The atherogenic index of plasma is associated with an increased risk of diabetes in non-obese adults: a cohort study

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 20, 2025

Objective This study aims to investigate the relationship between atherogenic index of plasma (AIP) and diabetes risk in Chinese non-obese adults. is important because incidence significant populations, evidence regarding this association limited. Methods We conducted a retrospective cohort with 82,977 used Cox proportional hazards regression assess baseline AIP levels incidence. also employed cubic spline functions smooth curve fitting potential nonlinear relationships. Sensitivity subgroup analyses were validate our findings. Results The median follow-up duration for these participants was 3.10 years, during which 1,041 subjects (1.25%) diagnosed diabetes. Adjusted demonstrated strong positive onset (HR 2.07; 95% CI: 1.63-2.63; p < 0.001). increased higher quartiles, especially highest (Q4) lowest (Q1) quartiles (adjusted HR 1.55; 1.27-1.89). identified risk. confirmed Furthermore, E-value analysis indicated that results robust against unmeasured confounding variables. Conclusion Our findings highlight positive, Lowering triglycerides (TG) or increasing high-density lipoprotein cholesterol (HDL-C) may help reduce

Language: Английский

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Association between the atherogenic index of plasma and long-term risk of type 2 diabetes: a 12-year cohort study based on the Japanese population

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 30, 2025

Atherosclerotic dyslipidemia is associated with an increased risk of type 2 diabetes (T2D). Although previous studies have demonstrated association between the atherogenic index plasma (AIP) and insulin resistance, there remains a scarcity large cohort investigating AIP long-term T2D in general population. This study aims to investigate potential individuals normal fasting glucose levels. retrospective included 15,453 participants. The was calculated using formula log [triglyceride (mmol/L)/high-density lipoprotein cholesterol (mmol/L)]. Cox proportional hazard regression models were employed assess risk. nonlinear examined restricted cubic spline (RCS) model. During average follow-up period 6.05 years, 373 participants developed T2D. After adjusting for confounding factors, elevated independently developing (HR 1.763, 95%CI 1.210–2.568, P = 0.003). RCS analysis revealed J-shaped risk, sharp increase when levels exceeded − 0.268. Moreover, time-dependent receiver operating characteristic consistently moderate predictability new-onset within 1 12 years. exhibits Therefore, maintaining below certain threshold (-0.268) might help prevent onset

Language: Английский

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Baseline atherogenic index of plasma and its trajectory predict onset of type 2 diabetes in a health screened adult population: a large longitudinal study

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 7, 2025

Abstract Background The Atherogenic Index of Plasma (AIP) is a novel biomarker for assessing the severity atherosclerosis and has been shown to be closely associated with risk Type 2 Diabetes Mellitus (T2DM). However, no prospective cohort study comprehensively evaluated both immediate stratification through baseline AIP long-term assessment multi-time point trajectories in health screened adults relation T2DM risk. Methods This longitudinal included data from 42,850 participants who underwent check-ups at Henan Provincial People’s Hospital between January 2018 August 2024. was calculated as logarithm ratio triglycerides (TG) high-density lipoprotein cholesterol (HDL-C). Kaplan-Meier method employed analyze incidence across different groups. A Cox model restricted cubic splines assessed dose-response relationship risk, while latent class trajectory models (LCTM) trends over multiple time points. proportional hazards were used examine quartiles, trajectories, Results During an average follow-up 47.95 months, 3,228 developed T2DM. Stratifying by quartiles revealed that higher levels increased Compared lowest quartile, highest quartile had hazard (HR) 2.10 (95% CI: 1.74, 2.53). LCTM identified three patterns AIP: low-stable group reference, medium-stable high-stable groups HRs 1.72 1.50, 1.96) 2.50 2.06, 3.03), respectively, indicating significantly elevated ( P < 0.05). Conclusion Elevated levels, medium stable high are adults.

Language: Английский

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Atherogenic index of plasma, high sensitivity C-reactive protein and incident diabetes among middle-aged and elderly adults in China: a national cohort study

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 5, 2025

The atherogenic index of plasma (AIP) and systematic inflammation, as measured by high-sensitivity C-reactive protein (hsCRP), are predictors diabetes, but their combined impacts on incident diabetes poorly understood. Using a nationally representative cohort in China, we aimed to investigate the association AIP hsCRP with among middle-aged elderly adults. This comprised 9,112 participants aged at least 45 years from 125 cities China Health Retirement Longitudinal Study who were free baseline 2011. Of these, 5,048 followed up until 2015. was calculated Log10[TG (mg/dL)/HDL-C(mg/dL)]. Multivariate logistic regression linear mixed-effect (LME) models performed evaluate associations AIP, hsCRP, well glycemic biomarkers. Receiver operating characteristic (ROC) curves used diagnostic values. We conducted mediation analysis assess direct indirect between diabetes. 489 (9.7%) cases developed during four years. Higher levels independently associated Compared lowest quartile or highest (adjusted odds ratio, aOR 2.53, 95% CI: 1.90-3.38) (aOR 2.38, 1.79-3.16) significantly joint effects showed that higher had 2.76 (2.13-3.57). LME related an increased level fasting blood glucose glycated hemoglobin. combination has better predictive efficacy (area under curve, AUC: 0.628, 0.601-0.654) for than alone. Mediation analyses high mediated 25.4% simultaneously 5.7% suggests mutual China. Our findings provide clinical implications monitoring managing mitigate development

Language: Английский

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Obesity indices and diabetes risk among hypertensive patients: insights from the China Multi-Ethnicity Cohort study

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: March 10, 2025

Background The atherogenic index of plasma (AIP) is recognized as a surrogate marker for dyslipidemia. It has been well-established that the AIP significantly associated with diabetes, and obesity known risk factor both dyslipidemia diabetes. However, relationship between well potential role in hypertensive minority populations, remains unclear. This study aimed to assess association diabetes people. Methods results cross-sectional included 9,446 participants from China Multi-Ethnicity Cohort (CMEC) study. Our suggested indices were higher diabetic patients compared those without. Moreover, logistic regression analysis quartiles an increased whether crude or adjusted models ( p &lt; 0.05). Mediation revealed mediated by body mass (BMI), waist-to-hip ratio (WHR), waist-to-height (WHtR), adiposity (BAI), through was 17.2%, 15.3%, 15.8%, 19.2%, respectively. Additionally, restricted cubic spline non-linear Conclusion In summary, Chinese, partially mediating this relationship.

Language: Английский

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The Impact of Economic Income on BMI Trajectory Groups in Chinese Elderly Individuals: A Population-Based Longitudinal Study

Nutrients, Journal Year: 2024, Volume and Issue: 17(1), P. 34 - 34

Published: Dec. 26, 2024

Objective: The objective of this study is to gain insights into the influence income on body mass index (BMI) locus in elderly population. Methods: Chinese Longitudinal Healthy Longevity and Happy Family Study (CLHLS-HF) was included at baseline (2008) for participants aged 65 years older. total number analyzed 7555. A population-based trajectory model (GBTM) used. economic level an independent variable adjusted age, gender, ethnicity, education, marriage, physical activity (Model 1), BMI value added Model 2, with a quadratic 3. sensitivity analysis adopted. Results: Three groups were identified using GBTM labeled as “overweight”, “normal”, “obesity”. After adjusting covariates increase income, risk transitioning overweight group obesity relatively increased. When values effect trajectories enhanced. performed, it found that result positive impact robust. Conclusions: higher greater individuals developing or trajectory. It suggested especially need interventions nutrition education help them acquire knowledge healthy lifestyle. provides further directions preventing controlling elderly.

Language: Английский

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Temporal changes in lipid concentrations and the prevalence of dyslipidemia among individuals with diabetes, prediabetes, and normal blood glucose from 2011 to 2015

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: Nov. 28, 2024

Dyslipidemia plays a pivotal role in the development of diabetes mellitus (DM) and other metabolic disorders. This study aimed to investigate trends lipid concentrations among Chinese participants with different blood glucose statuses—ranging from DM prediabetes (pre-DM) normal levels—between 2011 2015. Additionally, this sought provide comprehensive description potential temporal changes prevalence dyslipidemia these populations China during period. The data for were derived Health Retirement Longitudinal Study (CHARLS), encompassing two time points sample included 11,408 aged 45 years above, whereas 2015 12,224 within same age range. In study, comparative analysis revealed that individuals diagnosed pre-DM experienced significant decreases total cholesterol (TC) low-density lipoprotein (LDL-C) increase high-density (HDL-C) (P < 0.05). For pre-DM, levels residual (RC) significantly increased, atherogenic index plasma (AIP) decreased Among glucose, there was decrease TC LDL-C triglycerides (TGs), RCs, AIP Between 2015, TC, TG, LDL-C, RC, AIP, both unadjusted adjusted, higher than those opposite being true HDL-C. DM, 36.56% (95% CI: 34.49%, 38.66%), 15.78% 14.93%, 16.67%), 11.23% 10.17%, 12.36%), respectively. results present incidence urban areas between is greater patients, particularly 55–64 group. Notably, over four-year observation period, profiles improved patients patients. However, TG remained elevated, especially 45–54

Language: Английский

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