DLAT is involved in ovarian cancer progression by modulating lipid metabolism through the JAK2/STAT5A/SREBP1 signaling pathway
Hui Wang,
No information about this author
Shen Luo,
No information about this author
Yue Yin
No information about this author
et al.
Cancer Cell International,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: Jan. 27, 2025
Language: Английский
Copper homeostasis and copper-induced cell death in tumor immunity: implications for therapeutic strategies in cancer immunotherapy
Sai‐Nan Zhang,
No information about this author
Qibo Huang,
No information about this author
Tuo Ji
No information about this author
et al.
Biomarker Research,
Journal Year:
2024,
Volume and Issue:
12(1)
Published: Oct. 31, 2024
Copper
is
an
important
trace
element
for
maintaining
key
biological
functions
such
as
cellular
respiration,
nerve
conduction,
and
antioxidant
defense.
Maintaining
copper
homeostasis
critical
human
health,
its
imbalance
has
been
linked
to
various
diseases,
especially
cancer.
Cuproptosis,
a
novel
mechanism
of
copper-induced
cell
death,
provides
new
therapeutic
opportunities
metal
ion
regulation
interact
with
fate.
This
review
insights
into
the
complex
mechanisms
metabolism,
molecular
basis
cuproptosis,
association
cancer
development.
We
assess
role
cuproptosis-related
genes
(CRGs)
associated
tumorigenesis,
their
importance
prognostic
indicators
targets,
impact
on
tumor
microenvironment
(TME)
immune
response.
Ultimately,
this
highlights
interplay
between
copper,
immunotherapy.
Language: Английский
Revolutionary multi-omics analysis revealing prognostic signature of thyroid cancer and subsequent in vitro validation of SNAI1 in mediating thyroid cancer progression through EMT
Clinical and Experimental Medicine,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: June 13, 2024
Abstract
Thyroid
carcinoma
(TC),
the
most
commonly
diagnosed
malignancy
of
endocrine
system,
has
witnessed
a
significant
rise
in
incidence
over
past
few
decades.
The
integration
scRNA-seq
with
other
sequencing
approaches
offers
researchers
distinct
perspective
to
explore
mechanisms
underlying
TC
progression.
Therefore,
it
is
crucial
develop
prognostic
model
for
patients
by
utilizing
multi-omics
approach.
We
acquired
and
processed
transcriptomic
data
from
TCGA-THCA
dataset,
including
mRNA
expression
profiles,
lncRNA
miRNA
methylation
chip
data,
gene
mutation
clinical
data.
constructed
tumor-related
risk
using
machine
learning
methods
developed
consensus
learning-driven
signature
(CMLS)
accurate
stable
prediction
patient
outcomes.
2
strains
undifferentiated
cell
lines
1
strain
PTC
line
were
utilized
vitro
validation.
mRNA,
protein
levels
hub
genes,
epithelial-mesenchymal
transition
(EMT)-associated
phenotypes
detected
series
experiments.
identified
3
molecular
subtypes
based
on
integrated
clustering
algorithms,
which
associated
overall
survival
displayed
features.
CMLS
28
genes
predict
outcomes,
demonstrated
that
outperformed
models.
relatively
lower
score
had
significantly
higher
T
cells,
B
macrophages,
indicating
an
immune-activated
state.
Fibroblasts
predominantly
enriched
high
group,
along
markers
immune
suppression
evasion.
several
drugs
could
be
suitable
CMLS,
Staurosporine_1034,
Rapamycin_1084,
gemcitabine,
topotecan.
SNAI1
was
elevated
both
lines,
comparing
cells.
Knockdown
reduced
proliferation
EMT
Our
findings
highlight
importance
analysis
understanding
characteristics
TC,
provide
novel
potential
therapeutic
targets
this
disease.
Moreover,
we
mediating
progression
through
vitro.
Language: Английский
Factors associated with prognosis and staging of intrahepatic cholangiocarcinoma
Journal of Cancer Metastasis and Treatment,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 10, 2024
Intrahepatic
cholangiocarcinoma
(ICC)
is
a
relatively
rare
but
aggressive
primary
liver
cancer
with
poor
prognosis.
A
number
of
established
clinical
and
pathologic
factors
correlate
prognosis,
this
reflected
in
the
American
Joint
Committee
on
Cancer
(AJCC)
8th
Edition
staging
manual.
Researchers
have
identified
areas
for
improvement
prognostication
ICC
using
more
nuanced
tools,
including
serum
biomarkers,
molecular
profiling,
immunophenotyping,
multimodal
prognostic
scoring
systems.
These
data
led
to
proposals
novel
systems
that
attempt
improve
correlation
between
stage
More
accurate
tools
may
aid
treatment
decisions
are
tailored
each
individual
patient,
maximize
therapy
individuals
most
likely
benefit
avoid
unnecessary
toxicity
decision
regret
those
whom
unlikely
alter
outcomes.
Artificial
intelligence
machine
learning
help
researchers
develop
new
models
predict
outcomes
accuracy
precision.
Language: Английский
Targeting cuproptosis for cancer therapy: Focus on the anti-tumor immune system
Cancer Pathogenesis and Therapy,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 1, 2024
Copper
(Cu)
is
an
indispensable
micronutrient
that
maintains
signaling
pathways
and
biological
homeostasis
in
almost
all
cell
types;
however,
its
excess
affects
the
tricarboxylic
acid
cycle,
causes
accumulation
of
fatty
acylated
proteins,
destabilization
iron–sulfur
cluster
increases
levels
intracellular
reactive
oxygen
species,
leading
to
proteotoxic
stress
death.
Cuproptosis,
a
form
Cu-dependent
death,
differs
from
other
types
regulated
death
(RCD)
was
first
reported
Science
2022.
Recently,
RCD
have
been
targeted
cancer
therapy.
However,
escape
apoptosis
tumor
cells
resistance
treatment
recurrence.
Therefore,
there
urgent
need
study
alternative
mechanisms
mortality.
Compared
normal
patients,
significant
increase
serum
Cu
ion
has
observed
patients
with
tumors.
Moreover,
proliferation,
angiogenesis,
metastasis
are
associated
cuproptosis.
Thus,
exploring
related
cuproptosis
will
provide
new
perspective
for
development
anti-cancer
drugs.
Importantly,
closely
modulation
anti-tumor
immunity.
The
expression
cuproptosis-related
genes
(CRGs)
significantly
correlated
immune
infiltration
checkpoint
programmed
protein
1
(PD-1)/programmed
death-ligand
(PD-L1).
Based
on
these
findings,
series
drugs
used
tumor-targeted
combination
therapy
or
as
synergists.
elucidating
role
per
stage
microenvironment
(TIME)
helpful
clarifying
potential
value
specific
cancers.
In
this
review,
we
summarize
based
regulation
concentration.
two
approaches
may
help
researchers
develop
more
therapies
targeting
pathways.
focused
effect
TIME
systematically
discussed
CRGs
immunity
considering
CRG-related
pathways,
prognosis
scoring
system,
immunotherapy,
experiments
bioinformatics
prediction
models,
ideas
anticancer
Language: Английский
The clinicopathological significance and prognostic impact of 14-3-3σ/stratifin expression on patients with surgically resectable intrahepatic cholangiocarcinoma
Su‐Hung Wang,
No information about this author
Yao‐Yu Hsieh,
No information about this author
Khaa Hoo Ong
No information about this author
et al.
Asian Journal of Surgery,
Journal Year:
2024,
Volume and Issue:
48(1), P. 250 - 260
Published: Sept. 3, 2024
Intrahepatic
cholangiocarcinoma
(iCCA)
is
the
second
most
common
primary
liver
cancer
after
hepatocellular
carcinoma.
Through
data
mining
of
publicly
available
iCCA
transcriptomic
datasets
from
Gene
Expression
Omnibus,
we
identified
SFN
as
significantly
up-regulated
gene
in
compared
to
normal
tissue,
focusing
on
Ontology
term
"cell
proliferation"
(GO:0008283).
encodes
14-3-3σ
protein,
also
known
stratifin,
which
plays
crucial
roles
various
cellular
processes.
Immunohistochemistry
was
used
assess
stratifin
expression
182
patients
with
localized
iCCAs
undergoing
surgical
resection.
Patients
were
divided
into
low
and
high
groups,
association
between
clinicopathological
features
analyzed.
Univariate
multivariate
survival
analyses
performed
overall
(OS),
disease-specific
(DSS),
local
recurrence-free
(LRFS),
metastasis-free
(MeFS).
Elevated
associated
absence
hepatitis,
positive
margins,
advanced
tumor
stages,
higher
histological
grades
(all
p
≤
0.011).
Survival
demonstrated
a
significant
negative
all
prognostic
indicators,
including
OS,
DSS,
LRFS,
MeFS
0.0004).
Multivariate
analysis
revealed
that
overexpression
correlated
poorer
outcomes
terms
<
0.001).
These
findings
suggest
may
play
role
oncogenesis
progression,
serving
potential
novel
biomarker.
Language: Английский