CARD16 restores tumorigenesis and restraints apoptosis in glioma cells Via FOXO1/TRAIL axis DOI Creative Commons

Ruoheng Xuan,

Tianyu Hu,

Lingshan Cai

et al.

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(11)

Published: Nov. 8, 2024

A hallmark of glioma cells, particularly glioblastoma multiforme (GBM) is their resistance to apoptosis. Accumulating evidences has demonstrated that CARD16, a caspase recruitment domain (CARD) only protein, enhances both anti-apoptotic and tumorigenic properties. Nevertheless, there limited understanding the expression functional role CARD16 in glioma. This study seeks investigate, through silico analysis clinical specimens, as potential tumor promoter Functional assays molecular studies revealed promotes tumorigenesis suppresses apoptosis cells. Moreover, knockdown FOXO1/TRAIL axis GBM Additionally, FOXO1 downregulation cells restores proliferation reduces Further investigation elevated P21 inhibits CDK2-mediated phosphorylation ubiquitination CARD16-knockdown Collectively, these findings suggest tumor-promoting via downregulating axis, suppressing TRAIL-induced The gene presents significant for prognostic prediction advances innovative apoptotic therapeutics.

Language: Английский

Regulation of ferroptosis by PI3K/Akt signaling pathway: a promising therapeutic axis in cancer DOI Creative Commons
Hua Su, Chao Peng, Yang Liu

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: March 18, 2024

The global challenge posed by cancer, marked rising incidence and mortality rates, underscores the urgency for innovative therapeutic approaches. PI3K/Akt signaling pathway, frequently amplified in various cancers, is central regulating essential cellular processes. Its dysregulation, often stemming from genetic mutations, significantly contributes to cancer initiation, progression, resistance therapy. Concurrently, ferroptosis, a recently discovered form of regulated cell death characterized iron-dependent processes lipid reactive oxygen species buildup, holds implications diseases, including cancer. Exploring interplay between dysregulated pathway ferroptosis unveils potential insights into molecular mechanisms driving or inhibiting ferroptotic cells. Evidence suggests that may sensitize cells induction, offering promising strategy overcome drug resistance. This review aims provide comprehensive exploration this interplay, shedding light on disrupting enhance as an alternative route inducing improving treatment outcomes.

Language: Английский

Citations

21
Unlocking novel therapeutic avenues in glioblastoma: Harnessing 4-amino cyanine and miRNA synergy for next-gen treatment convergence DOI

K Sandhanam,

Tamilanban Thamaraikani,

K. Manasa

et al.

Neuroscience, Journal Year: 2024, Volume and Issue: 553, P. 1 - 18

Published: June 27, 2024

Language: Английский

Citations

5
Mimicry-based strategy between human and commensal antigens for the development of a new family of immune therapies for cancer DOI Creative Commons

Alice Talpin,

Ana Maia,

Jean-Marie Carpier

et al.

Journal for ImmunoTherapy of Cancer, Journal Year: 2025, Volume and Issue: 13(2), P. e010192 - e010192

Published: Feb. 1, 2025

Molecular mimicry between commensal bacterial antigens and tumor-associated (TAAs) has shown potential in enhancing antitumor immune responses. This study leveraged this concept using antigens, termed OncoMimics, to induce TAA-derived peptide (TAAp)-specific cross-reactive cytotoxic T cells improve the efficacy of peptide-based immunotherapies. The discovery OncoMimics primarily relied on a bioinformatics approach identify bacteria-derived sequences mimicking TAAps. Several (OMP) candidates were selected silico based multiple key parameters assess their elicit ameliorate responses against TAAs. Selected OMPs synthesized tested for affinity stability major histocompatibility complex (MHC) vitro capacity OMP-specific/TAAp-specific CD8+T cell human leukocyte antigen (HLA)-A2-humanized mice, peripheral blood mononuclear (PBMC) patients with cancer. demonstrated superior HLA-A2 binding affinities stabilities compared homologous Vaccination HLA-A2-humanized mice led expansion OMP-specific that recognize both TAAps, exhibiting capacities towards tumor resulting protection prophylactic setting. Using PBMCs from HLA-A2+healthy donors, we confirmed ability potent CD8+ T-cell Interestingly, observed high prevalence across donors. Cytotoxicity assays revealed OMP-stimulated specifically targeted killed loaded or Preliminary data an ongoing clinical trial (NCT04116658) support these findings, indicating robust patients. Initial immunomonitoring sustained over time, maintaining polyfunctional, memory phenotype, which is critical effective activity long-term surveillance. These findings suggest leveraging naturally occurring commensal-derived through could significantly remodel landscape, offering guidance promising strategy cancer

Language: Английский

Citations

0
Overexpression of LSR suppresses glioma proliferation and invasion via regulating FOXO3a DOI
Jinlong Zhu, Tong Wang, Xi Liu

et al.

Journal of Neuro-Oncology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Language: Английский

Citations

0
Network pharmacology and in vitro experiments based strategy to explore the effects of Jujuboside A on the proliferation and migration ability of glioma cells DOI

Q. Lv,

Lin Chen, Du Yuan

et al.

Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 149570 - 149570

Published: March 1, 2025

Language: Английский

Citations

0
Unraveling the noncoding RNA landscape in glioblastoma: from pathogenesis to precision therapeutics DOI

K. Sandhanam,

Tamilanban Thamaraikani

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: 397(12), P. 9475 - 9502

Published: July 15, 2024

Language: Английский

Citations

3
Harnessing the role of aberrant cell signaling pathways in glioblastoma multiforme: a prospect towards the targeted therapy DOI
S. M. Murshid Hasan, Zimam Mahmud,

Mahmud Hossain

et al.

Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)

Published: Oct. 19, 2024

Language: Английский

Citations

3
CHAC1: a master regulator of oxidative stress and ferroptosis in human diseases and cancers DOI Creative Commons

Jiasen Sun,

Hui Ren,

Jiawen Wang

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Oct. 29, 2024

CHAC1, an essential regulator of oxidative stress and ferroptosis, is increasingly recognized for its significant roles in these cellular processes impact on various human diseases cancers. This review aims to provide a comprehensive overview CHAC1's molecular functions, regulatory mechanisms, effects different pathological contexts. Specifically, the study objectives are elucidate biochemical pathways involving explore network, discuss implications disease progression potential therapeutic strategies. As γ-glutamyl cyclotransferase, CHAC1 degrades glutathione, affecting calcium signaling mitochondrial function. Its regulation involves transcription factors like ATF4 ATF3, which control mRNA expression. crucial maintaining redox balance regulating cell death cancer. elevated levels associated with poor prognosis many cancers, indicating as biomarker target. Additionally, influences non-cancerous such neurodegenerative cardiovascular disorders. Therapeutically, targeting could increase cancer sensitivity aiding overcoming resistance standard treatments. compiles current knowledge recent discoveries, emphasizing vital role diagnostic applications.

Language: Английский

Citations

3
Targeting Hepatic Cancer Stem Cells (CSCs) and Related Drug Resistance by Small Interfering RNA (siRNA) DOI

Saade Abdalkareem Jasim,

Omar Dheyauldeen Salahdin,

H. Malathi

et al.

Cell Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 82(4), P. 3031 - 3051

Published: July 26, 2024

Language: Английский

Citations

2
FOXO3a deregulation in uterine smooth muscle tumors DOI Creative Commons
Thaís Gomes de Almeida, Anamaria Ritti Ricci, Laura Gonzalez dos Anjos

et al.

Clinics, Journal Year: 2024, Volume and Issue: 79, P. 100350 - 100350

Published: Jan. 1, 2024

The present study aimed to investigate FOXO3a deregulation in Uterine Smooth Muscle Tumors (USMT) and its potential association with cancer development prognosis. authors analyzed gene protein expression profiles of 56 uterine Leiomyosarcomas (LMS), 119 leiomyomas (comprising conventional unusual leiomyomas), 20 Myometrium (MM) samples. used techniques such as Immunohistochemistry (IHC), FISH/CISH, qRT-PCR for the analyses. Additionally, conducted an in-silico analysis understand interaction network involving correlated genes. This investigation revealed distinct patterns protein, including both normal phosphorylated forms. Expression levels were notably elevated LMS, Unusual Leiomyomas (ULM) compared (LM) upregulation was significantly associated metastasis Overall Survival (OS) LMS patients. Intriguingly, did not seem be influenced by EGF/HER-2 signaling, there minimal EGF VEGF detected, HER-2 EGFR negative In examination miRNAs, observed miR-96-5p miR-155-5p, which are known regulators FOXO3a, Conversely, tumor suppressor miR-let7c-5p downregulated. summary, outcomes suggest that imbalance within might arise from phosphorylation miRNA activity. could emerge a promising therapeutic target individuals (ULM LMS), offering novel directions treatment strategies.

Language: Английский

Citations

1