Targeting Ferroptosis and Ferritinophagy Improves Tooth Extraction Socket Healing in Type 2 Diabetes Mellitus Via Human Bone Marrow Mesenchymal Stem Cells Modulation
Published: Jan. 1, 2025
Language: Английский
Potential therapeutic targets for Alzheimer’s disease: Fibroblast growth factors and their regulation of ferroptosis, pyroptosis and autophagy
Yiwei Li,
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Chenbo Yang,
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Xiaonan Liu
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et al.
Neuroscience,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 1, 2025
Language: Английский
Exploring the key target molecules of angiogenesis in diabetic cardiomyopathy based on bioinformatics analysis
Fengli Hu,
No information about this author
Ruixue Guo,
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Yaxin Zhi
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et al.
Frontiers in Endocrinology,
Journal Year:
2025,
Volume and Issue:
16
Published: April 17, 2025
Diabetic
cardiomyopathy
has
a
very
high
incidence
and
serious
clinical
consequences,
making
it
an
urgent
problem
to
be
solved.
Angiogenesis
is
significant
phenotype
in
the
occurrence
development
of
diabetic
cardiomyopathy,
especially
damage
angiogenesis
cardiac
microvessels,
which
inextricably
linked
risk
patients.
In
current
basic
research,
there
still
lack
treatment
methods
that
directly
target
cardiomyopathy.
This
study
hopes
discover
key
molecules
related
damage,
provide
ideas
for
possible
interventions.
Sequencing
data
animals
cells
were
obtained
from
GEO
database,
differentially
expressed
genes
analyzed.
Subsequently,
angiogenesis-related
clustered
functional
pathway
analysis.
Then,
microangiogenesis
mice
changes
glucose-stimulated
HUVECs
verified,
top
three
verified
using
western
blot.
24
associated
with
found
GSE241565(human)
GSE215979(mice).
Among
them,
11
showed
same
trend
two
databases.
Then
CD31
staining
hearts
microvascular
was
impaired,
decreased
tube
formation,
wound
healing
migration
weakened.
Finally,
3
most
no
difference
between
Edn1
Lepr.
At
time,
Efnb2
significantly
increased
under
glucose
stimulation.
Combined
sequencing
animal
cell
models
differential
screened.
These
findings
not
only
elucidate
novel
molecular
axis
linking
but
also
highlight
as
potential
therapeutic
target.
Language: Английский
Low dose of micro-/nano-plastics mixture induced cardiac hypertrophy and reductive stress: the liver-heart crosstalk and hepatic-cardiac organoids-on-a-chip
Wei Cheng,
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Hange Chen,
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Yue Zhou
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et al.
Journal of Hazardous Materials,
Journal Year:
2025,
Volume and Issue:
490, P. 137686 - 137686
Published: Feb. 20, 2025
Language: Английский
Iron homeostasis and ferroptosis in muscle diseases and disorders: mechanisms and therapeutic prospects
Bone Research,
Journal Year:
2025,
Volume and Issue:
13(1)
Published: Feb. 25, 2025
Abstract
The
muscular
system
plays
a
critical
role
in
the
human
body
by
governing
skeletal
movement,
cardiovascular
function,
and
activities
of
digestive
organs.
Additionally,
muscle
tissues
serve
an
endocrine
function
secreting
myogenic
cytokines,
thereby
regulating
metabolism
throughout
entire
body.
Maintaining
requires
iron
homeostasis.
Recent
studies
suggest
that
disruptions
ferroptosis,
form
iron-dependent
cell
death,
are
essential
contributors
to
progression
wide
range
diseases
disorders,
including
sarcopenia,
cardiomyopathy,
amyotrophic
lateral
sclerosis.
Thus,
comprehensive
overview
mechanisms
ferroptosis
these
conditions
is
crucial
for
identifying
potential
therapeutic
targets
developing
new
strategies
disease
treatment
and/or
prevention.
This
review
aims
summarize
recent
advances
understanding
molecular
underlying
context
injury,
as
well
associated
disorders.
Moreover,
we
discuss
within
pathway
possible
managing
Finally,
shed
light
on
current
limitations
future
prospects
interventions
targeting
ferroptosis.
Language: Английский
Aerobic Exercise Activates Fibroblast Growth Factor 21 and Alleviates Cardiac Ischemia/Reperfusion-induced Neuronal Oxidative Stress and Ferroptosis in Paraventricular Nucleus
Molecular Neurobiology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 26, 2025
Language: Английский
DNA‐PKcs‐Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia‐Induced Cardiac Dysfunction in Type 1 Diabetes
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 25, 2025
Abstract
The
DNA‐Dependent
Protein
Kinase
catalytic
subunit
(DNA‐PKcs)
acts
as
a
principal
executor
in
the
DNA
damage
response
(DDR),
mediating
phosphorylation
of
broad
spectrum
substrates
integral
to
repair
and
apoptosis.
This
investigation
seeks
discern
possible
association
mechanisms
linking
hyperglycemia‐induced
ferroptosis
DNA‐PKcs
DCM.
data
exhibits
substantial
activation
DNAPKcs‐
dependent
DDR
mice
with
streptozotocin‐induced
However,
deletion
cardiomyocytes
notably
mitigates
damage,
enhances
heart
function
dampens
inflammatory
response.
Co‐IP/MS
analysis
subsequent
validation
experiments
demonstrate
that
directly
interacts
phosphorylates
YAP1
at
Thr226.
event
facilitates
nuclear
retention
YAP1,
where
it
intensifies
transcription
ferroptosis‐associated
genes.
Knockin
expressing
nonphosphorylatable
T226A
mutant
display
decreased
ferroptosis,
reduced
myocardial
fibrosis
improved
function.
Taken
together,
this
study
unravels
an
intracellular
stress
sensor,
perceiving
hyperglycemic
conditions
subsequently
transmitting
signal
incite
through
interplay
between
YAP1.
novel
insight
suggests
DNA‐PKcs‐mediated
could
be
promising
therapeutic
targets
for
management
Language: Английский