Role and clinical value of serum hsa_tsr011468 in lung adenocarcinoma DOI
Ping Zhao,

Kui Zhu,

Cuihua Xie

et al.

Molecular Medicine Reports, Journal Year: 2024, Volume and Issue: 30(6)

Published: Oct. 4, 2024

Transfer RNA‑derived small RNAs (tsRNAs) are novel non‑coding that associated with the pathogenesis of various diseases. However, their association lung adenocarcinoma (LUAD) has not been studied comprehensively. Therefore, present study aimed to explore diagnostic value a tsRNA, hsa_tsr011468, in LUAD. The OncotRF database was used screen tsRNAs and reverse transcription‑quantitative PCR (RT‑qPCR) performed detect expression levels hsa_tsr011468 samples. Subsequently, prognostic values for LUAD were determined via receiver operating characteristic (ROC) curve survival analyses, by assessing clinicopathological parameters. In addition, both nuclear cytoplasmic RNA extracted assess location hsa_tsr011468. identified high results RT‑qPCR showed relative serum tissues patients higher than those normal controls. Furthermore, its lower postoperative samples preoperative from ROC curves indicated had good value. analysis revealed tumor size. mainly localized cytoplasm cells. and, therefore, could be employed as marker

Language: Английский

EGCG Alleviates DSS-Induced Colitis by Inhibiting Ferroptosis Through the Activation of the Nrf2-GPX4 Pathway and Enhancing Iron Metabolism DOI Open Access
Junzhou Chen,

Chibiao Yin,

Yilong Zhang

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 547 - 547

Published: Jan. 31, 2025

Background: Ferroptosis is a regulated cell death process linked to various diseases. This study explored whether Epigallocatechin-3-gallate (EGCG), tea-derived antioxidant, could regulate ferroptosis alleviate dextran sulfate sodium (DSS)-induced colitis. Methods: A DSS-induced colitis model was used assess EGCG’s effects. markers, oxidative stress, and iron metabolism were evaluated, alongside Nrf2-GPX4 pathway activation ferritin (FTH/L) expression. Results: Iron dysregulation stress contributed by activating in colonic epithelial cells. EGCG supplementation inhibited ferroptosis, reducing damage. Mechanistically, activated the pathway, enhancing antioxidant defense, improved upregulating Conclusions: effectively suppressed colitis, highlighting its potential as inhibitor therapeutic agent.

Language: Английский

Citations

1
Research Progress on the tsRNA Biogenesis, Function, and Application in Lung Cancer DOI Creative Commons
Yu Chen, Zhuowei Shao,

Shibo Wu

et al.

Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 10, P. 63 - 69

Published: Sept. 4, 2024

Language: Английский

Citations

6
The Role of tRNA-Derived Small RNAs (tsRNAs) in Regulating Cell Death of Cardiovascular Diseases DOI Creative Commons
Jiaxu Guo, Xinzhe Chen, Jiahao Ren

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(2), P. 218 - 218

Published: Feb. 19, 2025

Transfer RNA is a class of non-coding that plays role in amino acid translocation during protein synthesis. After specific modification, the cleaved fragment called tRNA-derived small RNA. The advancement bioinformatics technology has led to an increase visibility derived from tRNA, and their functions biological processes are being revealed. These include gene silencing, transcription translation, epigenetics, cell death. properties have implication tsRNAs various diseases. Although current research mainly focuses on cancer, there mounting evidence they also strongly associated with cardiovascular disease, including cardiac hypertrophy, atrial fibrillation, heart failure, myocarditis. Therefore, regulatory disease will become emerging therapeutic strategy. This review succinctly summarizes characteristics, classification, effect tsRNA. By exploring mechanism tsRNA, it provide new tool for diagnosis prognosis disease.

Language: Английский

Citations

0
Differences of tsRNA expression profiles efficiently discriminate monozygotic twins in peripheral blood DOI
Meihui Tian,

Xiangnian Liu,

Dan‐Yang Wang

et al.

Forensic Science International Genetics, Journal Year: 2025, Volume and Issue: 77, P. 103242 - 103242

Published: Feb. 21, 2025

Language: Английский

Citations

0
Epigallocatechin Gallate Alleviates Lipopolysaccharide-Induced Intestinal Inflammation in Wenchang Chicken by Inhibiting the TLR4/MyD88/NF-κB Signaling Pathway DOI Creative Commons
Xin Xu, Kunpeng Li, Qian Liu

et al.

Veterinary Sciences, Journal Year: 2025, Volume and Issue: 12(3), P. 225 - 225

Published: March 2, 2025

Intestinal inflammation significantly compromises broiler health and adversely affects growth performance. Epigallocatechin gallate (EGCG) was found to maintain the gut of animals. However, role mechanism EGCG in preventing lipopolysaccharide (LPS)-induced intestinal chicks have not yet been fully elucidated. In 35-day study, 140 one-day-old Wenchang chickens were randomly assigned four treatments: CON (basal diet), LPS diet + 1 mg/kg body weight (BW) LPS), L-EGCG 40 BW H-EGCG 60 LPS). On days 31, 33, 35 age, broilers LPS, L-EGCG, treatments received intraperitoneal injections LPS. The reduced jejunal villus height, height/crypt depth ratio, Claudin1 mRNA, catalase (CAT) activity, interleukin-10 (IL-10) levels compared while elevating diamine oxidase (DAO), interleukin-1β (IL-1β), tumor necrosis factor α (TNF-α). improved performance LPS-challenged broilers, height Claudin1/ZO-1 mRNA with serum DAO. It enhanced antioxidant capacity via increased total (T-AOC), superoxide dismutase (T-SOD), CAT, glutathione peroxidase (GSH-Px) activities, a decreased malondialdehyde (MDA) concentration. Concurrently, lowered IL-1β/TNF-α raised IL-10 serum/jejunum. Crucially, suppressed TLR4/MyD88/NF-κB protein expression under These findings demonstrate EGCG’s protective against LPS-induced through pathway inhibition.

Language: Английский

Citations

0
Emerging Ferroptosis Involvement in Amyotrophic Lateral Sclerosis Pathogenesis: Neuroprotective Activity of Polyphenols DOI Creative Commons

Annamaria Russo,

Stefano Putaggio,

Ester Tellone

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(6), P. 1211 - 1211

Published: March 8, 2025

Neurodegenerative diseases are a group of that share common features, such as the generation misfolded protein deposits and increased oxidative stress. Among them, amyotrophic lateral sclerosis (ALS), whose pathogenesis is still not entirely clear, complex neurodegenerative disease linked both to gene mutations affecting different proteins, superoxide dismutase 1, Tar DNA binding 43, Chromosome 9 open frame 72, Fused in Sarcoma, altered iron homeostasis, mitochondrial dysfunction, stress, impaired glutamate metabolism. The purpose this review highlight molecular targets ALS ferroptosis. Indeed, many pathways implicated hallmarks ferroptosis, recently discovered type iron-dependent programmed cell death characterized by reactive oxygen species (ROS) lipid peroxidation. Iron accumulation results dysfunction levels ROS, peroxidation, ferroptosis triggers; addition, inhibition Xc− system reduced cystine accumulation, leading excitotoxicity GPx4 synthesis. These potential involvement ALS, providing new biochemical could be exploited treatment using polyphenols.

Language: Английский

Citations

0
Comprehensive profiling of tsRNAs in acute coronary syndrome: expression patterns, clinical correlations, and functional insights DOI Creative Commons

Yi He,

Jing Wang, Chen Chen

et al.

Human Genetics, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

Transfer RNA-derived small RNAs (tsRNAs) have emerged as potential biomarkers of various human diseases. However, the clinical utility and biological functions tsRNA in acute coronary syndrome (ACS) remain poorly understood. To investigate this, we performed high-throughput RNA sequencing on peripheral blood monocyte cells (PBMCs) from 24 ACS patients 12 healthy controls. Our analysis revealed distinct characteristic expression patterns tsRNAs response to ACS, highlighting their disease signatures PBMCs. Differentially expressed were validated using RT-qPCR two independent case-control sets. Among these, tRF-Gly-GCC-06 was significantly upregulated volunteers with unstable angina (UA) myocardial infarction (AMI) (p < 0.05) showed a statistically significant positive correlation Gensini score (r = 0.353, p 0.001). Moreover, this independently associated an increased risk after adjusting for conventional cardiovascular factors (odds ratio (OR) 1.58, 95% confidence interval (CI): 1.37-1.83, A series functional studies that facilitated macrophage proliferation migration modulated inflammation-related gene vitro. This study identified novel tRF-Gly-GCC-06, biomarker therapeutic target.

Language: Английский

Citations

0
A novel tRNA-Derived Fragment, tRF-20-M0NK5Y93 inhibits the malignant progression of non-small cell lung cancer by mediating PLOD1 DOI
Lixin Wu, Xiaojie Chen, Chen Dong

et al.

Archives of Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown, P. 110431 - 110431

Published: April 1, 2025

Language: Английский

Citations

0
Health-promoting functions and related comprehensive molecular mechanisms of tea: from the perspectives of anti-inflammatory, lipid-lowering, glucose-lowering and anti-cancer effects DOI
Jingguo Xu, S. M. Jia,

Yuting Ren

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106769 - 106769

Published: May 1, 2025

Language: Английский

Citations

0
Epigallocatechin-3-gallate attenuates fluoride induced apoptosis via PI3K/FoxO1 pathway in ameloblast-like cells DOI Creative Commons
Qian Zhang,

Xiuzhi Fei,

Yue Li

et al.

Toxicon, Journal Year: 2024, Volume and Issue: 247, P. 107857 - 107857

Published: July 10, 2024

Fluoride is a double-edged sword. It was widely used for early caries prevention while excessive intake caused toxicology effect, affected enamel development, and resulted in dental fluorosis. The study aimed to evaluate the protective effect mechanism of Epigallocatechin-3-gallate (EGCG) on apoptosis induced by fluoride ameloblast-like cells. We observed that NaF triggered apoptotic alterations cell morphology, arrested cycle at G1, up-regulating Bax down-regulating Bcl-2. activated insulin-like growth factor receptor (IGFR), phosphatidylinositol-3-hydroxylase (p-PI3K), dose-dependently expression Forkhead box O1 (FoxO1). EGCG supplements reversed changes LS8 cycle, fluoride. These results indicated possesses against toxicity. Furthermore, suppressed activation p-PI3K down-regulation FoxO1 Collectively, our findings suggested attenuated fluoride-induced inhibiting PI3K/FoxO1 signaling pathway. may serve as new alternative method fluorosis prevention, control, treatment.

Language: Английский

Citations

3