Inflammatory markers link triglyceride-glucose index and obesity indicators with adverse cardiovascular events in patients with hypertension: insights from three cohorts

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 8, 2025

Among hypertensive cohorts across different nations, the relationship between triglyceride-glucose index (TyG) and its conjunction with obesity metrics in relation to cardiovascular disease (CVD) incidence mortality remains be elucidated. This study enrolled 9,283, 164,357, 5,334 hypertensives from National Health Nutrition Examination Survey (NHANES), UK Biobank (UKBB), Shanghai Pudong cohort. The related outcomes for CVD were defined by multivariate Cox proportional hazards models, Generalized Additive Models Mendelian randomization analysis. Mediation analysis explored mediating role of inflammatory markers above relationships. Five measures insulin resistance linked death a U-shaped pattern, highest group having risk increases. Higher glucose triglyceride-waist height ratio (TyG-WHTR) was higher all-cause (UKBB: HR 1.21, 95%CI 1.16–1.26, NHANES: 1.17, 1.00–1.36), 1.36, 1.23–1.49, 1.32, 1.00–1.72) risks. In China cohort, triglyceride/high-density lipoprotein-cholesterol (TG/HDL_C) associated risks stroke (HR 1.31, 1.00–1.73 1.67, 1.06–2.63). Inflammation like systemic response (SIRI) C-reactive protein (CRP) partially explained these links, CRP stronger effect. Genetically predicted TyG also (OR 1.26, 1.10–1.45) risk. An elevated indices are significantly correlated an increased three national cohorts. These anticipated serve as valid predictors incident individuals hypertension.

Language: Английский

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Association of TyG index with mortality at 28 days in sepsis patients in intensive care from MIMIC IV database

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 17, 2025

The relationship between the triglyceride‒glucose (TyG) index and clinical prognosis of septic patients in intensive care units (ICUs) remains unclear. This study aimed to explore correlation TyG 28-day all-cause mortality patients. A retrospective observational cohort was conducted, including 8955 from MIMIC IV 2.2 database. primary outcome mortality. Multivariate logistic regression analysis restricted cubic spline were used assess Subgroup analyses sensitivity performed further validate robustness results. total included, 5219 (58.3%) whom male, with a mean age 66.3 (15.8) years an average 9.08 (0.70) number deaths within 28 days 1639 (18.3%). RCS curve demonstrated U-shaped (nonlinear P value = 0.0003). risk negatively associated until it decreased 9.03 (adjusted odds ratio [OR] 0.727, 95% confidence interval [CI] 0.577–0.915). However, when exceeded 9.03, for significantly increased OR 1.185, CI 1.001–1.404). These findings consistent across subgroups various analyses. Our revealed nonlinear mortality, critical point at 9.03. results suggest that may be novel important factor short-term critically ill

Language: Английский

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The association between the triglyceride‒glucose index and short-term mortality in ICU patients with sepsis-associated acute kidney injury

BMC Infectious Diseases, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 24, 2025

The triglyceride-glucose (TyG) index has emerged as a novel marker for insulin resistance and is commonly observed in patients suffering from sepsis-associated acute kidney injury (SA-AKI). This study explored the correlation between TyG short-term all-cause mortality among SA-AKI patients. We performed retrospective analysis of ICU with using data MIMIC-IV database. primary outcomes were 28-day 90-day mortality. Multivariate Cox proportional hazards regression, restricted cubic spline (RCS) models, Kaplan‒Meier (K‒M) survival analyses used to examine associations Subgroup sensitivity conducted ensure robustness findings. included 4971 patients, 2873 males (57.8%), an average age 65.4 years (± 15.8), 9.10 0.70). RCS revealed U-shaped relationship When was below 9.04, risk at both 28 days 90 reduced (adjusted HRs 0.695, 95% CI: 0.542–0.890 0.691, 0.557–0.858, respectively). In contrast, values above 9.04 associated increased mortality, though not statistically significant 1.026, 0.855–1.231 1.012, 0.863–1.188, K‒M higher rates either high (T3) or low (T1) indices than those moderate (T2) indices. Sensitivity confirmed these even after excluding diabetes, cerebrovascular diseases, stays less 2 days. significantly nonlinearly patients; however, establishing causal two requires validation through larger prospective studies.

Language: Английский

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Associations of the triglyceride-glucose index with mortality mediated by blood urea nitrogen among critically ill patients: a cohort study

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 1, 2025

Previous studies have shown that an elevated triglyceride-glucose (TyG) index is associated with all-cause mortality in patients. However, the potential mediating effect of blood urea nitrogen (BUN) within these associations has not been reported. The focus this study was to investigate BUN associations. This a retrospective cohort patients eICU Collaborative Research Database (eICU-CRD) from 208 different ICUs United States between 2014 and 2015 explored. primary endpoint 28 days ICU admission. In addition, following formula used calculate TyG index: Ln [fasting TG (mg/dL) × FBG (mg/dL)/2]. Cox regression model subgroup analysis were performed assess 28-day mortality. assessed mechanism using mediation package R 4.2.0. Of 14,414 mean age 64.1 years, 809 (5.61%) died proportion women 57.9% 8.97 ± 0.82. multivariable-adjusted model, high tertile showed even stronger association than low tertile, hazard ratio (HR) 1.27 (95% CI: 1.05, 1.53; P = 0.014). Mediation mediated 12.4% Our increased risk critically ill appeared be partially by BUN.

Language: Английский

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L-shaped association between triglyceride-glucose body mass index and short-term mortality in ICU patients with sepsis-associated acute kidney injury

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Dec. 6, 2024

Sepsis is a systemic inflammatory response syndrome, with sepsis-associated acute kidney injury (SA-AKI) being common complication. Insulin resistance (IR) closely related to the stress response, and severity of critical illness. The triglyceride-glucose body mass index (TyG-BMI) valuable tool for assessing IR. However, relationships between TyG-BMI clinical outcomes in patients SA-AKI remain unclear.

Language: Английский

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