Changes in drinking levels and metabolic dysfunction-associated steatotic liver disease: a longitudinal study from the China multi-ethnic cohort study

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 11, 2025

Little is known about the associations of changes in drinking levels with newly defined metabolic dysfunction-associated steatotic liver disease (MASLD). We therefore sought to estimate between and MASLD less developed regions China. This longitudinal study included 8727 participants from China Multi-Ethnic Cohort (CMEC) regions, all participating baseline a follow-up survey. was as hepatic steatosis, along presence at least one five cardiometabolic risks, addition limiting excessive alcohol consumption. applied parametric g-formula evaluate association MASLD. further estimated fibrosis scores (AST-to-platelet ratio fibrosis-4 index) patients Compared sustained non-drinking, modest associated higher risk (Mean Ratio (MR): 1.127 [95% CI: 1.040-1.242]). MR for those transitioning non-drinking 1.065 0.983-1.169], while changing 1.059 0.965, 1.173]. Non-invasive tended increase compared non-drinking. In China, moderate Increased showed trend towards can inform policies related regions.

Language: Английский

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Lifestyles and their relative contribution to biological aging across multiple-organ systems: Change analysis from the China Multi-Ethnic Cohort study

eLife, Journal Year: 2025, Volume and Issue: 13

Published: March 7, 2025

Background: Biological aging exhibits heterogeneity across multi-organ systems. However, it remains unclear how is lifestyle associated with overall and organ-specific which factors contribute most in Southwest China. Methods: This study involved 8396 participants who completed two surveys from the China Multi-Ethnic Cohort (CMEC) study. The healthy index (HLI) was developed using five factors: smoking, alcohol, diet, exercise, sleep. comprehensive biological ages (BAs) were calculated Klemera–Doubal method based on longitudinal clinical laboratory measurements, validation conducted to select BA reflecting related diseases. Fixed effects model used examine associations between HLI or its components acceleration of validated BAs. We further evaluated relative contribution comprehension organ systems BAs quantile G-computation. Results: About two-thirds changed scores surveys. After validation, three (the cardiopulmonary, metabolic, liver BAs) identified as reflective specific diseases included analyses BA. health alterations showed a protective association all BAs, mean shift –0.19 (95% CI −0.34, –0.03) acceleration. Diet smoking major contributors negative factors, metabolic accounting for 24% 55% respectively. Conclusions: Healthy changes inversely China, diet contributing separately. Our findings highlight potential interventions decelerate identify intervention targets limit less-developed regions. Funding: work primarily supported by National Natural Science Foundation (Grant No. 82273740) Sichuan Technology Program (Natural Province, Grant 2024NSFSC0552). CMEC funded Key Research Development 2017YFC0907305, 2017YFC0907300). sponsors had no role design, analysis, interpretation, writing this article.

Language: Английский

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Hypothetical Behavioral Interventions for Mitigating the Cardiovascular Effects of Long‐Term Fine Particulate Matter Exposure: Analyses From 2 Prospective Cohorts

Journal of the American Heart Association, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Background Whether healthy behaviors can attenuate the adverse association between ambient fine particulate matter (PM 2.5 ) and cardiovascular disease (CVD) is inconclusive. METHODS AND RESULTS The parametric g‐formula was used to quantify potential reduction in PM effect on CVD under different scenarios of hypothetical behavioral interventions (including dietary patterns, physical activity, body mass index, alcohol consumption, smoking, supplements). Feasible intervention scenarios, defined basis values considered feasible previous real‐world (eg, overweight participants lose 6.69% their weight). Intensive which all are adopting completely maintain normal We also estimate joint that incorporate above behaviors. Long‐term exposure associated with incident both cohorts, risk difference per 1000 person‐years for a 5 μg/m 3 increase being 1.42 (95% CI, 1.04–1.79) UKB (UK Biobank) 2.15 1.65–2.59) Sichuan Cohort (China Multi‐Ethnic Cohort, Region). In intensive improving diet, index could significantly reduce CVD, reduced proportion ranging from 4.59% 37.22%. A 6 would by 31.47% (10.13%–57.26%) 19.75% (10.78%–42.89%) low‐pollution UK Biobank high‐pollution cohort, respectively. combination more 57.51% (21.64%–100.69%) 45.54% (22.66%–106.66%), Conclusions Healthier serve as individual‐level complementary strategies emission control minimizing health impact , whether high‐ or areas.

Language: Английский

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Association between triglyceride glucose-body mass index and the trajectory of cardio-renal-metabolic multimorbidity: insights from multi-state modelling

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 21, 2025

Although some studies have examined the association between triglyceride glucose-body mass index (TyG-BMI) and cardiovascular outcomes in cardio-renal-metabolic (CRM) background, none explored its role progression of CRM multimorbidity. In addition, prior research is limited by small sample sizes a failure to account for competitive effects other diseases. this study, data obtained from large-scale, prospective UK Biobank cohort were used. multimorbidity was defined as new-onset ischemic heart disease, type 2 diabetes mellitus, or chronic kidney disease during follow-up. Multivariable Cox regression used analyse independent TyG-BMI each (first, double, triple diseases). The C-statistic calculated model, restricted cubic spline applied assess dose–response relationship. A multi-state model investigate trajectory (from baseline [without disease] first double disease), with disease-specific analyses. This study included 349,974 participants, mean age 56.05 (standard deviation [SD], 8.08), 55.93% whom female. Over median follow-up approximately 14 years, 56,659 (16.19%) participants without developed at least one including 8451 (14.92%) who progressed 789 (9.34%) further disease. crude SD increase associated 47% higher risk 72% 95% C-statistics 0.625, 0.694, 0.764, respectively. Multi-state analysis showed 32% increased new 24% 23% those significantly onset all individual diseases (except stroke) transition Significant interactions also observed, but remained across subgroups. Sensitivity analyses, varying time intervals entering states an expanded definition (including atrial fibrillation, failure, peripheral vascular obesity, dyslipidaemia), confirmed these findings. remarkably influences Incorporating it into prevention management could important public health implications.

Language: Английский

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The Relationship between Visceral Fat Accumulation and Risk of Cardiometabolic Multimorbidity: The Roles of Accelerated Biological Aging

Nutrients, Journal Year: 2025, Volume and Issue: 17(8), P. 1397 - 1397

Published: April 21, 2025

Objectives: To investigate the association between visceral fat accumulation and risk of cardiometabolic multimorbidity (CMM) potential roles accelerated biological aging in this relationship. Methods: Using data from UK Biobank, a nationwide cohort study was conducted using available baseline body roundness index (BRI) measurement. Biological assessed Klemera–Doubal method for age phenotypic algorithms. The BRI CMM estimated Cox proportional hazards regression model, while were examined through interaction mediation analyses. Results: During median follow-up 14.52 years, 6156 cases identified. A significant observed CMM. hazard ratio (HR) 3.72 (95% confidence interval [CI]: 3.35–4.13) individuals highest quartile compared with those lowest BRI. More importantly, (AUC, 0.701; 95% CI, 0.694–0.707) demonstrated superior predictive performance relative to mass 0.657; 0.650–0.664). Furthermore, exhibited additive interactions on CMM, partially mediated Conclusions: These findings provide evidence application as novel readily accessible screening tool associated suggesting that effective management deceleration may hold promise reducing risk.

Language: Английский

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The joint effect of triglyceride-glucose related indices and depression on cardio-renal-metabolic multimorbidity among middle-aged and older Chinese adults

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Spicy food consumption and biological aging across multiple organ systems: a longitudinal analysis from the China Multi-Ethnic cohort

Nutrition Journal, Journal Year: 2025, Volume and Issue: 24(1)

Published: May 23, 2025

Language: Английский

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Associations of various healthy dietary patterns with biological age acceleration and the mediating role of gut microbiota: results from the China Multi-Ethnic Cohort study

British Journal Of Nutrition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 31

Published: Nov. 4, 2024

Abstract To investigate the associations between dietary patterns and biological aging, identify most recommended pattern for coping with aging explore potential mediating role of gut microbiota in less-developed ethnic minority regions (LEMRs). This prospective cohort study included 8288 participants aged 30-79 years from China Multi-Ethnic Cohort (CMEC). Anthropometric measurements clinical biomarkers were utilized to construct age based on Klemera Doubal’s method (KDM-BA) KDM-BA acceleration (KDM-AA). Dietary information was obtained through baseline food frequency questionnaire (FFQ). Six constructed: plant-based diet index (PDI), healthful (hPDI), unhealthful (uPDI), healthy score (HDS), Approaches Stop Hypertension (DASH), alternative Mediterranean diets (aMED). Follow-up adjusted analysis employed assess KDM-AA. Additionally, quantile G-computation evaluate significant beneficial harmful groups. In subsample 764 data 16S rRNA gene sequencing, we used causal mediation model The results showed that all associated Transitioning non-compliance compliance, DASH exhibited strongest negative association KDM-AA [ β = -0.91, 95%CI (-1.19, -0.63)]. component analyses revealed tea soybean products groups, while salt, preserved vegetables, red processed meats identified as major analysis, decreased abundance Synergistetes phylum Pyramidobacter genus possibly mediated (5.61%-9.19%). Overall, patterns, especially DASH, are negatively LEMRs. may mediate aging. Developing appropriate strategies promote

Language: Английский

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Associations of three healthy dietary patterns with homeostatic dysregulation: results from the China Multi-Ethnic Cohort study

The journal of nutrition health & aging, Journal Year: 2024, Volume and Issue: 28(12), P. 100394 - 100394

Published: Oct. 17, 2024

Language: Английский

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Lifestyles and their relative contribution to biological aging across multiple organ systems: change analysis from the China Multi-Ethnic Cohort Study

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 3, 2024

Abstract Background Biological aging exhibits heterogeneity across multi organ systems. However, it remains unclear how is lifestyle associated with overall and organ-specific which factors contribute most in Southwest China. Objective To examine the associations of healthy comprehensive biological ages most. Methods This study involved 8,396 participants who completed two surveys from China Multi-Ethnic Cohort (CMEC) Study. The index (HLI) was developed using five factors: smoking, alcohol, diet, exercise, sleep. (BAs) were calculated Klemera-Doubal method based on longitudinal clinical laboratory measurements, validation conducted to select BA reflecting related diseases. Fixed effects model used between HLI or its components acceleration validated BAs. We further evaluated relative contribution comprehension systems BAs quantile G-computation. Results About two-thirds changed scores surveys. After validation, three (the cardiopulmonary, metabolic, liver BAs) identified as reflective specific diseases included analyses BA. health alterations showed a protective association all ages, mean shift –0.19 (95%CI: –0.34, –0.03) age acceleration. Diet smoking major contributors negative metabolic accounting for 24% 55% respectively. Conclusions Healthy changes inversely China, diet contributing separately. Our findings highlight potential interventions decelerate identify intervention targets limit less-developed regions.

Language: Английский

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