Gene–Diet Interactions in High-Density Lipoprotein Cholesterol-Related Polymorphisms and Cardiovascular Disease Risk: Insights from the Korean Genome and Epidemiology Study

Nutrients, Journal Year: 2025, Volume and Issue: 17(5), P. 778 - 778

Published: Feb. 24, 2025

Background: Understanding gene-diet interactions is crucial for establishing dietary guidelines cardiovascular diseases (CVD). This study analyzed the interaction between intake and six genome-wide association (GWAS)-identified single nucleotide polymorphisms (SNP) associated with high-density lipoprotein (HDL) cholesterol levels their impact on CVD risk. Methods: A total of 68,806 participants in Korean Genome Epidemiology Study (KoGES) were analyzed. Six target SNPs (LPL: rs17482753; ABCA1: rs1883025; APOA5: rs651821; LIPC: rs1077835; CETP: rs17231506; LIPG: rs9953437) extracted from SNP genotype data. Dietary was assessed using a food frequency questionnaire. genotyping conducted Korea Biobank Array (Korean Chip), specialized platform designed GWAS blood biochemical traits population. SNP-diet risk generalized linear models (GLM). Results: Among SNPs, rs1883025 rs651821 showed significant interactions. For (ABCA1), carriers T allele exhibited reduced HDL levels. However, high-protein group, individuals T/T had significantly lower ischemic stroke compared to those low-protein group (interaction p-value = 0.044). (APOA5), also levels, but C/C (wild-type homozygotes) low-fat coronary artery disease 0.0155). Conclusions: suggests potential low patterns, particularly diets, relation These findings highlight importance personalized recommendations based genetic profiles reduce They provide basis future research aimed at developing precision nutrition targeted interventions manage hypo-HDL cholesterolemia nutrition-related risks.

Language: Английский

Intermittent fasting versus continuous caloric restriction for glycemic control and weight loss in type 2 diabetes: A traditional review

Primary care diabetes, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский