Molecular Medicine Reports,
Journal Year:
2024,
Volume and Issue:
30(3)
Published: July 25, 2024
Although
microRNAs
(miRNAs/miRs)
serve
a
significant
role
in
the
autophagy
of
vascular
endothelial
cells
(ECs),
effect
miR‑92a
on
ECs
is
currently
unclear.
Therefore,
present
study
aimed
to
investigate
impact
and
underlying
molecular
processes
that
control
this
biological
activity.
Firstly,
an
model
EA.hy926
was
generated
via
treatment
with
inducer
rapamycin
(rapa‑EA.hy926
cells).
The
expression
levels
were
then
detected
by
reverse
transcription‑quantitative
PCR,
autophagic
activity
rapa‑EA.hy926
studied
overexpressing
or
inhibiting
miR‑92a.
level
evaluated
western
blot
analysis,
immunofluorescence
staining
transmission
electron
microscopy.
Dual‑luciferase
reporter
assays
used
confirm
interaction
between
FOXO3.
results
demonstrated
decreased
cell
model.
Furthermore,
overexpression
inhibition
revealed
upregulation
these
inhibited
autophagy,
whereas
knockdown
promoted
it.
It
also
confirmed
directly
bound
3'‑untranslated
region
autophagy‑related
gene
FOXO3
reduced
its
expression.
In
conclusion,
suggested
inhibits
targeting
Journal of Cellular Physiology,
Journal Year:
2024,
Volume and Issue:
239(11)
Published: July 22, 2024
The
endoplasmic
reticulum
(ER)
is
crucial
for
protein
quality
control,
and
disruptions
in
its
function
can
lead
to
various
diseases.
ER
stress
triggers
an
adaptive
response
called
the
unfolded
(UPR),
which
either
restore
cellular
homeostasis
or
induce
cell
death.
Melatonin,
a
safe
multifunctional
compound,
shows
promise
controlling
could
be
valuable
therapeutic
agent
managing
UPR.
By
regulating
mitochondrial
functions,
melatonin
helps
maintain
via
reduction
of
oxidative
stress,
inflammation,
apoptosis.
Melatonin
directly
indirectly
interfere
with
ER-associated
sensors
downstream
targets
UPR,
impacting
death,
autophagy,
molecular
repair,
among
others.
Crucially,
this
review
explores
mechanistic
role
on
diseases
including
liver
damage,
neurodegeneration,
reproductive
disorders,
pulmonary
disease,
cardiomyopathy,
insulin
resistance,
renal
dysfunction,
cancer.
Interestingly,
while
it
alleviates
burden
most
pathological
contexts,
paradoxically
stimulate
cancer
cells,
highlighting
intricate
involvement
homeostasis.
With
numerous
successful
studies
using
vivo
vitro
models,
continuation
clinical
trials
imperative
fully
explore
melatonin's
potential
these
conditions.
Biomolecules,
Journal Year:
2025,
Volume and Issue:
15(5), P. 670 - 670
Published: May 6, 2025
Cardiomyopathies
comprise
a
heterogeneous
group
of
cardiac
disorders
characterized
by
structural
and
functional
abnormalities
in
the
absence
significant
coronary
artery
disease,
hypertension,
valvular
or
congenital
defects.
Major
subtypes
include
hypertrophic,
dilated,
arrhythmogenic,
stress-induced
cardiomyopathies.
Oxidative
stress
(OS),
resulting
from
an
imbalance
between
reactive
oxygen
species
(ROS)
production
antioxidant
defenses,
has
emerged
as
key
contributor
to
pathogenesis
these
conditions.
ROS-mediated
injury
drives
inflammation,
protease
activation,
mitochondrial
dysfunction,
cardiomyocyte
damage,
thereby
promoting
remodeling
decline.
Although
numerous
studies
implicate
OS
cardiomyopathy
progression,
precise
molecular
mechanisms
remain
incompletely
defined.
This
review
provides
updated
synthesis
current
findings
on
OS-related
signaling
pathways
across
subtypes,
emphasizing
emerging
therapeutic
targets
within
redox-regulatory
networks.
A
deeper
understanding
may
guide
development
targeted
strategies
improve
clinical
outcomes
affected
patients.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
175, P. 116790 - 116790
Published: May 22, 2024
Diabetic
cardiomyopathy
(DCM)
is
a
cardiac
microvascular
complication
caused
by
metabolic
disorders.
It
characterized
myocardial
remodeling
and
dysfunction.
The
pathogenesis
of
DCM
associated
with
abnormal
cellular
metabolism
organelle
accumulation.
Autophagy
thought
to
play
key
role
in
the
diabetic
heart,
growing
body
research
suggests
that
modulating
autophagy
may
be
potential
therapeutic
strategy
for
DCM.
Here,
we
have
summarized
major
signaling
pathways
involved
regulation
DCM,
including
Adenosine
5'-monophosphate-activated
protein
kinase
(AMPK),
mechanistic
target
rapamycin
(mTOR),
Forkhead
box
subfamily
O
proteins
(FOXOs),
Sirtuins
(SIRTs),
PTEN-inducible
1
(PINK1)/Parkin.
Given
significant
further
identified
natural
products
chemical
drugs
as
regulators
treatment
This
review
help
better
understand
mechanism
promote
their
clinical
application.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(12), P. 1528 - 1528
Published: Dec. 13, 2024
Aflatoxins
(AFTs)
are
a
form
of
mycotoxins
mainly
produced
by
Aspergillus
flavus
and
parasiticus,
which
common
contaminants
in
various
agricultural
sources
such
as
feed,
milk,
food,
grain
crops.
Aflatoxin
B1
(AFB1)
is
the
most
toxic
one
among
all
AFTs.
AFB1
undergoes
bioactivation
into
AFB1-8,9-epoxide,
then
leads
to
diverse
harmful
effects
neurotoxicity,
carcinogenicity,
hepatotoxicity,
reproductive
toxicity,
nephrotoxicity,
immunotoxicity,
with
specific
molecular
mechanisms
varying
different
pathologies.
The
detoxification
great
importance
for
safeguarding
health
animals
humans
has
increasingly
attracted
global
attention.
Recent
research
shown
that
melatonin
supplementation
can
effectively
mitigate
AFB1-induced
multiple
effects.
protection
involve
inhibition
oxidative
stress,
upregulation
antioxidant
enzyme
activity,
reduction
mitochondrial
dysfunction,
inactivation
apoptotic
pathway,
blockade
inflammatory
responses,
attenuation
cytochrome
P450
enzymes’
expression
activities.
In
summary,
this
review
sheds
new
light
on
potential
role
detoxifying
agent
against
AFB1.
Further
exploration
precise
clinical
efficacy
promising
treatment
urgently
needed.
