Differential impact of TyG and TyG-BMI indices on short- and long-term mortality in critically ill ischemic stroke patients DOI Creative Commons
Yuehua Pu, Na Xing, Ying Wang

et al.

BMC Cardiovascular Disorders, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 30, 2024

Ischemic stroke is a major contributor to global morbidity and mortality, particularly in critically ill patients intensive care units (ICUs). While advances management have improved outcomes, predicting mortality remains challenging due the involvement of complex metabolic cardiovascular factors. The triglyceride-glucose (TyG) index, marker for insulin resistance, has gained attention its potential predict adverse outcomes patients. Furthermore, TyG-BMI which combines TyG with body mass index (BMI), may offer more comprehensive measure by accounting obesity-related burden. However, comparative impact these indices on short- long-term among ischemic unclear. This retrospective cohort study analyzed data from Medical Information Mart Intensive Care IV (MIMIC-IV 3.0) database, including 1,334 were divided into four groups based quartiles, respectively. Cox proportional hazards models employed assess association 30-day, 90-day, 180-day, 1-year all-cause (ACM). Kaplan-Meier survival analysis was used compare rates across different levels. We utilized restricted cubic splines (RCS) examine between TyG, specified outcomes. establish logistic regression time periods, corresponding Receiver Operating Characteristic (ROC) curves generated. show that Higher levels associated significantly increased risk at all points, highest quartile exhibiting greatest risk. Conversely, having lower level faced heightened ACM. RCS results demonstrated did not exhibit statistically significant nonlinear relationship points. observed mortality. From ROC curve, it can be performs better short-term demonstrates superior performance revealed while alone strong predictor enhances ability finding suggests both serve as valuable predictors differences various follow-up periods. Based distinct characteristics two indicators, future research should focus selective integration clinical assessment models, tailored profiles ICU. approach could enhance precision stratification optimize patient strategies.

Language: Английский

Correlation between Triglyceride-Glucose Index and length of intensive care unit stay in sepsis DOI Open Access
Dursun Elmas, Mahmut Sami İnce

Anatolian Current Medical Journal, Journal Year: 2025, Volume and Issue: 7(2), P. 253 - 260

Published: March 21, 2025

Aims: The aim of this study is to retrospectively evaluate the impact triglyceride-glucose (TyG) index on mortality and length stay in septic patients a tertiary intensive care unit. Methods: This retrospective, descriptive cohort diagnosed with sepsis. involved 208 patients. primary was assess prognostic value TyG for predicting at 28 days following hospital admission these In addition, evaluated ICU all-cause as endpoint, secondary endpoints encompassing stay. Results: among sepsis assessed using ROC curve analysis. analysis yielded an area under (AUC) 0.798 (95% confidence interval: 0.729–0.867, p

Language: Английский

Citations

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Association between the atherogenic index of plasma and the systemic immuno-inflammatory index using NHANES data from 2005 to 2018 DOI Creative Commons
Jiayu Li, Dan Hou, Jiarong Li

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 2, 2025

Language: Английский

Citations

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Cardiometabolic index as a predictor of gallstone risk: evidence from NHANES 2017–2020 DOI Creative Commons
Hongxing Zheng, Bo Wu,

Caixiang Zhuang

et al.

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 3, 2025

Language: Английский

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Associations of healthy eating index 2020 and its components with non-alcoholic fatty liver disease in type 2 diabetes patients and the mediating roles of metabolic indicators: NHANES 2007–2018 DOI Creative Commons

Jingxiong Chen,

Haizhou Diao,

Yuling Zhang

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 9, 2025

Non-alcoholic fatty liver disease (NAFLD) represents a major public health issue, especially among individuals diagnosed with Type 2 diabetes mellitus (T2DM), where its prevalence can reach up to 70%. This research examines the relationship between Healthy Eating Index 2020 (HEI-2020) and individual components occurrence of NAFLD in T2DM patients, while also investigating potential mediating effects various metabolic indicators. Data from National Health Nutrition Examination Survey (NHANES) spanning 2007 2018 were utilized. cross-section study included 1,770 who divided into non-NAFLD groups using Fatty Liver as diagnostic tool. The HEI-2020, which assesses diet quality, was computed based on 24-h dietary recall data. Key indicators such triglyceride-glucose (TyG) index, score (MS), mean arterial pressure, uric acid levels, total cholesterol evaluated. findings indicated that higher HEI-2020 scores associated lower likelihood (odds ratio 0.978, 95% confidence interval: 0.959-0.998), strongest inverse associations observed top quartiles quality. Whole fruits, greens beans, saturated fat crucial factors. Mediation analysis demonstrated TyG index MS accounted for 5.11 36.94% NAFLD, respectively. Greater adherence is partially this association. Enhancing particularly by increasing consumption whole fruits reducing intake, may be important managing function vulnerable population.

Language: Английский

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Association between periodontitis and mortality in participants with metabolic dysfunction-associated steatotic liver disease: results from NHANES DOI Creative Commons

Zhaofu Zhang,

Qi Zheng, Yiheng Liu

et al.

BMC Oral Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 13, 2025

It has been reported that periodontitis was a risk factor for metabolic dysfunction-associated steatotic liver disease (MASLD). The aim of this study is to investigate the impact on all-cause and cause-specific mortality MASLD patients. We included 11,019 individuals with (MASLD) from National Health Nutrition Examination Survey. Multivariable Cox proportional hazards models were utilized analyze estimated hazard ratios (HRs) 95% confidence intervals (CIs) among participants different periods status. Additionally, we employed restricted cubic splines (RCS) curves explore dose-response relationship between clinical attachment level (CAL) pocket probing depth (PPD) rates. Finally, series sensitivity analyses stratification conducted test reliability robustness results. In study, moderate severe significantly increased (HR 1.29, CI 1.08-1.55; P = 0.003) cardiovascular (CVD)-related 1.41, 1.10-1.79; 0.006) participants. However, no significant effects periodontal statuses cancer observed A nationwide large-sample longitudinal indicated patients experienced higher CVD-related rates compared those or mild periodontitis.

Language: Английский

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Association between the uric acid-to-HDL-cholesterol ratio (UHR) and the risk of cardiovascular disease and dyslipidemia: a population-based study DOI Creative Commons

Yanfeng Yi,

Qin Luo,

Jingfei Chen

et al.

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 16, 2025

Language: Английский

Citations

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Comparison of TyG and modified TyG indices in predicting coronary slow flow phenomenon DOI Creative Commons

Jing Nan,

Shuai Meng,

Ruofei Jia

et al.

BMC Cardiovascular Disorders, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 30, 2025

The coronary slow flow phenomenon (CSFP) represents a common condition in patients with ischemia and non-obstructive artery disease (INOCA). triglyceride-glucose index (TyG) relative modified indices have been established to be associated CSFP. However, comparison of the clinical value TyG its predicting CSFP has not evaluated. INOCA were retrospectively enrolled. According corrected TIMI counts, divided into group non-CSFP group. A total 4,627 enrolled our study. Among them, 69 group, while 586 Demographic, risk factors, laboratory results, including indices, compared between two groups. prognostic was using area under curve (AUC). Most demographic factors comparable. For CSFP, more likely chronic kidney (CKD) (39.13% vs. 20.31%, p < 0.001) less anti-diabetic therapy (14.49% 27.13%, = 0.023). also had higher body weight (BMI) (p 0.001), levels uric acid (UA), triglyceride (TG) 0.017), cholesterol (TC) 0.016) low-density lipoprotein (LDL-C) 0.006), homocysteine 0.002). Both TyG-WC, TyG-BMI demonstrated independently multi-variable logistic analysis after adjusting other co-variables.Further receiver operating characteristic (ROC) that TyG-WC showed best performance indices. Subgroup revealed predictive consistent different subgroups except better male female patients, CONCLUSIONS: Our investigation reveals TyG, independent for than

Language: Английский

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The predictive value of endocan as a novel biomarker: an umbrella study on meta-analyses DOI Creative Commons
Sandeep Samethadka Nayak,

Daniyal Ameen,

Sara Nobakht

et al.

Systematic Reviews, Journal Year: 2025, Volume and Issue: 14(1)

Published: May 1, 2025

In recent years, endocan has emerged as a potential biomarker in various medical conditions. This multifaceted molecule, involved key processes such inflammation and endothelial dysfunction, shown promise predicting disease progression therapeutic response across spectrum of pathologies. However, the heterogeneity studies complexity endocan's role different diseases necessitate comprehensive review. umbrella review aimed to systematically synthesize evaluate evidence from multiple meta-analyses, offering view effectiveness predictive diseases. An extensive search was carried out on March 12, 2024, using following four databases: PubMed, Scopus, Web Science, Cochrane Library. The goal identify meta-analyses that assess efficacy. pooled effect size its 95% confidence interval were taken each discovered meta-analysis. Furthermore, power analyses performed robustness dependability results. additional GRADE assessment gauge epidemiological reliability findings. final analysis, 12 included current results showed there is significant correlation between higher level COVID-19 (SMD: 1.40, CI 0.21-2.58, P = 0.02), followed by chronic kidney 1.34, 0.20 2.48, < 0.01), obstructive sleep apnea 1.30, 1.06-1.54, diabetes mellitus 1.00, 0.81 1.19, coronary artery 0.99, 0.58-1.39, hypertension 0.91, 0.44-1.38, preeclampsia 0.37, 0.13-0.62, 0.01). Endocan highly promising with considerable Its relevance spans critical areas COVID-19, disease, apnea, mellitus, preeclampsia. broad applicability highlights value improving diagnostic accuracy enhancing our understanding these Clinically, incorporating testing could aid early detection, monitoring progression, refining patient management, particularly for high-risk populations. research needed fully specificity, sensitivity, overall clinical utility, paving way integration into routine healthcare practices enabling more precise, individualized treatment strategies.

Language: Английский

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Association between TyG-BMI and gout in US adults: evidence from NHANES 2007–2018 DOI Creative Commons
Rui Zhang,

Renzhe Lin,

Hengliang Zhang

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: May 3, 2025

Language: Английский

Citations

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Impact of the Triglyceride–Glucose index on all-cause and cardiovascular mortalities across different metabolic health and obesity statuses in US adults DOI Creative Commons
Yi Tao,

Zi Lin,

Feng Hu

et al.

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 14, 2025

Language: Английский

Citations

0