Tumor-Educated Platelets in Urological Tumors: A Novel Biosource in Liquid Biopsy DOI Open Access
Mariona Figols,

Sviatoslav Chekhun,

Maria Fernández-Saorin

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3595 - 3595

Published: April 11, 2025

Platelets, traditionally recognized for their role in hemostasis, have emerged as pivotal players cancer biology. They actively contribute to tumor proliferation, angiogenesis, immune evasion, and metastasis thus play a significant progression. Tumor-educated platelets (TEPs) acquire protumorigenic phenotypes through RNA, protein, receptor profile alterations driven by interactions with tumors microenvironment. These modifications enable TEPs enhance growth dissemination critical throughout the metastatic process. Moreover, are promising biomarkers that can easily be analyzed liquid biopsies. Since they dynamically mirror activity transcriptomic proteomic changes, analysis offers non-invasive method determining detection diagnosis, patient prognosis, therapy monitoring, personalization of treatment. Their demonstrated accuracy identifying types predicting treatment responses underscores ability provide real-time insights into biology, including urological malignancies. diagnostic potential accessibility blood-sourced position transformative tools advancing personalized oncology. Here, we focus on tumors, exploring applications early detection, disease design tailored therapeutic strategies.

Language: Английский

Tumor-Educated Platelets in Urological Tumors: A Novel Biosource in Liquid Biopsy DOI Open Access
Mariona Figols,

Sviatoslav Chekhun,

Maria Fernández-Saorin

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3595 - 3595

Published: April 11, 2025

Platelets, traditionally recognized for their role in hemostasis, have emerged as pivotal players cancer biology. They actively contribute to tumor proliferation, angiogenesis, immune evasion, and metastasis thus play a significant progression. Tumor-educated platelets (TEPs) acquire protumorigenic phenotypes through RNA, protein, receptor profile alterations driven by interactions with tumors microenvironment. These modifications enable TEPs enhance growth dissemination critical throughout the metastatic process. Moreover, are promising biomarkers that can easily be analyzed liquid biopsies. Since they dynamically mirror activity transcriptomic proteomic changes, analysis offers non-invasive method determining detection diagnosis, patient prognosis, therapy monitoring, personalization of treatment. Their demonstrated accuracy identifying types predicting treatment responses underscores ability provide real-time insights into biology, including urological malignancies. diagnostic potential accessibility blood-sourced position transformative tools advancing personalized oncology. Here, we focus on tumors, exploring applications early detection, disease design tailored therapeutic strategies.

Language: Английский

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