Characteristic, Regulation and Targeting Strategies of Cancer Stem Cells and Their Niche in Digestive System Tumors DOI Creative Commons
Zhenzhen Chen,

Huixiong Qi,

Yapeng Xue

et al.

MedComm – Oncology, Journal Year: 2025, Volume and Issue: 4(2)

Published: April 8, 2025

ABSTRACT Digestive system tumor, including esophageal gastric intestinal liver pancreatic and cholangiocarcinoma, are the most common tumors worldwide serve as a major cause of tumor‐related death. Cancer stem cells (CSCs) small group in that harbor self‐renewal, differentiation abilities, playing crucial role tumor initiation, progression, metastasis, supposed to be fundamental recurrence after conventional treatment. A comprehensive understanding targeting CSCs is key overcoming tumors. In this review, focusing on digestive tumors, we summarize characteristics CSCs, review intracellular mechanisms regulate self‐renewal functional maintenance stemness pathways, transcription epigenetic regulation, metabolic noncoding RNAs, demonstrate microenvironmental regulation systemic at molecular cellular levels. Finally, recent advances therapy with CSC their niche remodeling. These research progress provide insights into occurrence, development, drug resistance, metastasis offers new targeted treatment strategies for defeating

Language: Английский

Recent advances in targeting cancer stem cells by using nanomaterials DOI
Vahid Rahimkhoei, Ali Akbari,

Amar Yasser Jassim

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125381 - 125381

Published: Feb. 1, 2025

Language: Английский

Citations

1
An update on regulation and function of G protein-coupled receptors in cancer: A promising strategy for cancer therapy DOI
Lin Li,

Zihao An,

Chao Lin

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: unknown, P. 189266 - 189266

Published: Jan. 1, 2025

Language: Английский

Citations

0
Innovative Therapeutic Approach Targeting Colon Cancer Stem Cells: Transitional Cold Atmospheric Plasma DOI Creative Commons
Abolfazl Soulat, Taghi Mohsenpour, Leila Roshangar

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: 10(12), P. 12109 - 12121

Published: March 6, 2025

Transitional cold atmospheric plasma (TCAP) represents a novel technique for generating remotely from primary source. It consists of partially nonthermal ionized gas mixture containing charged and neutral particles, photons, free radicals. In recent years, TCAP has attracted considerable attention in biomedical applications. order to evaluate colon cancer stem cells' (CCSCs) proliferation, apoptotic induction, inflammatory response, survival, was utilized both directly indirectly this study. Using argon helium gases, continuously delivered two stages during the experiment. For direct state, irradiated onto CCSCs 3 5 min. indirect technique, Matrigel treated with min before introduction cells. vitro assays demonstrated that exposure significantly reduced viability CCSCs; application had greater impacts than argon. Numerous investigations confirmed induction apoptosis, showing groups more cells altered cellular structures controls (****p < 0.0001). A substantial increase Bax/Bcl-2 ratio found by analyzing expression Bax Bcl-2 genes, indicating increased susceptibility apoptosis (*p = 0.0177 ***p 0.0004). The higher efficacy mode further highlighted marker analysis, which showed significant reduction interleukin-6 interleukin-8 TCAP-helium compared TCAP-argon (**p 0.0015 0.0007). Lastly, proliferation test, relies on Ki-67 expression, noteworthy decline all TCAP-treated groups, group exhibiting most robust impact 0.0014). Overall, findings highlight potential TCAP, particularly helium, as promising approach selectively targeting providing insights into its therapeutic mechanisms treatment. therefore, emerges unique strategy applications cell-targeted therapies.

Language: Английский

Citations

0
Natural Bioactive Agents: Testable Stem Cell-Targeting Alternatives for Therapy-Resistant Breast Cancer DOI Open Access
Nitin Telang

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2529 - 2529

Published: March 12, 2025

Long-term treatment options for conventional chemo-endocrine therapy and molecular-pathway-based targeted are associated with acquired resistance the emergence of drug-resistant cancer-initiating stem cell populations, leading to progression metastatic disease. These based on expression status estrogen receptor-α (ER-α), progesterone receptor (PR) hormone receptors, and/or human epidermal growth factor receptor-2 (HER-2). The breast cancer subtypes Luminal A, B, HER-2-enriched express hormone/growth receptors exhibit a favorable response modulators antagonists. triple-negative subtype lacks responds only cytotoxic chemotherapy. clinical limitations, due modest therapeutic responses chemo-resistant cells, emphasize need identification cells targeting testable alternatives therapy-resistant cancer. Developed models upregulated select cellular biomarker tumor spheroid (TS) formations cluster differentiation44 (CD44), DNA-binding protein (NANOG), octamer-binding protein-4 (OCT-4) molecular biomarkers that represent novel experimentally modifiable quantitative endpoints. Naturally occurring dietary phytochemicals nutritional herbs containing polyphenols, flavones, terpenes, saponins, lignans, tannins have documented consumption, lack systemic toxicity, phenotypic drug resistance, preclinical efficacy. Constituent bioactive agents may provide cell-targeting alternatives. present report provides an overview (i) clinically relevant subtypes, (ii) evidence efficacy mechanistic leads natural herbs, (iii) potential as candidates

Language: Английский

Citations

0
Unveiling the future of cancer stem cell therapy: a narrative exploration of emerging innovations DOI Creative Commons

Joseph Nhyira Obisi,

Abike Ndidiamaka Josephine Abimbola,

Oluwasegun Adesina Babaleye

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 22, 2025

Cancer stem cells (CSCs), are a critical subpopulation within tumours, and defined by their capacity for self-renewal, differentiation, tumour initiation. These unique traits contribute to progression, metastasis, resistance conventional treatments like chemotherapy radiotherapy, often resulting in cancer recurrence poor patient outcomes. As such, CSCs have become focal points developing advanced therapies. This review highlights progress CSC-targeted treatments, including chimeric antigen receptor T-cell (CAR-T) therapy, immunotherapy, molecular targeting, nanoparticle-based drug delivery systems. Plant-derived compounds gene-editing technologies, such as clustered regularly interspaced short palindromic repeats (CRISPR), explored potential enhance precision minimize side effects. Metabolic pathways integral CSC survival, mitochondrial dynamics, mitophagy (regulated dynamin-related protein 1 [DRP1] the PINK1/Parkin pathway), one-carbon metabolism, amino acid metabolism (involving enzymes glutaminase (GLS) glutamate dehydrogenase (GDH]), lipid hypoxia-induced metabolic reprogramming mediated hypoxia-inducible factors (HIF-1α HIF-2α), examined therapeutic targets. The adaptability of through autophagy, flexibility, epigenetic regulation metabolites α-ketoglutarate, succinate, fumarate is discussed. Additionally, extracellular vesicles nicotinamide adenine dinucleotide (NAD⁺) identified pivotal redox balance, DNA repair, modifications. Addressing challenges heterogeneity, immune evasion, treatment durability requires interdisciplinary collaboration. Advancing therapies essential overcoming preventing relapse, paving way transformative treatments. underscores importance leveraging innovative technologies fostering collaboration revolutionize treatment.

Language: Английский

Citations

0
Characteristic, Regulation and Targeting Strategies of Cancer Stem Cells and Their Niche in Digestive System Tumors DOI Creative Commons
Zhenzhen Chen,

Huixiong Qi,

Yapeng Xue

et al.

MedComm – Oncology, Journal Year: 2025, Volume and Issue: 4(2)

Published: April 8, 2025

ABSTRACT Digestive system tumor, including esophageal gastric intestinal liver pancreatic and cholangiocarcinoma, are the most common tumors worldwide serve as a major cause of tumor‐related death. Cancer stem cells (CSCs) small group in that harbor self‐renewal, differentiation abilities, playing crucial role tumor initiation, progression, metastasis, supposed to be fundamental recurrence after conventional treatment. A comprehensive understanding targeting CSCs is key overcoming tumors. In this review, focusing on digestive tumors, we summarize characteristics CSCs, review intracellular mechanisms regulate self‐renewal functional maintenance stemness pathways, transcription epigenetic regulation, metabolic noncoding RNAs, demonstrate microenvironmental regulation systemic at molecular cellular levels. Finally, recent advances therapy with CSC their niche remodeling. These research progress provide insights into occurrence, development, drug resistance, metastasis offers new targeted treatment strategies for defeating

Language: Английский

Citations

0