Waist-circumference-to-height-ratio had better longitudinal agreement with DEXA-measured fat mass than BMI in 7237 children

Pediatric Research, Journal Year: 2024, Volume and Issue: 96(5), P. 1369 - 1380

Published: March 5, 2024

Abstract Background The absolute agreement of surrogate measures adiposity with dual-energy X-ray absorptiometry (DEXA)-measured body composition was examined. Methods Over a 15-year follow-up, 7237 (3667 females) nine-year-old children from the Avon Longitudinal Study Parents and Children (ALSPAC) UK birth cohort were included. Total fat mass (FM) trunk FM serially measured DEXA at ages 9, 11, 15, 17, 24 years. BMI waist circumference-to-height ratio (WHtR) computed. Pearson’s correlations, intraclass correlations (ICC), area under curve (AUC) analyses conducted. Results 15 years, BMI, total FM, increased but WHtR relatively stable. provided better longitudinal [males ICC 0.84 (95% CI 0.84–0.85); females 0.81 (0.80–0.82)] than [(males (0.65 (0.64–0.66); 0.72 (0.71–0.73)] as well 9–24 cut-point for predicting excess (75th–95th percentile) 0.50–0.53 in males [AUC 0.86–0.94, sensitivity 0.51–0.79 specificity 0.93–0.95]. 0.52–0.54 0.83–0.95, 0.38–0.68 0.92–0.95]. similar FM. Conclusion is an inexpensive alternative to pediatrics. Impact Waist measure index (BMI) discriminating lean childhood through young adulthood. has been used several decades. However, emerging findings suggest that fails discriminate between mass. This first-ever study over 7000 followed up years identified accurate discriminates could replace obesity

Language: Английский

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Opposite outcomes of triglyceride-glucose index and associated cardiovascular mortality risk in type 2 diabetes mellitus participants by different obesity criteria

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 16, 2025

We investigated the correlation between Triglyceride-glucose (TyG) index and cardiovascular disease (CVD) mortality in type 2 diabetes mellitus (T2DM) population across different obesity classications using a cohort study. analyzed 7867 T2DM participants from National Health Nutrition Examination Survey 1999-2018, categorizing them into obese or non-obese group by body mass (BMI) waist circumference (WC). Cox regression models were used to estimate TyG CVD risk, comparing results two classifications. Over 9.1-year follow-up, 691 deaths occurred. Among (BMI-defined), hazard ration for was 1.73 fourth quartile of compared with first group. Conversely, among (WC-defined), held 1.51-fold risk The association higher observed WC-defined but not BMI-defined obesity. A totally opposite relationship appeared based on how defined BMI WC participants, suggesting reevaluation BMI's accuracy predicting risk.

Language: Английский

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Childhood obesity: The threatening apprentice of the adiposity empire

Reviews in Endocrine and Metabolic Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Abstract Childhood obesity is a global health problem, with its prevalence having tripled since 1975. The increase in has been predominantly developing countries, but also those high economic status. Nowadays, there are multiple definitions, however, one of the most accurate which defines as accumulation excessive body adiposity and not an weight excess. Nevertheless, mass index (BMI) frequently used tool for classification, according to cut-off points established by Center Disease Control World Health Organization tables. In children adolescents excess related appearance cardiovascular disease adulthood many comorbidities such metabolic syndrome, insulin resistance, type 2 diabetes, hypertension dysfunction-associated steatotic liver disease, among others. Currently, still controversy about ideal indicator measuring overweight obesity. BMI standardized measure may miss cases composition pathological despite within normal-weight category. An adequate knowledge impact on dysfunctional well diagnosis will allow professionals address this condition more precise comprehensive manner, substantially improve associated cardiometabolic risk prognosis.

Language: Английский

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Revisiting the beyond BMI paradigm in excess weight diagnosis and management: A call to action

European Journal of Clinical Investigation, Journal Year: 2024, Volume and Issue: 54(7)

Published: April 17, 2024

Abstract Adolphe Quételet, a 19th‐century Belgian sociologist and statistician, pioneered the incorporation of statistics into social sciences. He initiated development anthropometry since he was interested in identifying proportions ‘ideal man’. devised ratio between weight height, originally termed Quételet Index , today widely known used as body mass index or BMI. In 1835, demonstrated that normal curve accommodates distribution human traits articulating his reasoning on variance around average. Quételet's long‐lasting legacy establishment simple measure to classify people's relative an ideal for their height endures with minor variations having dramatically influenced public health agendas. While being very useful, limitations BMI are well known. Thus, revisiting beyond paradigm is necessity era precision medicine morphofunctional assessment representing way forward via composition functionality appraisal. healthcare systems were designed address acute illnesses, today's demands require radical rethinking together original reappraisal our diagnosis treatment approaches from multidimensional perspective. Embracing new methodologies advance field, gain closer look at underlying pathophysiology excess weight, keep spotlight improving diagnostic performance demonstrate its clinical validity. order provide every patient most accurate appropriate management, high degree standardization personalization needed.

Language: Английский

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The evolution of the understanding of obesity over the last 100 years

International Journal of Obesity, Journal Year: 2024, Volume and Issue: 49(2), P. 168 - 176

Published: Nov. 7, 2024

Language: Английский

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L-shaped association between lean body mass to visceral fat mass ratio with hyperuricemia: a cross-sectional study

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: April 20, 2024

Abstract Background Insufficient attention has been given to examining the correlation between body composition and hyperuricemia, leading inconsistent findings. The primary objective of this research is explore association lean mass index (LMI), visceral fat (VFMI), hyperuricemia. A specific emphasis will be placed on assessing link ratio (LMI/VFMI) Methods present study employed a cross-sectional design involved total 9,646 individuals who participated in National Health Nutrition Examination Survey (NHANES). To associations among variables, logistic linear regressions were employed. Additionally, subgroup analyses sensitivity conducted based various characteristics. Results results showed that LMI was positively associated with hyperuricemia (for Per-SD: OR = 1.88, 95%CI: 1.75, 2.01; for quartiles [Q4:Q1]: 5.37, 4.31, 6.69). Meanwhile, VFMI positive 2.02, 2.16; =8.37, 6.70, 10.47). When considering effects In LMI/VFMI, an L-shaped negative observed 0.45, 0.42, 0.49; 0.16, 0.13, 0.20). Subgroup demonstrated robustness across different subgroups. segmented regression analysis indicated saturation effect 5.64 LMI/VFMI (OR 0.20, 0.17, 0.24). For every 2.72-fold increase risk reduced by 80%. Conclusion non-linearly serum uric acid. Whether causal needs confirmed further longitudinal studies or Mendelian randomization.

Language: Английский

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WITHDRAWN: Differential Identification of Childhood Overweight and Obesity Based on Bioimpedance Analysis of Body Composition

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

29 January, 2025. Research Square has withdrawn this preprint due to overlap with another author's published work: [Wiad Lek. 2024;77(3):402-408. doi: 10.36740/WLek202403105](https://wiadlek.pl/wp-content/uploads/archive/2024/WiadLek2024i3.pdf).

Language: Английский

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Sex differences in associations between body composition and cardiometabolic indicators in Chinese children: a cross-sectional study

BMJ Open, Journal Year: 2025, Volume and Issue: 15(5), P. e095049 - e095049

Published: May 1, 2025

Objectives Obesity is a growing global public health problem that increases the risk of cardiovascular disease. The aim present study was to assess effects body composition on cardiometabolic indicators in children. Design Cross-sectional analysis. Setting China, Beijing Children and Adolescents Health Cohort Study between 2022 2023. Participants This cross-sectional included 5555 children adolescents aged 6 17 years from 11 kindergartens schools. Outcome measures We measured using multifrequency bioelectrical impedance analysis assessed indicators, including blood pressure, plasma glucose lipids. Linear regression binary logistic were performed associations abnormalities. Results In boys, fat mass index (FMI) positively correlated with total cholesterol (TC) (in normal fat-free (FFM) group, β=0.036, 95% CI 0.027 0.046; high FFM β=0.034, 0.016 0.051) fasting (FPG) β=0.019, 0.012 0.026; β=0.030, 0.005 0.054). FFMI negatively associated TC only group (β=−0.047, −0.069 −0.034) boys. However, girls, FMI not significantly FPG (β=0.033, 0.024 0.041), β=−0.058, −0.079 −0.038; β=−0.049, −0.084 −0.015). Normal FFM-high (OR=2.065, 1.379 3.091) increased visceral region (OR=1.357, 1.195 1.540) factors for boys but girls. Conclusions Body factors, stored different regions has differential influences indicators. There sex differences relationships findings suggest more strongly than Prevention obesity abnormalities may be important

Language: Английский

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National Survey on the Prevalence and Geospatial Variation of Body Fat Percentage Among Preschoolers — 31 PLADs, China, 2020

Deleted Journal, Journal Year: 2025, Volume and Issue: 7(19), P. 650 - 657

Published: Jan. 1, 2025

Body fat percentage (BF%) is a fundamental indicator of body composition that provides critical insights into distribution patterns. However, comprehensive national data on BF% and its geographical patterns among the Chinese preschoolers aged 3 to 6 years remain limited. This study presents novel analyzing prevalence preschool children, along with key determinants. The findings reveal mean 20.7% preschoolers, distinct clustering analysis identifies significant hotspots cold spots aligned major boundaries, while demonstrating sex, parental characteristics, education level, environmental factors significantly influence children's BF%. These provide baseline levels substantial disparities. observed regional variations suggest need for targeted public health interventions region-specific strategies childhood obesity prevention, emphasizing importance implementing evidence-based intervention programs tailored local contexts.

Language: Английский

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A differentiated approach to the diagnosis of overweight and obesity in children based on bioimpedance analysis of body composition

Wiadomości Lekarskie, Journal Year: 2024, Volume and Issue: 77(3), P. 402 - 408

Published: Jan. 1, 2024

Aim: The current study introduces a novel diagnostic algorithm employing bioimpedance analysis to comprehensively evaluate body composition in children, assessing fat content, skeletal muscle and distribution. Materials Methods: Bioelectrical impedance measurements were obtained using the TANITA MC-780 MA analyzer. Indicators such as weight, BMI, total absolute limb mass, strength, waist-to-hip ratio (WHR) assessed. A sample of 101 children aged 9 14 studied proposed algorithm, refining BMI-based classifications. Results: comprises three steps, categorizing based on presence sarcopenia, central It identified diverse somatotypes within groups classified by BMI. Notably, it revealed prognostically unfavorable somatotypes, sarcopenic obesity with distribution, highlighting potential health risks. Current BMI-centric diagnoses may misclassify cardiometabolic risks, making early detection challenging. enables detailed evaluation, unmasking metabolically conditions like obesity. incorporation functional tests, standardized hand-grip test, enhances accuracy. WHR indicator for characterizing distribution provides practical method determining children. Conclusions: This comprehensive offers an alternative classifications, enabling associated Further validation through large-scale epidemiological studies is essential establish correlations between fostering more nuanced individualized approach pediatric management.

Language: Английский

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