Joint association of estimated glucose disposal rate and systemic inflammation response index with mortality in cardiovascular-kidney-metabolic syndrome stage 0–3: a nationwide prospective cohort study DOI Creative Commons
Yuwen Chen,

Wen Lian,

Lei Wu

et al.

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 29, 2025

The Cardiovascular-Kidney-Metabolic (CKM) syndrome underscores the complex interactions among metabolic disorders, kidney disease, and cardiovascular conditions. Insulin resistance (IR) inflammation are crucial in CKM development, but their combined effect stages 0–3 remains unclear. Using data from National Health Nutrition Examination Survey (NHANES), we included 18,295 participants with 10 cycles between 1999 2018. IR was assessed using estimated glucose disposal rate (eGDR), systemic evaluated Systemic Inflammation Response Index (SIRI). primary endpoint all-cause mortality, secondary disease (CVD) mortality. Over an average follow-up period of 121 months, recorded 1,998 deaths 539 CVD deaths. Both eGDR SIRI were independent risk factors for hazard ratios (HR) 0.90 (0.86, 0.94) mortality 0.85 (0.78, 0.93) per unit increase eGDR. For SIRI, HRs 1.16 (1.11, 1.21) 1.33 (1.19, 1.46) SIRI. Compared to individuals high low levels, those levels exhibited significantly higher risks, 1.97 (1.58, 2.44) 2.35 (1.48, 3.73) Subgroup analysis revealed that impact particularly significant patients under 60 years old. In 0–3, have joint on Combining these markers can help identify high-risk early, enabling timely monitoring intervention improve outcomes. What is currently known about this topic? key research question? new? How might study influence clinical practice?

Language: Английский

Joint association of estimated glucose disposal rate and systemic inflammation response index with mortality in cardiovascular-kidney-metabolic syndrome stage 0–3: a nationwide prospective cohort study DOI Creative Commons
Yuwen Chen,

Wen Lian,

Lei Wu

et al.

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 29, 2025

The Cardiovascular-Kidney-Metabolic (CKM) syndrome underscores the complex interactions among metabolic disorders, kidney disease, and cardiovascular conditions. Insulin resistance (IR) inflammation are crucial in CKM development, but their combined effect stages 0–3 remains unclear. Using data from National Health Nutrition Examination Survey (NHANES), we included 18,295 participants with 10 cycles between 1999 2018. IR was assessed using estimated glucose disposal rate (eGDR), systemic evaluated Systemic Inflammation Response Index (SIRI). primary endpoint all-cause mortality, secondary disease (CVD) mortality. Over an average follow-up period of 121 months, recorded 1,998 deaths 539 CVD deaths. Both eGDR SIRI were independent risk factors for hazard ratios (HR) 0.90 (0.86, 0.94) mortality 0.85 (0.78, 0.93) per unit increase eGDR. For SIRI, HRs 1.16 (1.11, 1.21) 1.33 (1.19, 1.46) SIRI. Compared to individuals high low levels, those levels exhibited significantly higher risks, 1.97 (1.58, 2.44) 2.35 (1.48, 3.73) Subgroup analysis revealed that impact particularly significant patients under 60 years old. In 0–3, have joint on Combining these markers can help identify high-risk early, enabling timely monitoring intervention improve outcomes. What is currently known about this topic? key research question? new? How might study influence clinical practice?

Language: Английский

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