Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(3), P. 903 - 903
Published: Jan. 29, 2025
Calcific aortic stenosis (CAS) is currently recognized as the third most frequent cardiovascular disorder in persons aged above 60 years, after atherosclerotic disease and hypertension, together with its precursor sclerosis it has been found more than 30% of elderly individuals. CAS an active multifactorial process characterized by a progressive fibro-calcific remodeling thickening AV leaflets caused hemodynamic flow factors, genetic lipoprotein deposition, oxidation, chronic inflammation, immunomodulators, finally osteoblastic transformation cardiac. Herein comprehensive state-of-the-art paper presented regarding underlying pathophysiological mechanisms potential preventive strategies alternative to surgical interventional treatment.
Language: Английский