lncRNA HIF1A-AS2 acts as an oncogene to regulate malignant phenotypes in cervical cancer DOI Creative Commons
Yang Liu, Yunyan Zhang, Chen Cha

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 27, 2025

Background Long noncoding RNAs (lncRNAs) HIF1A-AS2 is upregulated in multiple human cancers and are associated with various aspects of tumor progression. However, the molecular mechanisms cervical cancer (CC) remain largely unknown. In this study, we aim to investigate expression pattern signaling pathways CC. Methods The study included a group 20 CC patients, from whom tissue specimens were collected. Additionally, three distinct cell lines (HeLa, SiHa, CaSki) utilized. Quantitative real-time PCR (qRT-PCR) was used assess transcript levels these samples. Functional studies performed by CCK-8, Transwell Apoptosis assays. Databases including JASPAR, miRDB Targetscan for transcription factor or target miRNA prediction, subsequent dual luciferase activity assay, chromatin immunoprecipitation (ChIP) Ago2 (RIP) also adopted validation. Results demonstrated that elevated clinical cultured comparison normal controls. Knockdown notably inhibited proliferation invasion cells, while inducing apoptosis. contrast, overexpression promoted cellular suppressed It identified c-Jun functions as factor, activating expression. found serve sponge miR-34b-5p, negatively regulating its Furthermore, controlled radixin (RDX) sponging miR-34b-5p pathway. Conclusion Our findings indicate c-Jun-activated acts an oncogenic radixin. These suggest might be viable promising therapeutic treatment.

Language: Английский

Long non-coding RNA mediated drug resistance in breast cancer DOI
Deepshikha Singh, Yehuda G. Assaraf, Rajesh N. Gacche

et al.

Drug Resistance Updates, Journal Year: 2022, Volume and Issue: 63, P. 100851 - 100851

Published: July 1, 2022

Language: Английский

Citations

99
Immune-related lncRNAs as predictors of survival in breast cancer: a prognostic signature DOI Creative Commons
Wei Ma,

Fangkun Zhao,

Xinmiao Yu

et al.

Journal of Translational Medicine, Journal Year: 2020, Volume and Issue: 18(1)

Published: Nov. 23, 2020

Abstract Background Breast cancer is a highly heterogeneous disease, this poses challenges for classification and management. Long non-coding RNAs play acrucial role in the breast cancersdevelopment progression, especially tumor-related immune processes which have become most rapidly investigated area. Therefore, we aimed at developing an immune-related lncRNA signature to improve prognosis prediction of cancer. Methods We obtained patient samples corresponding clinical data from The Cancer Genome Atlas (TCGA) database. Immune-related lncRNAs were screened by co-expression analysis genes downloaded Immunology Database Analysis Portal (ImmPort). Clinical randomly separated into training testing sets. In set, univariate Cox regression LASSO utilized build prognostic signature. was validated whole cohorts Kaplan–Meier log-rank test, time-dependent ROC curve analysis, principal component andmultivariate analyses. Results A total 937 immune- related identified, 15 candidate significantly associated with overall survival (OS). Eight these (OTUD6B-AS1, AL122010.1, AC136475.2, AL161646.1, AC245297.3, LINC00578, LINC01871, AP000442.2) selected establishment risk model. OS patients low-risk group higher than that high-risk ( p = 1.215e − 06 set; 0.0069 validation 1.233e 07 cohort). revealed AUCs first, eighth, tenth year 0.812, 0.81, 0.857, respectively, 0.615, 0.68, 0.655 0.725, 0.742, 0.741 cohort. Multivariate indicated model reliable independent indicator set (HR 1.432; 95% CI 1.204–1.702, < 0.001), 1.162; 1.004–1.345, 0.044), 1.240; 1.128–1.362, 0.001). GSEA strong connection between biological pathways. Conclusions constructed verified robust 8 survival.

Language: Английский

Citations

86
Dual relationship between long non-coding RNAs and STAT3 signaling in different cancers: New insight to proliferation and metastasis DOI
Milad Ashrafizadeh, Mohammad Gholami, Sepideh Mirzaei

et al.

Life Sciences, Journal Year: 2021, Volume and Issue: 270, P. 119006 - 119006

Published: Jan. 7, 2021

Language: Английский

Citations

67
The role of M6A modification in the regulation of tumor-related lncRNAs DOI Creative Commons
Yufei Lan,

Boyang Liu,

Hongbo Guo

et al.

Molecular Therapy — Nucleic Acids, Journal Year: 2021, Volume and Issue: 24, P. 768 - 779

Published: April 9, 2021

N6-methyladenosine (m6A) is the most abundant modification in eukaryotic cells, and it regulates RNA transcription, processing, splicing, degradation, translation. Long non-coding RNAs (lncRNAs), as transcriptional products with no or limited protein coding ability more than 200 nt length, play an important role epigenetic modification, mRNA stability, translation, other biological functions. Extensive studies have shown that both m6A lncRNAs are involved pathogenesis of various diseases, such kinds cancers, heart failure, Alzheimer's disease, periodontitis, human abdominal aortic aneurysm, obesity. To date, has been identified function enrichment regulation lncRNAs. In this review, we summarize tumor-related Moreover, discuss potential applications possible future directions field.

Language: Английский

Citations

65
GAS5 lncRNA: A biomarker and therapeutic target in breast cancer DOI
Lakshmi Thangavelu, Ehssan Moglad, Gaurav Gupta

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 260, P. 155424 - 155424

Published: June 20, 2024

Language: Английский

Citations

11
The expression of the lncRNAs USP30-AS1, ELFN1-AS1, GAS8-AS1, and SNHG11 in breast cancer samples from Iranian patients from 2014 to 2019: a cross-sectional study DOI Creative Commons
Ghazal Orak, Zahra Orak Chahartangi, Zahra Nazeri

et al.

BMC Research Notes, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 5, 2025

Breast cancer is a widely prevalent and life-threatening malignancy that affects women worldwide. The identification of novel molecular markers associated with tumor progression highly important for enhancing early detection, tailoring treatment approaches, monitoring therapeutic outcomes. In this study, we investigated the expression patterns four long noncoding RNAs (lncRNAs): USP30 antisense RNA1 (USP30-AS1), ELFN1 (ELFN1-AS1), GAS8 (GAS8-AS1), small nucleolar RNA host gene 11 (SNHG11). breast specimens, USP30-AS1 GAS8-AS1 was decreased, whereas ELFN1-AS1 SNHG11 increased in tissues compared adjacent noncancer tissues. Decreased levels were smaller size, lower grade stage, absence lymphatic vascular invasion. Lower positive estrogen progestin receptor status. Elevated lacked P53 mutation. These changes suggest their promise as biomarkers distinguishing between cancerous noncancerous

Language: Английский

Citations

1
Non-coding RNAs as key regulators of epithelial-mesenchymal transition in breast cancer DOI Creative Commons
Jing Peng,

Wenhui Liu,

Jinwei Tian

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: March 25, 2025

This study examines the critical role of non-coding RNAs (ncRNAs) in regulating epithelial-mesenchymal transition (EMT) breast cancer, a prevalent malignancy with significant metastatic potential. EMT, wherein cancer cells acquire mesenchymal traits, is fundamental to metastasis. ncRNAs—such as microRNAs (miRNAs), long (lncRNAs), and circular (circRNAs)—modulate EMT by influencing gene expression signaling pathways, affecting cell migration invasion. review consolidates recent findings on ncRNA-mediated regulation explores their diagnostic therapeutic Specifically, miRNAs inhibit EMT-related transcription factors, while lncRNAs circRNAs regulate through interactions miRNAs, impacting progression. Given influence ncRNAs metastasis resistance, advancing ncRNA-based biomarkers treatments holds promise for improving outcomes.

Language: Английский

Citations

1
The roles of long noncoding RNAs in breast cancer metastasis DOI Creative Commons
Lingxia Liu, Yu Zhang, Jun Lü

et al.

Cell Death and Disease, Journal Year: 2020, Volume and Issue: 11(9)

Published: Sept. 14, 2020

Abstract Breast cancer is the most significant threat to female health. metastasis major cause of mortality in breast patients. To fully unravel molecular mechanisms that underlie cell critical for developing strategies improve survival and prognosis Recent studies have revealed long noncoding RNAs (lncRNAs) are involved through a variety molecule mechanisms, though precise functional details these lncRNAs yet be clarified. In present review, we focus on functions invasion metastasis, with particular emphasis properties, regulatory factors, therapeutic promise, as well future challenges studying lncRNA.

Language: Английский

Citations

69
Long noncoding RNAs and their link to cancer DOI Creative Commons
Justine M. Grixti, Duncan Ayers

Non-coding RNA Research, Journal Year: 2020, Volume and Issue: 5(2), P. 77 - 82

Published: May 13, 2020

The central dogma of molecular biology, developed from the study simple organisms such as

Language: Английский

Citations

67
lncRNA TCL6 correlates with immune cell infiltration and indicates worse survival in breast cancer DOI
Yaqiong Zhang,

Zhaoyun Li,

Meifang Chen

et al.

Breast Cancer, Journal Year: 2020, Volume and Issue: 27(4), P. 573 - 585

Published: Jan. 20, 2020

Language: Английский

Citations

66