronic inflammation, dysregulation mammalian target rapamycin (mTOR) pathway further impair signaling. Gut microbiota alterations, gene expression, epigenetic modifications play significant roles GD. Ferroptosis placental primarily contribute intrauterine growth restriction. Conversely, macrosomia arises from hyperglycemia subsequent hyperinsulinemia, resulting excessive growth. The inflammatory state stress exacerbate these complications, creating hostile environment. pathophysiology involves multiple signaling, mitochondrial function, Effective management requires early detection, preventive strategies, international collaboration standardize care improve outcomes mothers babies.
Language: Английский
Citations
7
Journal of Diabetes Investigation, Journal Year: 2024, Volume and Issue: 15(7), P. 805 - 816
Published: Feb. 28, 2024
Abstract Low levels of high‐density lipoprotein‐cholesterol (HDL‐C) is considered a major cardiovascular risk factor. However, recent studies have suggested more U‐shaped association between HDL‐C and disease. It has been shown that the cardioprotective effect HDL related to functions particles rather than their cholesterol content. are highly heterogeneous multiple relevant cardiometabolic conditions including efflux capacity, anti‐oxidative, anti‐inflammatory, vasoactive properties. There quantitative qualitative changes in as well functional abnormalities both type 1 2 diabetes. Non‐enzymatic glycation, carbamylation, oxidative stress, systemic inflammation can modify composition therefore functions, especially situations poor glycemic control. Studies proteomics lipidomics provided further insights into structure–function relationship Interestingly, also pleiotropic anti‐diabetic effect, improving control through improvement insulin sensitivity β‐cell function. Given important role health, HDL‐based therapeutics being developed enhance increase levels. Among these, recombinant small synthetic apolipoprotein A‐I mimetic peptides may hold promise for preventing treating diabetes
Language: Английский
Citations
6