Marine Phytoplankton Bioactive Lipids and Their Perspectives in Clinical Inflammation

Marine Drugs, Journal Year: 2025, Volume and Issue: 23(2), P. 86 - 86

Published: Feb. 17, 2025

Marine phytoplankton is an emerging source of immunomodulatory bioactive lipids (BLs). Under physiological growth conditions and upon stress challenges, several eukaryotic microalgal species accumulate lipid metabolites that resemble the precursors animal mediators inflammation: eicosanoids prostaglandins. Therefore, marine could serve as a biotechnological platform to produce functional BLs with therapeutic applications in management chronic inflammatory diseases other clinical conditions. However, be commercially competitive, lipidic precursor yields should enhanced. Beside tailoring cultivation native producers, genetic engineering feasible strategy accrue production introduce heterologous biosynthetic pathways hosts. Here, we present state-of-the-art research on from discuss synthetic biology approaches boost their light-driven biosynthesis.

Language: Английский

Engineering of the fast-growing cyanobacterium Synechococcus sp. PCC 11901 to synthesize astaxanthin

Biotechnology for Biofuels and Bioproducts, Journal Year: 2025, Volume and Issue: 18(1)

Published: Feb. 28, 2025

Abstract Background Astaxanthin is a red pigment required by feed, nutraceutical, and cosmetic industries for its pigmentation antioxidant properties. This carotenoid one of the main high-value products that can nowadays be derived from microalgae cultivation, raising important industrial interest. However, state-of-the-art astaxanthin production cultivation green alga Haematococcus pluvialis (or lacustris ), which faces high costs low yield. Hence, alternative efficient sources need to developed, novel biotechnological solutions must found. The recently discovered cyanobacterium, Synechococcus sp. PCC 11901 promising photosynthetic platform large-scale products, but potential has yet thoroughly tested. Results In this study, cyanobacterium was engineered first time our knowledge produce astaxanthin, ketocarotenoid, expressing recombinant β-ketolase (bKT) β-hydroxylase enzymes (CtrZ). During photoautotrophic growth, bKT-CtrZ transformed strain (called BC) accumulated above 80% total carotenoid. Moreover, BC cells grew faster than wild-type (WT) in light continuous bubbling with CO 2 -enriched air. reached stationary phase after only 4 days growth an airlift 80-mL photobioreactor, producing 7 g/L dry biomass, ~ 10 mg/L/day more other -consuming multi-engineered systems. addition, were cultivated 330-L photobioreactor link lab-scale experiments scale-up. Conclusions volumetric productivity achieved, mg/L/day, exceeds previously reported pluvialis, standard microalgal species used at level production, or strains ketocarotenoids. Overall, work identifies new route on scale.

Language: Английский

Study of three Scenedesmaceae strains: morphology, molecular phylogeny, growth and carotenogenesis

World Journal of Microbiology and Biotechnology, Journal Year: 2025, Volume and Issue: 41(4)

Published: March 28, 2025

Language: Английский