Functional dyeing of cellulose macromolecule/synthetic fibers two-component fabrics with sustainable microbial prodigiosins

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 278, P. 134964 - 134964

Published: Aug. 23, 2024

Language: Английский

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Remodeled tumor immune microenvironment (TIME) parade via natural killer cells reprogramming in breast cancer

Life Sciences, Journal Year: 2023, Volume and Issue: 330, P. 121997 - 121997

Published: Aug. 2, 2023

Language: Английский

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Complex of intratumoral mycobiome and bacteriome predicts the recurrence of laryngeal squamous cell carcinoma

Applied and Environmental Microbiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

ABSTRACT Dysbiosis of intratumoral fungal and bacterial communities is associated with poor prognosis in various cancers. However, the mycobiome characteristics laryngeal squamous cell carcinoma (LSCC) its correlation recurrence have not yet been investigated. The 80 LSCC samples was characterized using internal transcribed spacer sequencing, encompassing both tumor tissues their matched para-cancerous tissues. bacteriome further identified 16S rRNA sequencing. These two microbial were analyzed bioinformatics statistical methods to determine potential recurrence. alpha diversity tumors higher compared that ( P < 0.001). A significant difference overall community patterns between observed based on Bray-Curtis dissimilarity presence Alloprevotella , Porphyromonas Candida Fusarium exhibited a alcohol consumption. relative abundance Penicillium Exophiala Aspergillus mycobiome, as well Peptostreptococcus significantly increased risk 0.05). six microorganisms can combine form complex which may independently contribute patients when enriched within (hazard ratio = 6.844, 0.01). Intratumoral fungi bacteria be valuable indicators for assessing LSCC, indicating targets therapeutic intervention. IMPORTANCE Our results revealed dysbiosis microbiota, including overgrowth several or organisms, substantially linked LSCC. Drinking habits might alter microbiota influence We also explored method potentially predict from novel perspective. findings could offer insights into etiology pave way prevent treat

Language: Английский

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Differential Signaling Pathways in Medulloblastoma: Nano-biomedicine Targeting Non-coding Epigenetics to Improve Current and Future Therapeutics

Current Pharmaceutical Design, Journal Year: 2023, Volume and Issue: 30(1), P. 31 - 47

Published: Dec. 28, 2023

Medulloblastomas (MDB) are malignant, aggressive brain tumors that primarily affect children. The survival rate for children under 14 is approximately 72%, while ages 15 to 39, it around 78%. A growing body of evidence suggests dysregulation signaling mechanisms and noncoding RNA epigenetics play a pivotal role in this disease.

Language: Английский

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Cancer therapy with the viral and bacterial pathogens: The past enemies can be considered the present allies

Life Sciences, Journal Year: 2024, Volume and Issue: 349, P. 122734 - 122734

Published: May 22, 2024

Language: Английский

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Advancing (-)-Premarineosin A as a Potent Antimalarial Therapeutic via Metabolic Engineering and Late-Stage Derivatization

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Abstract Despite modern preventative and curative efforts, malaria has remained a major global health crisis. In 2023 alone, was responsible for an estimated 263 million cases 597,000 deaths. To complicate this issue, the causative Plasmodium parasites are becoming more resistant to available therapeutics, making it difficult treat prevent disease progression. Hence, discovery of new antimalarial drugs is crucial mitigating One promising contender natural product premarineosin A, intermediate marineosin biosynthetic pathway that exhibits potent selective activity against both chloroquine-sensitive multi-drug-resistant strains. However, its complex chemical structure low production titers have prevented further exploration. improve access metabolite, we identified gene cluster (-)-premarineosin A in Streptomyces eitanensis. Metabolic engineering approaches increased from trace levels nearly 35 mg/L, which enabled semi-synthetic biocatalytic derivatization scaffold. Late-stage C-H bromination B-ring resulted highly (EC 50 < 5 nM) compound with cytotoxicity. These findings report progress toward sustainable first structure-activity relationship study unique scaffold search improved therapeutics.

Language: Английский

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A comprehensive review and in silico analysis of the role of survivin (BIRC5) in hepatocellular carcinoma hallmarks: A step toward precision

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143616 - 143616

Published: April 1, 2025

Language: Английский

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Advanced Technologies for Large Scale Supply of Marine Drugs

Marine Drugs, Journal Year: 2025, Volume and Issue: 23(2), P. 69 - 69

Published: Feb. 7, 2025

Marine organisms represent a source of unique chemical entities with valuable biomedical potentialities, broad diversity, and complexity. It is essential to ensure reliable sustainable supply marine natural products (MNPs) for their translation into commercial drugs other products. From structural point view few exceptions, MNPs pharmaceutical importance derive from the so-called secondary metabolism organisms. When production strategies rely on macroorganisms, harvesting or culturing coupled extraction procedures frequently remain only alternative producing these compounds an industrial scale. Their can often be implemented laboratory scale cultures bacterial, fungal, microalgal sources. However, diverse approach, combining traditional methods modern synthetic biology biosynthesis strategies, must considered invertebrate MNPs, as they are usually naturally accumulated in very small quantities. This review offers comprehensive examination various addressing challenges related supply, synthesis, scalability. also underscores recent biotechnological advancements that likely transform current industrial-scale manufacturing pharmaceuticals derived

Language: Английский

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Prodigiosin As N-heterocyclic compound: Production Optimization, Bioactivity Evaluation, and In-Silico Docking Against Key Enzymes Related to Inflammation, Obesity, Diabetes, and the Insulin Signaling Pathway

Enzyme and Microbial Technology, Journal Year: 2025, Volume and Issue: unknown, P. 110639 - 110639

Published: March 1, 2025

Language: Английский

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Mcl-1 is an important target protein for kaempferol from persimmon leaves in sensitizing ABT-199 to induce apoptosis in hepatoma cancer cells

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(5)

Published: April 1, 2025

Language: Английский

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