International Journal of Medical Sciences, Journal Year: 2024, Volume and Issue: 21(9), P. 1629 - 1639
Published: Jan. 1, 2024
The complete molecular mechanism underlying doxorubicin-induced cardiomyopathy remains incompletely elucidated. In this investigation, we engineered mice with cardiomyocyte-specific
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Oct. 14, 2024
Iron, an essential mineral in the body, is involved numerous physiological processes, making maintenance of iron homeostasis crucial for overall health. Both overload and deficiency can cause various disorders human diseases. Ferroptosis, a form cell death dependent on iron, characterized by extensive peroxidation lipids. Unlike other kinds classical unprogrammed death, ferroptosis primarily linked to disruptions metabolism, lipid peroxidation, antioxidant system imbalance. Ferroptosis regulated through transcription, translation, post-translational modifications, which affect cellular sensitivity ferroptosis. Over past decade or so, diseases have been as part their etiology, including cancers, metabolic disorders, autoimmune diseases, central nervous cardiovascular musculoskeletal Ferroptosis-related proteins become attractive targets many major that are currently incurable, some regulators shown therapeutic effects clinical trials although further validation potential needed. Therefore, in-depth analysis its molecular mechanisms may offer additional strategies prevention treatment. In this review, we discuss significance contribution etiology development along with evidence supporting targeting approach. Importantly, evaluate recent promising interventions, providing guidance future targeted treatment therapies against
Language: Английский
Citations
60
Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 70 - 70
Published: Jan. 9, 2025
Oxidative stress (OS) refers to the production of a substantial amount reactive oxygen species (ROS), leading cellular and organ damage. This imbalance between oxidant antioxidant activity contributes various diseases, including cancer, cardiovascular disease, diabetes, neurodegenerative conditions. The body’s system, mediated by signaling pathways, includes AMPK-SIRT1-FOXO pathway. In oxidative conditions, AMPK, an energy sensor, activates SIRT1, which in turn stimulates FOXO transcription factor. cascade enhances mitochondrial function, reduces damage, mitigates OS-induced injury. review provides comprehensive analysis biological roles, regulatory mechanisms, functions pathway diseases influenced OS, offering new insights methods for understanding OS pathogenesis its therapeutic approaches.
Language: Английский
Citations
4
Circulation Research, Journal Year: 2025, Volume and Issue: 136(5), P. 524 - 550
Published: Feb. 27, 2025
Cardiovascular diseases (CVDs) are experiencing a rapid surge and widely recognized as the leading cause of mortality in current aging society. Given multifactorial etiology CVDs, understanding intricate molecular cellular mechanisms is imperative. Over past 2 decades, many scientists have focused on Sirtuins, family nicotinamide adenine dinucleotide–dependent deacylases. Sirtuins highly conserved across species, from yeasts to primates, play crucial role linking diseases. participate nearly all key physiological pathological processes, ranging embryogenic development stress response aging. Abnormal expression activity exist aging-related diseases, while their activation has shown efficacy mitigating these (eg, CVDs). In terms research, this field maintained fast, sustained growth recent years, fundamental studies clinical trials. review, we present comprehensive, up-to-date discussion biological functions roles regulating cardiovascular biology CVDs. Furthermore, highlight latest advancements utilizing Sirtuin-activating compounds dinucleotide boosters potential pharmacological targets for preventing treating The unresolved issues field—from chemicobiological regulation Sirtuin-targeted CVD investigations—are also discussed. This timely review could be critical updated knowledge Sirtuin CVDs facilitating accessibility Sirtuin-targeting interventions.
Language: Английский
Citations
3
Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)
Published: Feb. 7, 2025
Cardiovascular diseases represent the principal cause of death and comorbidity among people with diabetes. Ferroptosis, an iron-dependent non-apoptotic regulated cellular characterized by lipid peroxidation, is involved in pathogenesis diabetic cardiovascular diseases. The susceptibility to ferroptosis hearts possibly related myocardial iron accumulation, abnormal metabolism excess oxidative stress under hyperglycemia conditions. Accumulating evidence suggests can be therapeutic target for This review summarizes ferroptosis-related mechanisms novel choices targeting pathways. Further study on ferroptosis-mediated cardiac injury enhance our understanding pathophysiology provide more potential choices.
Language: Английский
Citations
2
Metabolism, Journal Year: 2024, Volume and Issue: 159, P. 155979 - 155979
Published: July 20, 2024
Language: Английский
Citations
13
Autoimmunity Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 103640 - 103640
Published: Sept. 1, 2024
Language: Английский
Citations
11
Redox Biology, Journal Year: 2024, Volume and Issue: 76, P. 103321 - 103321
Published: Aug. 19, 2024
Cell death constitutes a critical component of the pathophysiology cardiovascular diseases. A growing array non-apoptotic forms regulated cell (RCD)-such as necroptosis, ferroptosis, pyroptosis, and cuproptosis-has been identified is intimately linked to various conditions. These RCD are governed by genetically programmed mechanisms within cell, with epigenetic modifications being common crucial regulatory method. Such include DNA methylation, RNA histone acetylation, non-coding RNAs. This review recaps roles modifications, RNAs in diseases, well which regulate key proteins involved death. Furthermore, we systematically catalog existing pharmacological agents targeting novel their action article aims underscore pivotal role precisely regulating specific pathways thus offering potential new therapeutic avenues that may prove more effective safer than traditional treatments.
Language: Английский
Citations
9
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 13, 2025
The pathogenesis of renal fibrosis is related to blood stasis, and the method promoting circulation removing stasis often used as treatment principle. Danshen injection (DSI) a commonly drug for in clinic. However, whether DSI slows progression or potential mechanism uncertain. We investigated models using UUO mice TGF-β stimulation HK-2 cells. Our findings revealed that Fer-1 alleviated kidney injury by ameliorating morphology pathological vivo. Besides, inhibited vivo TGF-β-induced Furthermore, ferroptosis was lessened under treatment. More importantly, active ingredients (danshensu, salvianolic acid B, protocatechuic aldehyde, caffeic tanshinone IIA) could bind SIRT1. protein levels SIRT1 GPX4 were downregulated accompanied incremental concentrations Erastin, which repaired intervention. inhibition owing reversed inhibitor EX527. Taken together, our results indicated protect against attenuate activating SIRT1/GPX4 pathway. It expected be agent treat fibrosis.
Language: Английский
Citations
1
Life Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 123565 - 123565
Published: March 1, 2025
Language: Английский
Citations
1
Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 223, P. 224 - 236
Published: Aug. 6, 2024
Language: Английский
Citations
8