Relationship between stress hyperglycaemic ratio (SHR) and critical illness: a systematic review DOI Creative Commons

Guoyuan Song,

Xiujuan Liu,

Zhenyu Lu

et al.

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: May 2, 2025

Stress-induced hyperglycemia (SIH) is a physiological response to acute or chronic stress characterized by elevated blood glucose levels. It prevalent in both patients with and without diabetes, particularly those critical illnesses. The development of SIH complex interactions among catecholamines, cortisol, inflammatory mediators such as cytokines, resulting increased hepatic production insulin resistance. While mild moderate may provide protective mechanism during stress, prolonged excessive can exacerbate inflammation oxidative contributing adverse outcomes conditions myocardial infarction, heart failure, cerebrovascular diseases. stress-hyperglycemia ratio (SHR), defined the admission estimated mean (derived from glycated hemoglobin [HbA1c]), has emerged valuable tool for quantifying hyperglycemia. Unlike absolute levels, SHR accounts background provides more accurate indicator relative elevation associated illness. Extensive research demonstrated U-shaped J-shaped relationship disease outcomes, indicating that low high SHRs are mortality morbidity. shown significant predictive value cardiovascular diseases (e.g., coronary syndrome, failure), ischemic stroke, intracerebral hemorrhage), infectious sepsis, pneumonia). also plays role other conditions, pancreatitis certain cancers. ease calculating widely available HbA1c tests makes it practical prognostic marker clinical settings. This review examines between illnesses, highlighting its mechanisms across various

Language: Английский

Relationship between stress hyperglycaemic ratio (SHR) and critical illness: a systematic review DOI Creative Commons

Guoyuan Song,

Xiujuan Liu,

Zhenyu Lu

et al.

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: May 2, 2025

Stress-induced hyperglycemia (SIH) is a physiological response to acute or chronic stress characterized by elevated blood glucose levels. It prevalent in both patients with and without diabetes, particularly those critical illnesses. The development of SIH complex interactions among catecholamines, cortisol, inflammatory mediators such as cytokines, resulting increased hepatic production insulin resistance. While mild moderate may provide protective mechanism during stress, prolonged excessive can exacerbate inflammation oxidative contributing adverse outcomes conditions myocardial infarction, heart failure, cerebrovascular diseases. stress-hyperglycemia ratio (SHR), defined the admission estimated mean (derived from glycated hemoglobin [HbA1c]), has emerged valuable tool for quantifying hyperglycemia. Unlike absolute levels, SHR accounts background provides more accurate indicator relative elevation associated illness. Extensive research demonstrated U-shaped J-shaped relationship disease outcomes, indicating that low high SHRs are mortality morbidity. shown significant predictive value cardiovascular diseases (e.g., coronary syndrome, failure), ischemic stroke, intracerebral hemorrhage), infectious sepsis, pneumonia). also plays role other conditions, pancreatitis certain cancers. ease calculating widely available HbA1c tests makes it practical prognostic marker clinical settings. This review examines between illnesses, highlighting its mechanisms across various

Language: Английский

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