The crucial role of hypertension in determining latent classes of metabolic syndrome in northern Iran and predictive power of these classes in non-alcoholic fatty liver: a gender-based insight DOI Creative Commons
Bahareh Amirkalali, Parvin Hassanzadeh,

Fatemeh Sheikholmolooki

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 28, 2025

Introduction This study investigates the subclasses of metabolic syndrome (Mets) and their relationship with non-alcoholic fatty liver (NAFLD) probable predictive role serum vitamin D CRP levels. Methods community-based, cross-sectional was performed on adults in framework Amol cohort prospective (AmolCPS). Mets defined as Adult Treatment Panel III criteria (ATP III) ultrasound used to diagnose NAFLD. Anthropometric blood pressure measurements were conducted, biochemical assessed after fasting. Data analysis included Latent class analysis, two-tailed χ2 statistics, one-way variance, logistic regression using Mplus (version 7.4) spss 26) softwares. Results The involved 2308 participants, a mean age 43.17 ± 12.30 years. prevalence 25.64%, three identified classes: Hypertension (HTN), without HTN (Non-HTN), Low Risk. had high probability at least four components, particularly SBP. Non-HTN especially TG low HDL but not SBP DBP. low-risk all components except women. Serum levels did significantly predict classes men, while level predicted women (OR:1.03, CI:1.004-1.067). Both HTN, increased odds NAFLD compared risk class, (HTN OR: 4.20 vs 2.94; non-HTN 5.60 3.12 men respectively). Conclusion latent northern Iran Non-HTN, low-risk, hypertension playing crucial determining these classes. These stronger predictors emerge significant classes, for among

Language: Английский

Frail hypertensive older adults with prediabetes and chronic kidney disease: insights on organ damage and cognitive performance - preliminary results from the CARYATID study DOI Creative Commons

Gaetano Santulli,

Valeria Visco, Michele Ciccarelli

et al.

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: April 10, 2024

Abstract Background Hypertension and chronic kidney disease (CKD) pose significant public health challenges, sharing intertwined pathophysiological mechanisms. Prediabetes is recognized as a precursor to diabetes often accompanied by cardiovascular comorbidities such hypertension, elevating the risk of pre-frailty frailty. Albuminuria hallmark organ damage in hypertension amplifying pre-frailty, frailty, cognitive decline older adults. We explored association between albuminuria impairment frail adults with prediabetes CKD, assessing levels based on estimated glomerular filtration rate (eGFR). Methods conducted study involving consecutive patients recruited from March 2021 2023 at ASL (local unit Italian Ministry Health) Avellino, Italy, followed up after three months. Inclusion criteria comprised age over 65 years, prior diagnosis without secondary causes, prediabetes, frailty status, Montreal Cognitive Assessment (MoCA) score < 26, CKD eGFR > 15 ml/min. Results 237 completed study. examined MoCA Score, revealing inverse correlation (r: 0.8846; p 0.0001). Subsequently, we compared Score eGFR, observing difference ( These findings were further supported multivariable regression analysis, dependent variable. Conclusions Our represents pioneering effort establish function hypertensive afflicted CKD.

Language: Английский

Citations

14
Epidemiology of Major Amputation Following Diabetic Foot Ulcer: Insights from Recent Nationwide Data in the French National Health Registry (SNDS) DOI Creative Commons
Jean‐Baptiste Bonnet, Claire Duflos,

Hélèna Huguet

et al.

Diabetes & Metabolism, Journal Year: 2025, Volume and Issue: unknown, P. 101606 - 101606

Published: Jan. 1, 2025

The out-of-hospital care pathways of people with DFU have been little studied. We used the French National Health Data System (SNDS) to collect refund and pathway data for all residents. aim this study was determine incidence major lower limb amputation (MA) associated risk factors in a population an incident DFU. included any person living diabetes primary endpoint occurrence MA within one year. considered course consumption year before after initial event. In 2018, 133,791 were included, during follow-up, performed 4,733 (3.5%). Among these MAs, 16.4% via part protocol, their first contact hospital led MA. Factors (hazard ratio, HR [95% confidence interval, CI]) were: being male (1.92 [1.78;2.08]), arteriopathy (10.16 [9.36;11.03]), psychiatric disease (1.10 [1.01;1.20]) end-stage renal (2.12 [1.93;2.33]). Regarding pathway, associations (HR [95%CI]) observed between rates more general practitioner (0.83 [0.75-0.91]), private nurse (0.88 [0.81-0.95]) diabetologist visits. Living most disadvantaged municipalities higher rate (1.17[1.06-1.29]). This is national followed by Failures precariousness several comorbidities identified, impact on risk.

Language: Английский

Citations

0
Successful Linkage of Electronic Medical Records and National Health Data System in Type 2 Diabetes Research: Methodological Insights and Implications DOI Open Access

Romane Le Goff,

Sandrine Brice,

Andrea Aparecida Contini

et al.

Pharmacoepidemiology and Drug Safety, Journal Year: 2025, Volume and Issue: 34(2)

Published: Jan. 22, 2025

ABSTRACT Purpose This study assesses success and methodological implications of linking IQVIA's Electronic Medical Records (EMR) type 2 diabetes (T2D) patients with the National Health Data System (SNDS) database, a cornerstone process in healthcare research. Methods The OREOT cohort was constituted by T2D identified IQVIA EMR from 2014 to 2018 linked indirectly SNDS database. database contains clinical records general practitioner consultations, representing ~2.8% French population claims covers over 99% population's activities. Linkage evaluated linkage rate. Baseline patients' characteristics were described for both non‐linked patients. Results Of 291 408 EMR, 244 656 (84%) successfully linked. After technical data cleaning, 239 141 (82%) finally Linked ( n = 52,267) aged 65 years more frequently male (57% 59%); half obese, most comorbidities consistent. had consultations (median 32 vs 16), cardiovascular events (12% 7%) or chronic kidney disease (10% 7%). Conclusions successful databases provides valuable insights future research other diseases requiring data. demonstrates feasibility such alignments, particularly complex health profiles extensive medical records, potential enhance real‐world quality. Despite higher prevalence baseline among patients, consistent population.

Language: Английский

Citations

0
The crucial role of hypertension in determining latent classes of metabolic syndrome in northern Iran and predictive power of these classes in non-alcoholic fatty liver: a gender-based insight DOI Creative Commons
Bahareh Amirkalali, Parvin Hassanzadeh,

Fatemeh Sheikholmolooki

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 28, 2025

Introduction This study investigates the subclasses of metabolic syndrome (Mets) and their relationship with non-alcoholic fatty liver (NAFLD) probable predictive role serum vitamin D CRP levels. Methods community-based, cross-sectional was performed on adults in framework Amol cohort prospective (AmolCPS). Mets defined as Adult Treatment Panel III criteria (ATP III) ultrasound used to diagnose NAFLD. Anthropometric blood pressure measurements were conducted, biochemical assessed after fasting. Data analysis included Latent class analysis, two-tailed χ2 statistics, one-way variance, logistic regression using Mplus (version 7.4) spss 26) softwares. Results The involved 2308 participants, a mean age 43.17 ± 12.30 years. prevalence 25.64%, three identified classes: Hypertension (HTN), without HTN (Non-HTN), Low Risk. had high probability at least four components, particularly SBP. Non-HTN especially TG low HDL but not SBP DBP. low-risk all components except women. Serum levels did significantly predict classes men, while level predicted women (OR:1.03, CI:1.004-1.067). Both HTN, increased odds NAFLD compared risk class, (HTN OR: 4.20 vs 2.94; non-HTN 5.60 3.12 men respectively). Conclusion latent northern Iran Non-HTN, low-risk, hypertension playing crucial determining these classes. These stronger predictors emerge significant classes, for among

Language: Английский

Citations

0