European Journal of Clinical Investigation, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 20, 2024
Both chronic kidney disease (CKD) and type 2 diabetes mellitus (T2DM) confer a high risk of cardiovascular mortality. These entities frequently coincide. The separate joint impact CKD T2DM on the major events (MACE) survival is unclear.
Language: Английский
Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 21, 2025
Chronic kidney disease (CKD) is a serious complication of diabetes, and the global burden gradually increasing. This study systematically analyzed trends future projections worldwide chronic caused by type 1 2 diabetes mellitus based on Global Burden Disease Study (GBD) using data from 1990 to 2021. Number deaths, Age-standardized mortality rates, disability-adjusted life years (DALYs), age-standardized DALYs rate were used estimate burden. The Estimated Annual Percentage Changes (EAPCs) calculate in each subtype different regions assessed impact various age groups metabolic factors due diabetes. ARIMA model was further predict Diabetic nephropathy 2022 2050. results showed that its EAPCs varied significantly distribution across Sociodemographic Index subgroups countries as well among 204 worldwide. In addition, influence also significant variability. effects number deaths positively correlated with age. Different have CKD predicts will continue increase absence interventions. To effectively manage more accurate cost-effective diagnostic tools interventions are needed future, especially low - middle-income poor healthcare resources.
Language: Английский
Citations
1
Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)
Published: March 20, 2025
Abstract Background Familial hypercholesterolemia (FH) is a genetic condition characterized by elevated LDL-C and increased cardiovascular risk. Beyond levels, the impact of genotype on glucose homeostasis has not been well evaluated. We aimed to evaluate glycemic status atherosclerotic injury in FH subjects. Methods conducted cross-sectional study 322 subjects lipid-lowering therapy without history disease. Biochemical analyses as vascular profile assessment were obtained from all The population was divided into two groups according genotype: LDL receptor (LDLR) group non-LDLR (NLDLR) group. Results LDLR exhibited higher prevalence low (LGS) than NLDLR (44.1% vs. 26%, p < 0.01), whereas high (HGS) more prevalent compared with (74% 55.9%, 0.01). peripheral plaques (93.4% 73%, 0.05), while coronary artery calcification (CAC) presence (74.7% 48%, In secondary analysis stratified three based NLDLR, defective, null groups. LGS progressively group, HGS showed an inverse trend ( for 0.05). Peripheral plaque decreased CAC Logistic regression that mutation inversely associated both 0.01) strongest association. Conclusions mutations worse profile, association HGS. integrations genetic, lipid data could be useful better identify metabolic atherosclerosis distribution Graphical abstract Research insights What currently known about this topic? levels. protected pancreatic β-cells cholesterol accumulation. NGS improved diagnosis genes implicated disorder. key research question? (monogenic or mutation/polygenic) status? new? heterogeneous mutation. plasma modulate subclinical atherosclerosis. How might studyinfluence clinical practice? Genetic, lipid, profiles FH.
Language: Английский
Citations
1
Clinical Rheumatology, Journal Year: 2025, Volume and Issue: unknown
Published: March 26, 2025
Language: Английский
Citations
1
Biomolecules, Journal Year: 2024, Volume and Issue: 14(6), P. 687 - 687
Published: June 13, 2024
The increasing utilization of Glucagon-like Peptide-1 receptor agonists (GLP-1 RAs) in managing type 2 diabetes mellitus has raised interest regarding their impact on thyroid function. In fact, while these agents are well known for efficacy glycemic control and weight management, association with disorders requires clarification due to the complex interplay between hormones metabolic pathways. Thyroid dysfunction commonly co-occurs conditions such as obesity, suggesting a profound interconnection systems. This review aims contribute deeper understanding interaction GLP-1 RAs clarify safety diabetic patients disorders. By synthesizing existing evidence, this highlights that, despite various studies exploring topic, current evidence is inconclusive, conflicting results. It important note that drugs relatively recent, longer-term larger sample sizes likely needed draw clearer conclusions. Currently, no guidelines provide definitive directions clinical issue; however, it advisable include function tests routine screening patients, particularly those treated Ras, goal optimizing patient care management.
Language: Английский
Citations
8
Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)
Published: July 5, 2024
Abstract Background Accompanied by activation of the NOD-like receptor protein 3 (NLRP3) inflammasome, aberrant connexin 43 (Cx43) hemichannel-mediated ATP release is situated upstream inflammasome assembly and inflammation contributes to multiple secondary complications diabetes associated cardiometabolic comorbidities. Evidence suggests there may be a link between Cx43 hemichannel activity in diabetic kidney. The consequences blocking tubular priming/activation NLRP3 model kidney disease (DKD) was investigated. We examined downstream markers proinflammatory chemoattractant role secretome on macrophage recruitment activation. Methods Analysis human transcriptomic data from Nephroseq repository correlated gene expression renal function DKD. Primary proximal tubule epithelial cells (RPTECs) monocyte-derived macrophages (MDMs) were cultured high glucose inflammatory cytokines as DKD assess activity, epithelial-to-macrophage paracrine-mediated crosstalk. Tonabersat assessed for hemichannels. Results Transcriptomic analysis biopsies patients with showed that increased declining glomerular filtration rate (GFR) proteinuria. In vitro, blocked glucose/cytokine-dependant increases reduced RPTECs. observed reciprocal relationship which exacerbated release, events driven nuclear factor kappa-B (NFκB)-mediated priming opening, changes Tonabersat. Conditioned media (CM) RPTECs treated glucose/cytokines MDMs, an effect when pre-treated Co-culture using conditioned Tonabersat-treated dampened marker migration. Conclusion Using DKD, we report first time trigger instigate NLRP3-induced Recapitulating observations previously reported retinopathy, these suggest blockers (i.e., Tonabersat) dampen multi-system damage diabetes.
Language: Английский
Citations
4
European Journal of Internal Medicine, Journal Year: 2024, Volume and Issue: 132, P. 118 - 126
Published: Dec. 13, 2024
Language: Английский
Citations
4
Renal Failure, Journal Year: 2025, Volume and Issue: 47(1)
Published: Feb. 23, 2025
Objectives Diabetic kidney disease (DKD) is driven by mitochondrial dysfunction and immune dysregulation, yet the mechanistic interplay remains poorly defined. This study aimed to identify key molecular networks linking pathways DKD progression, with a focus on uncovering biomarkers therapeutic targets.
Language: Английский
Citations
0
Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16
Published: March 18, 2025
Numerous studies have shown that dyslipidemia increases the risk of atherosclerotic cardiovascular disease (ASCVD) and significantly impacts occurrence progression diabetic kidney (DKD). Early interventions for lipid metabolism disorders in DKD may improve renal function. This article reviews clinical characteristics dyslipidemia, mechanisms lipid-induced injury, advances lipid-lowering therapy DKD. We searched PubMed, Web Science, EMBASE to identify relevant articles, using keywords such as "diabetic disease", nephropathy", "diabetes", "dyslipidemia", "kidney", "cardiovascular "lipid therapy". High triglyceride (TG) low high-density lipoprotein (HDL) are associated with increased risks albuminuria estimated glomerular filtration rate (eGFR) decline. Abnormal damage podocytes tubular epithelial cells via ectopic deposition, eventually impairing function increasing urinary albumin excretion. Lipid-lowering therapies can ameliorate accumulation, downregulate inflammatory mediator expressions, alleviate fibrosis. Fibrate statin applications exhibit beneficial effects, reducing slowing eGFR decline early However, long-term effects statins fibrates on outcomes remain controversial. Pro-protein convertase subtilisin/kexin 9 (PCSK9)-targeted minimal side kidneys seem effective inflammation improving impairment compared fibrates. In addition, LDL apheresis (LDL-A) double plasmapheresis (DFPP) promising patients severe hypercholesterolemia or drug intolerance.
Language: Английский
Citations
0
Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16
Published: March 24, 2025
Background Alpha-1-acid glycoprotein (AGP) is a vital acute phase reactant that increases when glomerular filtration impaired, making it potential biomarker of kidney disease. The urine albumin-to-creatinine ratio (UACR) sensitive indicator proteinuria and frequently used to screen for disease in its early stage. aim this study was explore their correlation order advance our understanding the mechanisms underlying damage. Methods This included 2579 female participants with serum AGP UACR from National Health Nutrition Examination Survey (2015-2018). We divided all equally into three groups based on concentration. univariate multivariate regression models were assessing between UACR. Subgroup analyses then performed effect each covariate correlation. Smoothing splines utilized nonlinear identify thresholds within it. Results After adjusting models, significantly positively associated (p<0.0001). identified specific cohort non-Hispanic Black individuals under 20 years age, characterized by BMI below 25 kg/m² waist circumference 80 cm or more. Within cohort, those hypertension sleep disorders but without hypercholesterolemia diabetes exhibited higher (p < 0.001). Furthermore, we discovered an L-shaped concentration Specifically, less than 140 mg/dL, plateaued. Conclusions first address found threshold mg/dl. could be target intervention reduce risk
Language: Английский
Citations
0
Aging and Disease, Journal Year: 2025, Volume and Issue: unknown, P. 0 - 0
Published: Jan. 1, 2025
Diabetic retinopathy (DR) is a leading cause of vision impairment and blindness among individuals with diabetes mellitus. Current clinical diagnostic criteria mainly base on visible vascular structure changes, which are insufficient to identify diabetic patients without DR (NDR) but dysfunctional retinopathy. This review focuses retinal endothelial cells (RECs), the first sense respond elevated blood glucose. As glucose rises, RECs undergo compensatory transitional phases, correspondingly altered molecules likely become biomarkers targets for early prediction treatment NDR article elaborated possible pathophysiological processes focusing summarized recently published reliable screening emerging intervention strategies Additionally, references medication selection lifestyle recommendations this population provided. aims deepen understanding REC biology pathophysiology, emphasizes importance detection intervention, points out future directions improve diagnosis reduce occurrence DR.
Language: Английский
Citations
0