Post introduction evaluation of the malaria vaccine implementation programme in Ghana, 2021

BMC Public Health, Journal Year: 2023, Volume and Issue: 23(1)

Published: March 29, 2023

Malaria remains a public health challenge in Sub-Saharan Africa with the region contributing to more than 90% of global cases 2020. In Ghana, malaria vaccine was piloted assess feasibility, safety, and its impact context routine use alongside existing recommended control measures. To obtain context-specific evidence that could inform future strategies introducing new vaccines, standardized post-introduction evaluation (PIE) successes challenges implementation programme (MVIP) conducted.From September December 2021, WHO Post-Introduction Evaluation tool used conduct mixed methods MVIP Ghana. ensure representativeness, study sites participants from national level, 18 vaccinating districts, 54 facilities six seven pilot regions were purposively selected. Quantitative qualitative data collected using collection tools adapted based on PIE protocol. We performed summary descriptive statistics quantitative data, thematic analysis triangulation results both sets analyses.About 90.7% (49/54) workers stated introduction process smooth contributed an overall improvement immunisation services. About 87.5% (47/54) healthcare workers, 95.8% (90/94) caregivers accepted RTS,S vaccine. Less half [46.3%; (25/54)] participated pre-vaccine training but almost all [94.4%; (51/54)] able constitute administer appropriately. 92.5% (87/94) aware only 44.0% (44/94) knew number doses needed for maximum protection. Health believed has had positive under five morbidity.The been successfully Intensive advocacy; community engagement, social mobilization; regular onsite supportive supervision are critical enablers successful vaccines. Stakeholders convinced feasibility nationwide scale up phased subnational approach taking into consideration epidemiology availability

Language: Английский

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Policy uptake and implementation of the RTS,S/AS01 malaria vaccine in sub-Saharan African countries: status 2 years following the WHO recommendation

BMJ Global Health, Journal Year: 2024, Volume and Issue: 9(4), P. e014719 - e014719

Published: April 1, 2024

In October 2021, the WHO recommended world’s first malaria vaccine—RTS,S/AS01—to prevent in children living areas with moderate-to-high transmission sub-Saharan Africa (SSA). A second vaccine, R21/Matrix-M, was for use 2023 and added to list of prequalified vaccines December 2023. This study analysis assessed country status implementation delivery strategies RTS,S/AS01 by searching websites national policies, guidelines related documents. Direct contact individuals working programmes made obtain documents not publicly available. 10 countries had information relating vaccine implementation, 7 referencing 3 (Burkina Faso, Kenya Nigeria) R21/Matrix-M. Five other reported plans roll-out without specifying which vaccine. Ghana, Malawi, piloted RTS,S/AS01, have now integrated into routine immunisation services. Cameroon Burkina Faso are outside pilot incorporate Uganda a phased introduction, while Guinea five districts. The schedule varied country, dose administered at 5 or 6 months all but fourth either 18, 22 24 months. SSA shown widespread interest rolling out Global Alliance Vaccines Immunization having approved financial support 20 30 applied as March 2024. Limited availability means that some will receive required doses. Vaccine equity must be addressed even R21/Matrix-M becomes

Language: Английский

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Willingness to accept malaria vaccines amongst women presenting at outpatient and immunization clinics in Enugu state, Southeast Nigeria

Malaria Journal, Journal Year: 2024, Volume and Issue: 23(1)

Published: April 25, 2024

There are giant steps taken in the introduction of novel malaria vaccine poised towards reducing mortality and morbidity associated with malaria.

Language: Английский

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Malaria vaccine efficacy, safety, and community perception in Africa: a scoping review of recent empirical studies

Infection, Journal Year: 2024, Volume and Issue: 52(5), P. 2007 - 2028

Published: March 5, 2024

The review summarizes the recent empirical evidence on efficacy, safety, and community perception of malaria vaccines in Africa.

Language: Английский

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Integration of the RTS,S/AS01 malaria vaccine into the Essential Programme on Immunisation in western Kenya: a qualitative longitudinal study from the health system perspective

The Lancet Global Health, Journal Year: 2024, Volume and Issue: 12(4), P. e672 - e684

Published: Feb. 28, 2024

Language: Английский

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RTS,S/AS01E vaccine defaults in Ghana: a qualitative exploration of the perspectives of defaulters and frontline health service providers

Malaria Journal, Journal Year: 2023, Volume and Issue: 22(1)

Published: Sept. 6, 2023

While Ghana has a good track record in the Expanded Programme on Immunization, there are substantial challenges with regards to subsequent vaccinations, particularly after first year of life child. Given that last dose RTS, S/AS01

Language: Английский

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RTS,S/AS01 malaria vaccine pilot implementation in western Kenya: a qualitative longitudinal study to understand immunisation barriers and optimise uptake

BMC Public Health, Journal Year: 2023, Volume and Issue: 23(1)

Published: Nov. 18, 2023

Malaria is a significant public health threat in sub-Saharan Africa, particularly among children. The RTS,S/AS01 malaria vaccine reduces the risk and severity of was piloted three African countries, Ghana, Kenya Malawi, to assess safety, feasibility cost-effectiveness real-world settings. A qualitative longitudinal study conducted as part assessment. This analysis explores vaccination barriers identifies potential motivators caregivers sub-counties western Kenya.

Language: Английский

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Bridging the gap to malaria vaccination in Africa: Challenges and opportunities

Journal of Medicine Surgery and Public Health, Journal Year: 2024, Volume and Issue: 2, P. 100059 - 100059

Published: Jan. 26, 2024

The current state of malaria is devastating owing to the continual dominance P. falciparum in African region. Despite progress, burden remains high, with continent contributing significantly global deaths. introduction vaccines, such as RTS,S/AS01 and R21/Matrix-M™, brings hope continent, but challenges persist achieving widespread coverage. Financial constraints, fragmented supply chains, logistical challenges, vaccine hesitancy are key obstacles. complex interplay social, cultural, biological, political, educational factors further complicates fight against malaria. To bridge vaccination gap, a multifaceted approach involving healthcare facilities, governments, non-profit organisations, agencies expedient. It emphasises importance community engagement, collaboration cultural religious leaders, leveraging mass media for awareness campaigns tailored diverse cultures. Specific recommendations include improving infrastructure, enhancing access qualified providers, creating effective transportation management systems, implementing comprehensive inventory policies. Governments urged prioritise multistakeholder collaboration, strengthen technical working groups, expedite bureaucratic processes, invest multidisciplinary research identify address obstacles vaccination. calls cooperative efforts, better data utilisation, improved diagnostics, interventions reduce prevalence improve public health Africa. By emphasising significance education, knowledge, targeted campaigns, strategic communication rollout, we can gaps

Language: Английский

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Factors associated with vaccine default in Southern Ghana based on data from the RTSS malaria vaccine trial in Cape Coast

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 2, 2025

Language: Английский

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Navigating the Road to Immunization Equity: Systematic Review of Challenges in Introducing New Vaccines into Sub-Saharan Africa’s Health Systems

Vaccines, Journal Year: 2025, Volume and Issue: 13(3), P. 269 - 269

Published: March 4, 2025

Background/Objectives: Over the past 50 years, developing new vaccines has been pivotal in responding to emerging and re-emerging diseases globally. However, despite substantial partner support, introducing sub-Saharan Africa remains challenging. This systematic review documents barriers vaccine introduction by distinguishing between integrated into routine immunization programs those introduced primarily for outbreak response. Methods: A comprehensive electronic search was conducted across five databases articles published English or French on challenges of Africa. Three reviewers screened independently based titles abstracts, with full-text assessments inclusion. Data were analyzed thematically synthesized narratively. Results: total 796 retrieved from databases. Following screening, 33 finally retained included review. These concerned eight (malaria vaccine, COVID-19 HPV Ebola cholera hepatitis B rotavirus typhoid vaccine). The analyses revealed coordination financing six seventeen countries, acceptability ten logistical two quality service delivery three thirteen countries. Conclusions: Addressing requires targeted, evidence-based strategies. Prioritizing political commitment, innovative funding, public education, workforce development, infrastructure improvements will strengthen systems enable timely delivery. Collaborative efforts a focus local context can advance equitable health outcomes, safeguard health, support global goals.

Language: Английский

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