Long-term impact of diabetes on mortality in patients undergoing unprotected left main PCI: a propensity score-matched analysis from the BIA-LM registry DOI Creative Commons

Paweł Kralisz,

Emil Julian Dąbrowski, Sławomir Dobrzycki

et al.

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 21, 2025

There is modest data on long-term impact of diabetes left main coronary artery (LMCA) percutaneous intervention (PCI). This observational study, based the largest single-center registry LMCA PCI in Poland, evaluated survival following a real-world setting. We retrospectively analyzed 998 patients who underwent between December 27, 2007, and February 21, 2022. Diabetes insulin dependence were defined medical history, prior records, prescribed treatment. The endpoint was all-cause mortality at longest available follow-up (mean 4.2 years). Survival analysis conducted overall cohort one-to-one propensity score-matched (PSM) population. Moderation effects differences subgroups analysed predefined groups PSM cohort. median age 71 (63-79) years; 212 (28.2%) women, 250 (33.2%) had diabetes. In cohort, associated with worse prognosis (HR 1.35, 95% CI 1.03-1.76, P = 0.03). resulted 214 well-balanced pairs (median 73 years (66-79)), no significant difference (adjusted HR 1.27, 0.91-1.77, 0.16). After subgroup showed outcomes for undergoing two-stent angioplasty 3.70, 1.64-8.34, 0.002) elective 2.07, 1.29-3.31, 0.003). Conversely, among presenting myocardial infarction (MI), people better than control group 0.56, 0.35-0.90, 0.02). No observed heart failure 1.29, 0.88-1.89, 0.19), chronic kidney disease 1.08, 0.69-1.71, intravascular imaging use 1.38, 0.70-2.71, 0.35), or concomitant multivessel 1.14, 0.75-1.73, 0.53). association PCI. Sensitivity analyses diabetic treated techniques non-emergency These findings suggest safety highlight need randomized trials, especially investigating indicated high-risk subgroups.

Language: Английский

Long-term impact of diabetes on mortality in patients undergoing unprotected left main PCI: a propensity score-matched analysis from the BIA-LM registry DOI Creative Commons

Paweł Kralisz,

Emil Julian Dąbrowski, Sławomir Dobrzycki

et al.

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 21, 2025

There is modest data on long-term impact of diabetes left main coronary artery (LMCA) percutaneous intervention (PCI). This observational study, based the largest single-center registry LMCA PCI in Poland, evaluated survival following a real-world setting. We retrospectively analyzed 998 patients who underwent between December 27, 2007, and February 21, 2022. Diabetes insulin dependence were defined medical history, prior records, prescribed treatment. The endpoint was all-cause mortality at longest available follow-up (mean 4.2 years). Survival analysis conducted overall cohort one-to-one propensity score-matched (PSM) population. Moderation effects differences subgroups analysed predefined groups PSM cohort. median age 71 (63-79) years; 212 (28.2%) women, 250 (33.2%) had diabetes. In cohort, associated with worse prognosis (HR 1.35, 95% CI 1.03-1.76, P = 0.03). resulted 214 well-balanced pairs (median 73 years (66-79)), no significant difference (adjusted HR 1.27, 0.91-1.77, 0.16). After subgroup showed outcomes for undergoing two-stent angioplasty 3.70, 1.64-8.34, 0.002) elective 2.07, 1.29-3.31, 0.003). Conversely, among presenting myocardial infarction (MI), people better than control group 0.56, 0.35-0.90, 0.02). No observed heart failure 1.29, 0.88-1.89, 0.19), chronic kidney disease 1.08, 0.69-1.71, intravascular imaging use 1.38, 0.70-2.71, 0.35), or concomitant multivessel 1.14, 0.75-1.73, 0.53). association PCI. Sensitivity analyses diabetic treated techniques non-emergency These findings suggest safety highlight need randomized trials, especially investigating indicated high-risk subgroups.

Language: Английский

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