Clonal hematopoiesis of indeterminate potential: contribution to disease and promising interventions DOI Creative Commons

Chongjie Li,

Chunxiang Zhang, Xiuying Li

et al.

Molecular and Cellular Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

In clonal hematopoiesis of indeterminate potential (CHIP), subpopulations blood cells carrying somatic mutations expand as the individual ages, and this expansion may elevate risk cancers well cardiovascular disease. Individuals at higher CHIP therefore CHIP-associated disease can be identified through mutational profiling, apparently central role inflammation in has emerged a therapeutic target. While is often associated with negative health outcomes, emerging evidence suggests that some CHIP-related also exert beneficial effects, indicating more complex human health. This review examines current understanding epidemiology clinical significance driving its association risk. It explores mechanisms linking to other diseases, personalizing therapies against those diseases for individuals CHIP.

Language: Английский

Clonal hematopoiesis of indeterminate potential: contribution to disease and promising interventions DOI Creative Commons

Chongjie Li,

Chunxiang Zhang, Xiuying Li

et al.

Molecular and Cellular Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

In clonal hematopoiesis of indeterminate potential (CHIP), subpopulations blood cells carrying somatic mutations expand as the individual ages, and this expansion may elevate risk cancers well cardiovascular disease. Individuals at higher CHIP therefore CHIP-associated disease can be identified through mutational profiling, apparently central role inflammation in has emerged a therapeutic target. While is often associated with negative health outcomes, emerging evidence suggests that some CHIP-related also exert beneficial effects, indicating more complex human health. This review examines current understanding epidemiology clinical significance driving its association risk. It explores mechanisms linking to other diseases, personalizing therapies against those diseases for individuals CHIP.

Language: Английский

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