Clinical predictive model of new-onset atrial fibrillation in patients with acute myocardial infarction after percutaneous coronary intervention DOI Creative Commons
Xiaodan Wu, Wei Zhao, Quanwei Wang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 17, 2024

Abstract Background New-onset atrial fibrillation (NOAF) is associated with increased morbidity and mortality. Despite identifying numerous factors contributing to NOAF, the underlying mechanisms remain uncertain. This study introduces triglyceride-glucose index (TyG index) as a predictive indicator establishes clinical model. Materials Methods We included 551 patients acute myocardial infarction (AMI) without history of (AF). These were divided into two groups based on occurrence postoperative NOAF during hospitalization: group (n = 94) sinus rhythm (SR) 457). utilized regression model analyze risk establish The performance, calibration, effectiveness evaluated using receiver operational characteristics (ROC), calibration curve, decision curve analysis, impact curve. Results 94 developed hospitalization. TyG was identified an independent predictor significantly higher in group. Left (LA) diameter, age, systemic inflammatory response (SIRI), creatinine also for NOAF. Combining these build prediction resulted area under (AUC) 0.780 (95% CI: 0.888, 0.358). ROC, demonstrated that performance new nomogram satisfactory. Conclusion By incorporating model, after AMI hospitalization can be effectively predicted. Early detection improve prognosis patients.

Language: Английский

Clinical Utility of the 4S-AF Scheme in Predicting Atrial Fibrillation Recurrence after Radiofrequency Catheter Ablation DOI Creative Commons

Naiyuan Cui,

Haiwei Li, Weiping Sun

et al.

Reviews in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 26(3)

Published: March 14, 2025

The 4S-AF scheme, which comprises four domains related to atrial fibrillation (AF), stroke risk (St), symptom severity (Sy), of AF burden (Sb), and substrate (Su), represents a novel approach for structurally characterizing AF. This study aimed assess the clinical utility scheme in predicting recurrence following radiofrequency catheter ablation (RFCA). We prospectively enrolled 345 consecutive patients with who underwent initial RFCA between January 2019 December 2019. score was calculated used characterize primary outcome assessed after RFCA, defined as any documented tachyarrhythmia episode lasting at least 30 seconds. In total, (age 61 (interquartile range (IQR): 53-68) years, 34.2% female, 70.7% paroxysmal AF) were analyzed. median duration history 12 (IQR: 3-36) months, number comorbidities 2 1-3), 157 (45.5%) had left enlargement. During follow-up period 28 13-37) occurred 34.4% patients. After eliminating Sy St domains, both (hazard ratio (HR) 1.38, 95% confidence interval (CI): 1.19-1.59, p < 0.001) (2S-AF) scores (HR 1.59, CI: 1.33-1.89, independent predictors RFCA. For each domain, we found that Sb 1.84, 1.25-2.72, = 0.002) Su 1.71, 1.36-2.14, 0.001). Furthermore, (area under curve (AUC) 65.2%, 59.3-71.1) 2S-AF (AUC 66.2%, 60.2-72.1) modest ability predict is feasible evaluating undergo A higher independently associated However, discriminate high limited.

Language: Английский

Citations

0
Effect of limb ischemic preconditioning on the indirect index of insulin resistance in maintenance hemodialysis patients DOI Creative Commons
Yu Zhang,

Yushang Tang,

Linfang Xu

et al.

BMC Cardiovascular Disorders, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 29, 2025

Poor prognosis of maintenance hemodialysis (MHD) patients, including cardiovascular disease (CVD) and protein-energy wasting (PEW), is strongly associated with insulin resistance (IR). Previous studies have revealed that limb ischemic preconditioning (LIPC), as an intervention, effective in reducing inflammation oxidative stress levels patients. The aim this study was to elucidate the effects LIPC on IR indirect indices, further explore potential mechanisms indices. A retrospective analysis performed 62 patients MHD who had previously undergone ischemia (LIPC) or sham surgery (Sham). General clinical laboratory data were collected. Furthermore, assess status following indices employed: triglyceride-glucose index (TyG), body mass (TyG-BMI), triglyceride-to-high-density lipoprotein cholesterol ratio (TG/HDL-C), metabolic score (METS-IR). Inflammation indicators included high-sensitivity C-reactive protein (hs-CRP), hs-CRP /albumin (CAR), serum malondialdehyde (MDA) superoxide dismutase (SOD). Mediation conducted using Model 4 SPSS PROCESS macro version 4.1. Following a four-week experiment, (15.46 ± 3.60 vs. 10.53 5.42, p < 0.001), CAR (0.39 0.10 0.26 0.13, 0.001) MDA (8.46(6.71,9.85) 5.99(5.11,7.89), = significantly decreased group, whereas SOD (215.07(180.27,286.45) 267.76(228.32,319.54), 0.012) higher. Only (-4.93 5.68 0.16 5.39, (-0.14 0.14 -0.001 0.15, different group compared Sham group. In contrast, changes (p 0.058) 0.107) not statistically significant between groups. intra- inter-group differences four 0.05). heatmap notable correlation addition, mediation model showed inflammatory played partial mediating role improvement (TyG-BMI) by LIPC. has excellent ability inhibit peroxidation. plays process improving index.

Language: Английский

Citations

0
Association between Surrogate Insulin Resistance markers and Post-Ablation Atrial Fibrillation Recurrence: A Systematic Review and Meta-Analysis DOI
Hamed Ghoshouni, Alireza Sepehri Shamloo, Seyed Reza Mirjalili

et al.

Heart Rhythm, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
A nomogram based on the TyG index for the prediction of lower-limb venous thrombosis in patients with intracerebral hemorrhage DOI Creative Commons
Hao Zhang, Lijie Huang,

Fengda Li

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: May 19, 2025

Venous thrombosis is a serious complication that adversely impacts the prognosis of patients with intracerebral hemorrhage (ICH) and even threatens their lives. Triglyceride glucose product (TyG) index closely related to pathophysiological process cerebral venous thrombosis. A total 308 ICH were divided into training (n = 215) validation groups 93). Single factor logistic regression analysis multiple performed. Seven factors associated lower extremity identified: emergency cranial surgery, pneumonia, stroke history, age, TyG index, capryini score ≥ 10, glomerular filtration rate. The area under curve was found be 0.79 (95% CI: 0.72-0.86) in group 0.70 0.58-0.83) group. Calibration plots demonstrated strong concordance between predicted probabilities from our model observed outcomes; Decision further confirmed nomogram provides substantial clinical net benefit. By integrating recognized risk for patients, we have developed predictive aids early identification individuals at high as well supports personalized management strategies these patients.

Language: Английский

Citations

0
Independent effects of the glucose-to-glycated hemoglobin ratio on mortality in critically ill patients with atrial fibrillation DOI Creative Commons

Yuqing Fu,

Wei Xing,

Cong Xu

et al.

Diabetology & Metabolic Syndrome, Journal Year: 2024, Volume and Issue: 16(1)

Published: July 22, 2024

Abstract Background The glucose-to-glycated hemoglobin ratio (GAR) represents stress hyperglycemia, which has been closely associated with adverse outcomes in cardio-cerebrovascular diseases. No studies have examined the association between hyperglycemia and atrial fibrillation (AF) critically ill patients. This study aims to explore relationship GAR prognosis of patients AF. Methods A retrospective cohort was selected from Medical Information Mart for Intensive Care IV (MIMIC-IV) database. calculated based on fasting blood glucose glycated levels measured after admission. primary outcome 30-day mortality rate, secondary being 90-day 365-day rates. divided into tertiles, Kaplan–Meier analysis employed compare differences rates groups. Cox proportional hazards model restricted cubic splines (RCS) were utilized evaluate mortality. Subsequently, a segmented regression constructed analyze threshold effects cases where nonlinear relationships determined. Results In this cohort, second tertile exhibited lower at 30 days (10.56% vs 6.33% 14.51%), 90 (17.11% 10.09% 17.88%), 365 (25.30% 16.15% 22.72%). third tertile, risk increased by 165% (HR = 2.65, 95% CI 1.99–3.54, p < 0.001), 113% 2.13, 1.68–2.70, 70% 1.70, 0.001). patient demonstrated “J-shaped” non-linear correlation. Once exceeded 15.915, each incremental unit increase 27.2% 1.262, 1.214–1.333, Conclusion is both short-term long-term AF J-shaped relationship. Both low excessively high values indicate poor prognosis.

Language: Английский

Citations

2
A Cybertaxonomic Revision of the “Crocidura pergrisea” Species Complex with a Special Focus on Endemic Rocky Shrews: Crocidura armenica and Crocidura arispa (Soricidae) DOI Creative Commons
L.L. Voyta, Tatyana V. Petrova,

Valentina A. Panitsina

et al.

Biology, Journal Year: 2024, Volume and Issue: 13(6), P. 448 - 448

Published: June 18, 2024

The extraction of museum DNA from a unique collection samples the “Crocidura pergrisea” species complex, which comprises local endemics Central and West Asia, allowed us to determine their inter- intragroup relationships. first step this study was re-evaluation heavily damaged type specimens C. armenica via microcomputed-tomography-based cybertaxonomic approach (CTtax), enabled precise description species’ morphology; three-dimensional models cybertypes were made available through MorphoBank Repository. We developed “AProMaDesU” pipeline on basis five requirements for micro-CT-based cyber-datasets in relation mammalian collections. Our second combination several meticulous approaches morphological investigation against background cytb-based phylogeny, helped make taxonomic decision about status “pergrisea” group, e.g., arispa, armenica, serezkyensis, when results partly incongruent with molecular phylogeny. Nevertheless, under two assumptions, our findings preserved separate species-level serezkyensis arispa. In addition, we restored armenica. This is based morphospace analysis, revealed craniomandibular shape transformations within rocky shrews that them transition new area morphospace/trophic niches consequently separated other analyzed Crocidura groups.

Language: Английский

Citations

1
Insulin resistance and sarcopenia: a prognostic longitudinal link to stroke risk in middle-aged and elderly Chinese population DOI Creative Commons

Canhui Guo,

Ling He,

Yansong Tu

et al.

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Oct. 9, 2024

Stroke is the leading cause of death in middle-aged and elderly people China. Insulin resistance (IR) sarcopenia are both closely associated with metabolic diseases. However, relationship between these two indicators stroke has not been fully investigated. The aim this study was to investigate IR risk new-onset stroke.

Language: Английский

Citations

1
Clinical predictive model of new-onset atrial fibrillation in patients with acute myocardial infarction after percutaneous coronary intervention DOI Creative Commons
Xiaodan Wu, Wei Zhao, Quanwei Wang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 17, 2024

Abstract Background New-onset atrial fibrillation (NOAF) is associated with increased morbidity and mortality. Despite identifying numerous factors contributing to NOAF, the underlying mechanisms remain uncertain. This study introduces triglyceride-glucose index (TyG index) as a predictive indicator establishes clinical model. Materials Methods We included 551 patients acute myocardial infarction (AMI) without history of (AF). These were divided into two groups based on occurrence postoperative NOAF during hospitalization: group (n = 94) sinus rhythm (SR) 457). utilized regression model analyze risk establish The performance, calibration, effectiveness evaluated using receiver operational characteristics (ROC), calibration curve, decision curve analysis, impact curve. Results 94 developed hospitalization. TyG was identified an independent predictor significantly higher in group. Left (LA) diameter, age, systemic inflammatory response (SIRI), creatinine also for NOAF. Combining these build prediction resulted area under (AUC) 0.780 (95% CI: 0.888, 0.358). ROC, demonstrated that performance new nomogram satisfactory. Conclusion By incorporating model, after AMI hospitalization can be effectively predicted. Early detection improve prognosis patients.

Language: Английский

Citations

0