Estimated Glucose Disposal Rate Associated With Risk of Frailty and Likelihood of Reversion DOI Creative Commons

Dingchun Hou,

Shangjun Liu,

Yumei Sun

et al.

Journal of Cachexia Sarcopenia and Muscle, Journal Year: 2025, Volume and Issue: 16(2)

Published: April 1, 2025

ABSTRACT Background Estimated glucose disposal rate (eGDR) is a simple and effective measure for insulin resistance, which associated with higher risk of frailty. We aim to analyse the associations eGDR frailty its reversibility. Methods A population‐based longitudinal study was conducted 11 670 participants from China Health Retirement Longitudinal Study 19 355 Study. Frailty assessed by index reversibility measured transitions at baseline non‐frailty during follow‐up. The divided into Q 1 , 2 3 4 according quartiles. Multi‐state Markov model performed evaluate effects on among non‐frailty, death. Cox regression used estimate likelihood reversion. Results In Chinese population characterized median age 60 years (IQR: 54–66) 6119 women (52.43%), compared level eGDR, exposure decreased probability transitioning 22% (HR = 0.78, 95% CI: 0.69–0.88) 25% 0.75, 0.66–0.86), respectively. But levels increased 24% 1.24, 1.06–1.44), 39% 1.39, 1.19–1.64) 33% 1.33, 1.13–1.58). American 63 56–72) 189 (57.81%), 17% 0.83, 0.77–0.89), 0.76, 0.70–0.82) 46% 0.54, 0.49–0.59), revising 1.25, 1.13–1.38), 36% 1.36, 1.22–1.51) 48% 1.48, 1.30–1.69) . As shown in prospective analysis, were reversion, as evidenced dose–response relationship revealed restricted cubic spline analysis. Conclusions Higher reduced frailty, delayed transition an emerges promising predictor early detection, prognosis assessment potential therapeutic target intervention strategies.

Language: Английский

Estimated Glucose Disposal Rate Associated With Risk of Frailty and Likelihood of Reversion DOI Creative Commons

Dingchun Hou,

Shangjun Liu,

Yumei Sun

et al.

Journal of Cachexia Sarcopenia and Muscle, Journal Year: 2025, Volume and Issue: 16(2)

Published: April 1, 2025

ABSTRACT Background Estimated glucose disposal rate (eGDR) is a simple and effective measure for insulin resistance, which associated with higher risk of frailty. We aim to analyse the associations eGDR frailty its reversibility. Methods A population‐based longitudinal study was conducted 11 670 participants from China Health Retirement Longitudinal Study 19 355 Study. Frailty assessed by index reversibility measured transitions at baseline non‐frailty during follow‐up. The divided into Q 1 , 2 3 4 according quartiles. Multi‐state Markov model performed evaluate effects on among non‐frailty, death. Cox regression used estimate likelihood reversion. Results In Chinese population characterized median age 60 years (IQR: 54–66) 6119 women (52.43%), compared level eGDR, exposure decreased probability transitioning 22% (HR = 0.78, 95% CI: 0.69–0.88) 25% 0.75, 0.66–0.86), respectively. But levels increased 24% 1.24, 1.06–1.44), 39% 1.39, 1.19–1.64) 33% 1.33, 1.13–1.58). American 63 56–72) 189 (57.81%), 17% 0.83, 0.77–0.89), 0.76, 0.70–0.82) 46% 0.54, 0.49–0.59), revising 1.25, 1.13–1.38), 36% 1.36, 1.22–1.51) 48% 1.48, 1.30–1.69) . As shown in prospective analysis, were reversion, as evidenced dose–response relationship revealed restricted cubic spline analysis. Conclusions Higher reduced frailty, delayed transition an emerges promising predictor early detection, prognosis assessment potential therapeutic target intervention strategies.

Language: Английский

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