The Prognostic Value of Inflammatory Indices in Acute Pulmonary Embolism

Diagnostics, Journal Year: 2025, Volume and Issue: 15(3), P. 312 - 312

Published: Jan. 29, 2025

Background: Acute pulmonary embolism (PE) is a condition with increased morbidity and mortality. It important to identify patients high mortality risk. Inflammation thrombosis are interconnected in the pathophysiology of PE. The aim study was investigate prognostic value multiple blood cellular indices such as neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte (LMR), platelet-to-lymphocyte (PLR), platelet (NLPR), systemic immune–inflammation index (SII), inflammation response (SIRI) aggregate (AISI) acute Methods: A total 157 PE confirmed by chest computed tomographic angiography (CTPA) were enrolled. These divided into two categories according simplified severity (sPESI): risk low Results: Univariate logistic regression analysis showed that right ventricle dysfunction, NLR, SII SIRI significantly associated NLR 4.32 high-risk sensitivity 57.4% specificity 65.7% (AUC = 0.635). 1086.55 55.7% 71.4% 0.614). 2.87 59% 62.9% 0.624). Multivariate demonstrated PLR NLPR independent predictors Secondly, NLPR, correlated in-hospital Based on receiver-operating characteristic (ROC) curve values 7.66 for 0.911, 85.7% sensibility 83%), 0.02 0.871, 70%), 1542.71 0.782, 72%) 5.72 0.788, 73%) could predict Conclusions: (NLR, SIRI) Right ventricular

Language: Английский

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Association of glucose to lymphocyte ratio with the risk of death in patients with atherosclerotic cardiovascular disease

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 31, 2025

Atherosclerotic cardiovascular disease (ASCVD) is a leading cause of mortality worldwide. Dysregulation glucose metabolism and inflammation are key factors in the development atherosclerosis. The glucose-to-lymphocyte ratio (GLR) comprehensive marker for assessing inflammation. This study aims to evaluate association between GLR all-cause as well (CVD) patients with ASCVD within U.S. population. retrospective cohort recruited 1,753 from 2003-2018 National Health Nutrition Examination Survey (NHANES) median follow-up 6.25 years. Mortality outcomes were determined by linkage Death Index (NDI) records up December 31, 2019. Weighted Cox proportional hazard models used assess independent risk. Restricted cubic spline (RCS) curves display relationship visually, two-segment hazards constructed on either side inflection points. Kaplan-Meier survival further mortality, subgroup analyses performed. Receiver operating characteristic curve (ROC) analysis was conducted predictive ability survival. During years, 624 deaths various causes observed, 254 CVD. regression revealed positive both CVD mortality. Based RCS, J-shaped nonlinear observed patients, an point at 3.13. When < 3.13, it showed significant negative (HR 0.65, 95% CI 0.47-0.89). ≥ 3.13 there correlation 1.13, 1.09-1.17). Subgroup across most subgroups, but weaker compared its In addition, interaction detected age relation Moreover, performance seemed superior that or lymphocytes. Our findings indicate elevated closely associated increased risk patients. Notably, exhibited pattern,

Language: Английский

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The neutrophil-to-lymphocyte ratio and the prevalence of cutaneous melanoma: a retrospective observational study of NHANES statistics spanning 1999 to 2018

Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)

Published: Feb. 8, 2025

Language: Английский

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Development and validation of a novel metabolic health-related nomogram to improve predictive performance of cardiovascular disease risk in patients with prediabetes

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 11, 2025

The prevalence of prediabetes among adults in the U.S. is three times higher than that diabetes, highlighting a greater disease burden. Both diabetes and have been demonstrated to be associated with an increased risk cardiovascular (CVD). However, research has primarily focused on limited attention CVD prediction prediabetes. Emerging 13 metabolic health-related indicators proposed optimize predictive effect patients This study aimed compare efficacy these biomarkers further develop nomogram improve performance All eligible participants National Health Nutrition Examination Survey (NHANES) 1999–2020 were enrolled this randomly assigned development validation cohorts ratio 7:3. In cohort, used predict was assessed by receiver operative characteristic (ROC) curves. Independent predictors identified multivariate logistic regression construct nomogram, internal external implemented. ROC curve triglyceride-glucose (TyG) index effective predictor [area under (AUC) = 0.694] exhibited best indices. Based independent factors regression, [including age, gender, hypertension, TyG, stress hyperglycemia (SHR), neutrophil-to-lymphocyte (NLR)] successfully constructed validated good (AUCs/C-indexes > 0.70 for all). developed reliable predicting model robust offered simple yet individualized approach

Language: Английский

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Relationship Between Dipper/Non-Dipper Pattern and Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio in Geriatric Patients with Hypertension

Online Türk Sağlık Bilimleri Dergisi, Journal Year: 2025, Volume and Issue: 10(1), P. 76 - 81

Published: March 10, 2025

Objective: Neutrophil lymphocyte ratio (NLR) and platelet (PLR) are inflammatory markers associated with poor prognoses. Non-dipper hypertension (HT) is linked to a higher risk for cardiovascular events. This study aims investigate the association between NLR PLR in geriatric patients dipper non-dipper HT. Materials Methods: A total of 124 HT were included study. Based on ambulatory blood pressure monitoring, categorized into two groups: non-dippers (n=62, Group 1) dippers 2). calculated by dividing absolute neutrophil counts, respectively, count. Results: There no significant differences sex, age, chronic conditions smoking groups (p>0.005). The was 1.96±0.66 group 1 1.67±0.68 2 (p:0.005). 146±42.2 115±34.2 (p:0.001). significantly compared (p

Language: Английский

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Association between neutrophil-to-lymphocyte ratio and all-cause and cardiovascular mortality among adults with cancer from NHANES 2005-2018: a retrospective cohort study

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: March 18, 2025

Evidence on the association between neutrophil-to-lymphocyte ratio (NLR) and all-cause cardiovascular disease (CVD) mortality in adults with cancer is limited. This study aimed to examine relationship NLR CVD cancer. A retrospective cohort included 2,639 patients U.S. from NHANES dataset (2005-2018), collecting demographic, laboratory, data. Multivariable Cox regression analysis, subgroup analysis restricted cubic spline analyses assessed associations outcomes. During a median follow-up of 77 months, 713 (27.0%) deaths occurred, including 149 (5.6%) CVD. revealed that high NLR, treated as continuous variable, was significantly correlated increased (HR, 1.09; 95% CI, 1.05-1.12; p < 0.001) 1.12; 1.05-1.19; 0.001). Meanwhile, when evaluating categorical adjusted hazard ratios (HR) for quartiles Q2 (1.6-2.2), Q3 (2.2-3), Q4 (>3) were 1.06 (95% CI: 0.83-1.34, = 0.062), 1.12 0.89-1.42, 0.334), 1.30 1.04-1.63, 0.021), respectively, compared individuals lower quartile Q1 (≤1.6). In terms mortality, HR values Q2, Q3, 0.92 0.50-1.69, 1.24 0.71-12.19, 1.76 1.04-2.97, 0.034), those Subgroup showed similar patterns (all p-values interaction > 0.05). Kaplan-Meier indicated survival rates higher RCS suggested positive linear mortality. Elevated linked risks among

Language: Английский

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The roles of neutrophils in cardiovascular diseases

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12

Published: March 19, 2025

The immune response plays a vital role in the development of cardiovascular diseases (CVDs). As crucial component innate system, neutrophils are involved initial inflammatory following injury, thereby inducing subsequent damage and promoting recovery. Neutrophils exert their functional effects tissues through various mechanisms, including activation formation neutrophil extracellular traps (NETs). Once activated, recruited to site where they release mediators cytokines. This study discusses main mechanisms associated with activity proposes potential new therapeutic targets. In this review, we systematically summarize diverse phenotypes disease regulatory different modes cell death, focus on relevance CVDs, atherosclerosis, acute coronary syndrome, myocardial ischemia/reperfusion hypertension, atrial fibrillation, heart failure, viral myocarditis. Finally, also emphasize preclinical/clinical translational significance neutrophil-targeted strategies.

Language: Английский

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Exploring the nonlinear association between cardiometabolic index and hypertension in U.S. Adults: an NHANES-based study

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 21, 2025

Hypertension is a prevalent chronic disease affecting over 1.2 billion people worldwide, representing major modifiable risk factor for cardiovascular diseases. The Waist-to-Height Ratio (WHtR) and Triglyceride to High-Density Lipoprotein Cholesterol (TG/HDL-C) ratio are established metabolic indicators linked the of Recently, Cardiometabolic Index (CMI), combining WHtR TG/HDL-C ratios, has been proposed provide comprehensive assessment health. This study investigates association between CMI hypertension using data from National Health Nutrition Examination Survey (NHANES). utilized NHANES nine cycles spanning 2001 2018, encompassing 20,049 participants aged 20. Exclusions were made individuals with incomplete or data, pregnant women. was calculated by multiplying ratio. defined according American Heart Association guidelines. relationship evaluated multivariate logistic regression analyses, additional subgroup analyses conducted based on demographic factors. Nonlinear relationships analyzed smoothing curve fitting techniques. identified significant positive correlation risk, an increase one unit in associated 9% heightened (OR: 1.09, 95% CI: 1.05, 1.13). remained across various subgroups. A nonlinear observed, critical threshold 2.64. Below this threshold, higher values progressively prevalence hypertension, whereas beyond further increases did not significantly correlate elevated hypertension. demonstrates that may serve as valuable tool early screening assessment, particularly identifying at before reaching threshold. These results underscore importance addressing health prevention management Future research should focus longitudinal studies establish causality, explore clinical utility screening, examine its applicability diverse populations.

Language: Английский

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Determination of the relationships between hyperemesis gravidarum and systemic inflammation markers: a case‒control study

BMC Pregnancy and Childbirth, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 21, 2025

We conducted our study to investigate the relationships between hyperemesis gravidarum (HEG) and inflammatory markers such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), monocyte-to-lymphocyte (MLR). A total of 150 pregnant women diagnosed with HEG controls were included in study. The data analysed demographic variables, complete blood count results, urinary ketonuria levels. found that NLR, PLR MLR significantly greater patients than (p < 0.05), indicating a potential role systemic inflammation pathophysiology HEG. Receiver operating characteristic (ROC) analysis revealed these had moderate discriminative power, suggesting their utility adjunctive diagnostic tools clinical settings. However, no correlation was severity ketonuria. can be used indicators result process

Language: Английский

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Inflammatory burden index is correlated with increased depression: a population-based study

BMC Psychiatry, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 31, 2025

Depression is intricately correlated with systemic inflammatory responses. The Inflammatory Burden Index (IBI) has recently been introduced as a comprehensive metric for evaluating inflammation. This study aims to explore the correlation between IBI and depression in general population. cross-sectional was designed analyze data from National Health Nutrition Examination Survey (NHANES) during period 1999 2018. formulated C-reactive protein×neutrophils/lymphocytes. prevalence of explored through multivariate logistic regression analyses, well subgroup, interaction, restricted cubic spline (RCS) sensitivity analyses. A total 14,557 subjects were included this study, whom, 1231 (8.5%) had depression. According RCS significantly linearly positive observed [odds ratio (OR) = 1.03, 95% confidence intervals (CI): 1.01, 1.05, P 0.007]. Subjects third tertile exhibited higher depression, 40.0% affected, compared those first (P < 0.001). consistently across all subgroups stratified analysis (all interaction > 0.05). After analyses excluding participants upper lower 2.5% IBI, remained stable (OR 1.08; 95%CI, 1.15, These findings indicate American adults. Further large-scale prospective studies are still needed role

Language: Английский

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