Association of platelet-to-high-density lipoprotein cholesterol ratio and its cumulative exposure with cardiovascular disease risk: a prospective cohort study in Chinese population DOI Creative Commons

Honglian Luo,

Gang Li, Yan Chen

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12

Published: May 9, 2025

Objective This study aimed to investigate the association of platelet-to-high-density lipoprotein cholesterol ratio (PHR) and its cumulative exposure with cardiovascular disease (CVD) risk. Methods The investigation utilized data from China Health Retirement Longitudinal Study (CHARLS). Platelet-to-high-density was calculated as platelet count (×10⁹/L)/high-density (mmol/L), a (Cumulative PHR) derived for longitudinal assessment. Multivariable logistic regression models were used evaluate between PHR, CVD risk across three increasing adjustments confounders. Restricted cubic splines (RCS) regressions examine if there non-linear relationships. Subgroup analyses conducted enhance reliability findings. Furthermore, predictive performance assessed using concordance index (C-index), net reclassification improvement (NRI), integrated discrimination (IDI). Results A total 7,063 participants aged 45 older included, whom 1,433 (20.29%) experienced disease. Participants had higher PHR (167.93 vs. 156.84, P < 0.001) Log (5.12 5.06, values compared non-CVD participants. revealed that independently associated [Odds (OR) per-unit: 1.30, 95% confidence interval (CI): 1.13–1.49, 0.001; OR per- standard deviation (SD): 1.13, CI: 1.06–1.21, 0.001]. showed similar associations (OR 1.34, 1.05–1.71, = 0.02). in highest quartile nearly 1.32-fold lowest (OR: 1.32, 1.10–1.57, 0.002). Addition slightly improved metrics baseline model. Conclusion Both are increased Future research should focus on clinical implementation integration into existing assessment frameworks.

Language: Английский

Association of the estimated glucose disposal rate with Heart failure mortality : a prospective cohort study DOI

Yu-Jie Lu,

Yufeng Jiang, Hai He

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Abstract Backgrounds Previous studies have found a significant correlation between the estimated glucose disposal rate (eGDR) and cardiovascular disease (CVD). However, little is known about relationship eGDR prognosis of heart failure patients. Methods The study included 1632 participants from UK biobank who were diagnosed with before December 2010 had no history cancer diabetes. formula used to calculate as follows: 21.158- (0.09 * waist circumference [cm]) - (3.407 hypertension) -0.551 HbA1C (%). Participants divided into four groups based on baseline eGDR:<4, 4-5.99, 6-7.99, ≥ 8 mg/kg/min. outcome all-cause mortality Cox proportional hazards regression model examined association event outcomes. Results During 13-year follow-up, Biobank recorded 612 deaths. Kaplan‒Meier analyses revealed that in group lowest was significantly higher (log-rank p < 0.01). patients mg/kg/min lower than 4 mg/kg/min, hazard ratio (HR) 0.63 [95% confidence interval (CI) 0.41,0.97]. Conclusions This suggests decrease associated an increase after failure. Therefore, can serve new indicator for evaluating

Language: Английский

Citations

0
Association of platelet-to-high-density lipoprotein cholesterol ratio and its cumulative exposure with cardiovascular disease risk: a prospective cohort study in Chinese population DOI Creative Commons

Honglian Luo,

Gang Li, Yan Chen

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12

Published: May 9, 2025

Objective This study aimed to investigate the association of platelet-to-high-density lipoprotein cholesterol ratio (PHR) and its cumulative exposure with cardiovascular disease (CVD) risk. Methods The investigation utilized data from China Health Retirement Longitudinal Study (CHARLS). Platelet-to-high-density was calculated as platelet count (×10⁹/L)/high-density (mmol/L), a (Cumulative PHR) derived for longitudinal assessment. Multivariable logistic regression models were used evaluate between PHR, CVD risk across three increasing adjustments confounders. Restricted cubic splines (RCS) regressions examine if there non-linear relationships. Subgroup analyses conducted enhance reliability findings. Furthermore, predictive performance assessed using concordance index (C-index), net reclassification improvement (NRI), integrated discrimination (IDI). Results A total 7,063 participants aged 45 older included, whom 1,433 (20.29%) experienced disease. Participants had higher PHR (167.93 vs. 156.84, P &lt; 0.001) Log (5.12 5.06, values compared non-CVD participants. revealed that independently associated [Odds (OR) per-unit: 1.30, 95% confidence interval (CI): 1.13–1.49, 0.001; OR per- standard deviation (SD): 1.13, CI: 1.06–1.21, 0.001]. showed similar associations (OR 1.34, 1.05–1.71, = 0.02). in highest quartile nearly 1.32-fold lowest (OR: 1.32, 1.10–1.57, 0.002). Addition slightly improved metrics baseline model. Conclusion Both are increased Future research should focus on clinical implementation integration into existing assessment frameworks.

Language: Английский

Citations

0