HORMONES, Journal Year: 2025, Volume and Issue: unknown
Published: March 21, 2025
Language: Английский
Hypertension, Journal Year: 2024, Volume and Issue: 81(7), P. 1637 - 1643
Published: May 16, 2024
Prediabetes has garnered increasing attention due to its association with cardiovascular conditions, especially hypertension, which heightens the risk of prefrailty and frailty among older individuals.
Language: Английский
Citations
32
Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)
Published: Jan. 6, 2025
Triglyceride glucose index(TyG) and a body shape index(ABSI) are both independent predictor of stroke incidence or adverse prognosis but these two indicators seldom were combined to predict. The purpose this study is evaluate whether the combination TyG ABSI better predict stroke. Based on China Health Retirement Longitudinal Study(CHARLS), 8,257 people aged 45 years older without enrolled followed up 9 years. Sociodemographic information, health status, physical examination blood data collected retrospectively. Cox regressions determine relationship between different groups incidence, using receiver operating characteristic curves diagnostic value. Meanwhile, subgroup analysis was performed investigate prediction performance among population. 672(8.14%) participants had during In adjusted multivariate cox regression model, still predictors HR 1.25(95%CI: 1.06-1.47) 1.33(95%CI: 1.06-1.68). Restricted cubic spline showed associations highest efficacy(AUC: 0.579, 95%CI: 0.553-0.597), compared TyG(AUC:0.566, 0.544-0.587) ABSI(AUC:0.533, 0.524-0.597). Kaplan-Meier that cumulative with high ABSI(TyG ≥ 8.5742, 0.0852; P < 0.0001), which incidence(HR:1.64, 95%CI:1.2-2.24). higher clinical value enabled earlier detection in general population, could be monitored intervened reduce overall burden
Language: Английский
Citations
3
Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)
Published: Feb. 6, 2025
Abstract Background The association between triglyceride-glucose (TyG), related indices and heart disease remains a topic of debate in the current literature. Existing evidence Chinese people diabetes or non-diabetes patients regarding this is limited, highlighting need for further investigation. Methods A cohort study was conducted involving 7945 participants enrolled China Health Retirement Longitudinal Study (CHARLS). incidence collected by following up 9 years. TyG, TyG with body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR) were at baseline. Multivariate Cox proportional hazards models, restricted cubic spline (RCS), Kaplan-Meier (KM) curves, subgroup analysis sensitivity used to analyze associations risk national type 2 (T2D) non-T2D respectively. Results During 9-year follow-up, 1477 (18.6%) developed disease. Our found significant positive TyG-BMI, TyG-WC, TyG-WHtR all participants. adjusted hazard ratios (HR) highest quartile compared lowest were: TyG-BMI 1.73 (95% CI: 1.47–2.03), TyG-WC 1.46 1.24–1.71), 1.31 1.11–1.54). However, alone not significantly associated In non-diabetic patients, consistent: 1.75 1.47–2.08), 1.47 1.24–1.75), 1.34 1.13–1.60). no except (HR: 1.86, 95% 1.02–3.40). Conclusions population study, higher an increased disease, showing stronger correlations. While evident only T2D underscoring necessity
Language: Английский
Citations
1
Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)
Published: Feb. 28, 2025
Cardiovascular-kidney-metabolic (CKM) syndrome has been recently proposed by American Heart Association recently. The triglyceride glucose (TyG) index and TyG-related indices combined with obesity indicators have proven to be associated the incidence of cardiovascular diseases (CVD). However, there are few studies explore whether these associations exist among people CKM stages 0–3. A total 7,364 participants from China Health Retirement Longitudinal Study were included. Cox hazard regression restricted cubic spline used analyze CVD incidence. To compare predictive performance, time-dependent Harrell's C-indices, net reclassification integrated discrimination improvement conducted. was 20.55% over nine years. TyG single all modified capable predicting RCS analyses showed that had linear relationships waist circumference (TyG-WC) or waist-to-height ratio (TyG-WHtR) still existed in stage 1, 2 3. TyG-WC (C-index: 0.621, p < 0.001) TyG-WHtR almost highest C-indices incidence, compared 0.611, body mass 0.616, 0.001). independent predictors It found better especially ratio.
Language: Английский
Citations
1
Clinical and Experimental Medicine, Journal Year: 2024, Volume and Issue: 24(1)
Published: Aug. 28, 2024
Chronic kidney disease (CKD) represents a significant global public health issue, with its incidence and prevalence escalating annually. Metabolic disorders are one of the major etiological factors CKD. This study investigates relationship between emerging metabolic index triglyceride-glucose body mass (TyG-BMI) onset Our enrolled 3,485 healthy participants (1,576 men 1,909 women), follow-up period 3 years. The primary outcome was emergence CKD, defined by an eGFR less than 60 mL/(min × 1.73 m2) or proteinuria. To examine TyG-BMI CKD relationship, we used univariate multivariate logistic regression analyses, stratified receiver operating characteristic (ROC) curves. After three-year follow-up, developed in 2% (n = 70) participants. Subjects were divided into three equal groups based on their values, from lowest to highest. adjusting for potential confounders, highest group exhibited multifactor-adjusted odds ratio (OR) 4.24 (95% CI 1.30–13.78, P 0.016) compared group. Stratified analyses revealed that association stronger among females, individuals younger years, those BMI ≥ 24 kg/m2. Furthermore, TYG-BMI effective predicting findings indicate is independent risk factor assessment may be useful early identification at high
Language: Английский
Citations
5
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: July 12, 2024
Abstract The relationship between the triglyceride glucose-body mass index (TyG-BMI) and Alzheimer’s disease (AD) pathology, cognition, brain structure remains unclear. This study aimed to investigate these associations, focusing on cerebrospinal fluid (CSF) biomarkers, cognitive measures, imaging data. Eight hundred fifty-five non-demented participants were included. Linear regression was used explore associations TyG-BMI AD structure. association risk assessed using Kaplan–Meier Cox proportional hazards models. Longitudinal relationships linear mixed-effects Mediation analyses conducted examine pathology’s potential mediating role cognition as well In analyses, higher levels associated with increased Aβ 42 decreased Tau, pTau, Tau/Aβ , pTau/Aβ pTau/Tau. Positive correlations observed mini-mental state examination (MMSE), memory (MEM), executive function (EF), volumes of hippocampus, entorhinal cortex, middle temporal regions, while negative found Disease Assessment Scale (ADAS). Longitudinally, inversely ADAS, positively MMSE, MEM, EF, entorhinal, temporal. High correlated lower (HR 0.996 [0.994, 0.999]). revealed pathology mediated Additionally, could mediate changes by influencing is
Language: Английский
Citations
4
Diabetology & Metabolic Syndrome, Journal Year: 2024, Volume and Issue: 16(1)
Published: Oct. 8, 2024
The association between the atherogenic index of plasma (AIP) and stroke risk is uncertain. Overweight obese individuals frequently develop atherosclerosis, suggesting AIP may mediate relationship body mass (BMI) risk. This study investigates whether mediates BMI-stroke evaluates interaction effects BMI on in middle-aged older Chinese adults.
Language: Английский
Citations
4
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Jan. 2, 2025
Acute kidney injury (AKI) is associated with adverse hospitalization. Previous studies have reported that an elevated triglyceride glucose (TyG) index significantly the development of AKI in patients cardiovascular disease, as well those undergoing surgery; however, potential TyG to predict following neurotrauma remains unclear. Patients diagnosed traumatic brain (TBI) Chinese tertiary hospitals between January 2014 and December 2023 were included this retrospective study. The outcome was incidence AKI. identified independent risk factor for using logistic regression propensity score matching (PSM). Finally, association further assessed multivariate regression, restricted cubic spline (RCS) subgroup analysis. present study enrolled 1,505 TBI, whom 66.45% male, average age 55.47 ± 17.32 years. 9.4%. Multiple analyses a relationship levels risk. This retained after PSM. A significant positive correlation level observed all three models constructed regression. RCS indicated linear increase increasing index. In analyses, remained stable majority population but could be influenced by sex. positively correlated TBI. As predictive biomarker, enables effective stratification customization management protocols mitigate these patients, thus enhancing clinical outcomes.
Language: Английский
Citations
0
Clinical Interventions in Aging, Journal Year: 2025, Volume and Issue: Volume 20, P. 19 - 31
Published: Jan. 1, 2025
Purpose: Research suggests that insulin resistance (IR) is associated with acute ischemic stroke (AIS) and depression. The use of insulin-based IR assessments complicated. Therefore, we explored the relationship between four non-insulin-based indices post-stroke depression (PSD). Patients Methods: A total 638 consecutive AIS patients were enrolled in this prospective cohort study. Clinical data collected to compute such as triglyceride glucose (TyG) index, glucose-body mass index (TyG-BMI), metabolic score (METS-IR), triglyceride/high-density lipoprotein cholesterol ratio (TG/HDL-C). One month post-stroke, neuropsychological conducted using 17-item Hamilton Depression Scale. Binary logistic regression analysis was performed explore PSD. Results: Ultimately, 381 completed 1-month follow-up, including 112 (29.4%) PSD group exhibited significantly higher levels compared non-PSD group. Logistic demonstrated these indicators independently occurrence, both before after adjusting for potential confounders (all P < 0.001). Tertile analyses indicated highest tertile had a greater risk occurrence than lowest indicators, even 0.05). Restricted cubic spline revealed linear dose-response In subgroup analysis, only TyG showed significant interaction diabetes (P = 0.014). area under curve values TyG-BMI, METS-IR, TG/HDL-C 0.700, 0.721, 0.711, 0.690, respectively. Conclusion: High at baseline independent factors AIS. Each exhibits predictive value aiding early identification high-risk groups. Keywords: stroke, depression, resistance,
Language: Английский
Citations
0
BMC Endocrine Disorders, Journal Year: 2025, Volume and Issue: 25(1)
Published: Jan. 26, 2025
Insulin resistance (IR) is often present in diabetes, which imposes a heavy burden on the prevention and treatment of diabetes. Triglyceride glucose index (TyG) simple, reliable reproducible detecting IR, has great advantages predicting risk The aim this study was to analyze potential association between TyG diabetes Chinese middle-aged older adults using prospective cohort design. This used longitudinal data from five waves China Health Retirement Longitudinal Study (CHARLS) conducted 2011, 2013, 2015, 2018, 2020, involving 5886 participants. We Cox proportional regression modeling investigate new-onset decision tree analysis identify high-risk groups for Finally, ROC curves were applied order construct predictive model A total 1054 (17.9%) participants developed throughout 9-year follow-up. Our utilized multivariate found significant correlation risk. also revealed nonlinear relationship risk.Receiver Operating Characteristic(ROC) curve showed that Area under curve(AUC) area 0.652 (P < 0.05). can be as factor elderly population China. In addition, there Improving insulin by regulating lipid metabolism plays an important role primary
Language: Английский
Citations
0