A review of molecular interplay between inflammation and cancer: The role of lncRNAs in pathogenesis and therapeutic potential DOI

Yan Yang,

Chuxi Zhang,

H C Li

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142824 - 142824

Published: April 1, 2025

Language: Английский

The Clinopathological and Prognostic Significance of SPOCK1 in Gynecological Cancers: A Bioinformatics Based Analysis DOI Creative Commons
Enes Karaman, Fatih Yay, Durmuş Ayan

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(2), P. 209 - 209

Published: Feb. 16, 2025

Background: Sparc/osteonectin, cwcv, and kazal-like domains proteoglycan 1 (SPOCK1) is an oncogene that promotes tumor formation progression in certain types of cancer associated with poor survival rates. However, there limited information on the importance SPOCK1 gynecological cancers literature. The aim this study was to explore role ovarian serous cystadenocarcinoma (OV), cervical squamous cell carcinoma endocervical adenocarcinoma (CESC), uterine corpus endometrial carcinomas (UCEC). Methods: data used were obtained from GEPIA2, TCGA, Kaplan-Meier Plotter, GeneMANIA, UALCAN, cBioPortal, TIMER databases. Overall (OS) relapse-free (RFS) rates evaluated by analysis. Spearman's rho statistical significance values for correlation between expression infiltration different immune cells. Results: Lower gene observed CESC UCEC compared normal tissue (p < 0.05), but OV did not differ significantly > 0.05). In OV, solely linked age; CESC, it age, stage, weight, histology; UCEC, menopausal status. Conclusions:SPOCK1 showed weak positive correlations CD8+ T cells negative CD4+ may be a potential prognostic therapeutic target cancers.

Language: Английский

Citations

0
Relationship between expression of lncRNA HOTAIR and miR-302b-3p and circulating tumor cells in colon cancer and their value for prognostic prediction DOI Open Access
Ling Wang, Xia Lin,

Guo-Yong Qi

et al.

Shijie huaren xiaohua zazhi, Journal Year: 2025, Volume and Issue: 33(2), P. 140 - 147

Published: Feb. 28, 2025

Language: Английский

Citations

0
LncRNAs Ride the Storm of Epigenetic Marks DOI Open Access
Giulia Gaggi,

Clinton Hausman,

Soomin Cho

et al.

Genes, Journal Year: 2025, Volume and Issue: 16(3), P. 313 - 313

Published: March 6, 2025

Advancements in genome sequencing technologies have uncovered the multifaceted roles of long non-coding RNAs (lncRNAs) human cells. Recent discoveries identified lncRNAs as major players gene regulatory pathways, highlighting their pivotal role cell growth and development. Their dysregulation is implicated onset genetic disorders age-related diseases, including cancer. Specifically, they been found to orchestrate molecular mechanisms impacting epigenetics, DNA methylation hydroxymethylation, histone modifications, chromatin remodeling, thereby significantly influencing expression. This review provides an overview current knowledge on lncRNA-mediated epigenetic regulation expression, emphasizing biomedical implications development different types cancers diseases.

Language: Английский

Citations

0
A review of molecular interplay between inflammation and cancer: The role of lncRNAs in pathogenesis and therapeutic potential DOI

Yan Yang,

Chuxi Zhang,

H C Li

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142824 - 142824

Published: April 1, 2025

Language: Английский

Citations

0