Myocardial microvascular function assessed by cardiovascular magnetic resonance first-pass perfusion in patients with Takotsubo syndrome

European Radiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Language: Английский

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Diagnostic possibilities of magnetic resonance imaging in the study of myocardial perfusion in ischemic conditions

Journal of clinical practice, Journal Year: 2025, Volume and Issue: unknown

Published: March 23, 2025

Cardiovascular magnetic resonance imaging (CMR) has proven to be an essential tool for assessing myocardial perfusion and diagnosing ischemia. Its high spatial resolution the absence of need radiation exposure enable accurate detection subendocardial ischemia, making it a valuable method identifying epicardial coronary artery disease (CAD). Recent advances in CMR sequences post-processing techniques have allowed shift from qualitative quantitative assessment stress CMR, significantly increasing objectivity accuracy diagnosis. Quantitative with provides ability objectively assess degree which could aid improved microvascular dysfunction (CMD). Integrating other methods, such as cine functional late gadolinium-enhanced (LGE) T1/T2 mapping tissue characterization, allows deeper understanding pathophysiology prediction outcomes various cardiovascular diseases. Thus, this review article summarizes recent studies on use diagnosis prognosis CAD, CMD, non-ischemic cardiomyopathy, emphasizing importance approach its potential clinical practice.

Language: Английский

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The impact of diabetes mellitus on cardiac function assessed by magnetic resonance imaging in patients with hypertrophic cardiomyopathy

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: Aug. 8, 2024

The adverse prognostic impact of diabetes on hypertrophic cardiomyopathy (HCM) is poorly understood. We sought to explore the underlying mechanisms in terms structural and functional remodelling HCM patients with coexisting (HCM-DM). A total 45 HCM-DM were retrospectively included. Isolated controls (HCM without diabetes) matched maximal wall thickness, age, gender distribution. Left ventricular (LV) atrial (LA) performance evaluated using cardiac magnetic resonance feature tracking strain analyses. associations between LV/LA impairment investigated by univariable multivariable linear regression. Compared isolated controls, had smaller end-diastolic volume stroke volume, lower ejection fraction, larger mass/volume ratio impaired strains all three directions (all P < 0.05). In LA parameters, presented reservoir conduit strain/strain rate Among patients, comorbidity was independently associated a low LV fraction (β = − 6.05, 0.001) global longitudinal 1.40, 0.007). Moreover, compared more myocardial fibrosis according late gadolinium enhancement, which an independent predictor radial 45.81, 0.008), circumferential 18.25, 0.003), 59.20, 2.90, 0.002). Diabetes has effects function may be important contributors severe manifestations outcomes those patients. present study strengthened evidence prevention management

Language: Английский

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Recent Advances Associated with Cardiometabolic Remodeling in Diabetes-induced Heart Failure

AJP Heart and Circulatory Physiology, Journal Year: 2024, Volume and Issue: 327(6), P. H1327 - H1342

Published: Oct. 25, 2024

Diabetes mellitus (DM) is characterized by chronic hyperglycemia, and despite intensive glycemic control, the risk of heart failure in patients with diabetes remains high. Diabetes-induced (DHF) presents a unique metabolic challenge, driven significant alterations cardiac substrate metabolism, including increased reliance on fatty acid oxidation, reduced glucose utilization, impaired mitochondrial function. These lead to oxidative stress, lipotoxicity, energy deficits, contributing progression failure. Emerging research has identified novel mechanisms involved remodeling diabetic hearts, such as autophagy dysregulation, epigenetic modifications, polyamine regulation, branched-chain amino (BCAA) metabolism. processes exacerbate dysfunction inflexibility, further impairing Therapeutic interventions targeting these pathways—such enhancing modulating optimizing ketone body utilization—show promise restoring homeostasis improving outcomes. This review explores key molecular driving highlights advanced methodologies, latest therapeutic strategies for mitigating DHF. Understanding emerging pathways offers new opportunities develop targeted therapies that address root causes diabetes.

Language: Английский

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Understanding Myocardial Ischemia: Cardiac Magnetic Resonance Insight Into Coronary Macro- and Microcirculation Pathophysiology

Current Cardiovascular Imaging Reports, Journal Year: 2024, Volume and Issue: 18(1)

Published: Dec. 1, 2024

Language: Английский

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