A novel cancer-associated lncRNA, LINC01123, participates in tumor progression, metabolism, immune escape, and resistance

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 4, 2025

Long Intergenic Non-Protein Coding RNA 1123 (LINC01123), located on human chromosome 2q13, is a pivotal factor in tumorigenesis, exerting multifaceted oncogenic effects. Its expression strongly correlates with clinicopathological features, patient survival, and disease progression. In vivo vitro experiments further demonstrate that LINC01123 influences diverse cellular processes, including proliferation, apoptosis, viability, migration, invasion, stemness, tumor growth. Notably, it also regulates metabolic reprogramming, immune escape, cell resistance to treatment. regulated by multiple transcription factors participates gene regulation through protein interactions competitive endogenous (ceRNA) networks, thereby modulating cancer-promoting This work systematically elucidates its primary functions molecular mechanisms driving cancer initiation progression, suggesting might serve as novel potential driver biomarker various cancers.

Language: Английский

Correction: ARAP1-AS1: A novel long non-coding RNA with a vital regulatory role in human cancer development

Cancer Cell International, Journal Year: 2024, Volume and Issue: 24(1)

Published: Aug. 16, 2024

Language: Английский