Published: Oct. 19, 2024
Language: Английский
Malaria Journal, Journal Year: 2025, Volume and Issue: 24(1)
Published: March 18, 2025
Since 2017, the first-line treatment for uncomplicated Plasmodium falciparum infection in Ethiopia has been artemether-lumefantrine (AL), plus a single dose of primaquine (PQ). The World Health Organization (WHO) recommends regular monitoring drug efficacy as crucial tool supporting national policies. This study aimed to assess AL with PQ P. malaria. A prospective single-arm was conducted among outpatients at Shecha Centre, aged six months and older confirmed malaria from October 2023 January 2024. Participants were treated followed up 28 days evaluate clinical parasitological responses. Kaplan–Meier (KM) survival analysis per protocol (PP) used estimate primary secondary outcomes. Paired sample t-test compare mean haemoglobin levels across follow-up dates (SPSS v.25). All comparisons made 95% confidence interval (CI), level significance 0.05. total 93 patients enrolled 88 participants completed study. Based on KM overall PCR uncorrected cure rate 96.6% (95% CI 90.4–99.3%). PCR-corrected 100% 95.8–100%). Despite high rate, accompanied by fast resolution symptoms, 17% continued have detectable parasitaemia day 3. There slight decrease compared baseline. No serious adverse events reported during 28-day period. findings reaffirm malaria, acceptable safety profile. These support ongoing use option infections area. In context emergence spread partial artemisinin-based combination therapy(ACT) resistance Africa, current combinations is recommended early detection emerging setting beyond.
Language: Английский
Citations
0
Malaria Journal, Journal Year: 2024, Volume and Issue: 23(1)
Published: June 12, 2024
Malaria remains a major global health problem although there was remarkable achievement between 2000 and 2015. drug resistance, along with several other factors, presents significant challenge to malaria control elimination efforts. Numerous countries in sub-Saharan Africa have documented the presence of confirmed or potential markers partial resistance against artemisinin, choice for treatment uncomplicated Plasmodium falciparum malaria. The World Health Organization (WHO) recommends regular surveillance artemisinin therapeutic efficacy inform policy decisions.
Language: Английский
Citations
2
Malaria Journal, Journal Year: 2024, Volume and Issue: 23(1)
Published: Aug. 29, 2024
Rapid diagnostic tests (RDTs) provide quick, easy, and convenient early diagnosis of malaria ensuring better case management particularly in resource-constrained settings. Nevertheless, the efficiency HRP2-based RDT can be compromised by Plasmodium falciparum histidine-rich protein 2/3 gene deletion genetic diversity. This study explored diversity PfHRP2/3 uncomplicated cases from Ethiopia. A cross-sectional was conducted June 2022 to March 2023 at Metehara, Zenzelema Kolla Shele health centres, Finger-prick blood samples were collected for testing microscopic examination. For molecular analysis, parasite genomic DNA extracted venous blood. confirmed using VarATS real time PCR. Additionally, amplified, amplicons sequenced Oxford Nanopore technology. sequences revealed small variations frequency number amino acid repeat types per isolate across three centres. Twelve eight repeats identified PfHRP2 PfHRP3, respectively, which had been previously characterized. Repeat type 1, 4 7 present both PfHRP3 sequences. Type 2 commonly dispersed PfHRP2, while 16 17 found only PfHRP3. novel V variant, has never reported Ethiopia, six The majority isolates, as determined Baker's logistic regression model, belonged group C, 86% them sensitive PfHRP2-based RDT. Likewise, detected 100% isolates (product × ≥ 100) 85.7% B 50–99) a parasitaemia level > 250 parasite/μl. highlights significant observed among clinical emphasizes necessity monitoring PfHRP2- based efficacy their distribution large sample size various ecological
Language: Английский
Citations
1
Journal of Parasitology Research, Journal Year: 2024, Volume and Issue: 2024, P. 1 - 7
Published: May 14, 2024
Malaria is one of the major public health problems in sub-Saharan Africa, including Ethiopia. Children under age five are immunologically naive to plasmodium parasites, making them most vulnerable group clinical manifestations malaria infection. Despite severity disease children years age, studies on focus adult population. In present study, a cross-sectional study design based facilities was used during minor season from February 18 May 28, 2023, at Mohammed Akile Memorial General Hospital, Afar Regional State, district Amibara located town Berta. The finding revealed that 19.8% prevalence among symptomatic with 61.04% and 38.96%
Language: Английский
Citations
0
Malaria Journal, Journal Year: 2024, Volume and Issue: 23(1)
Published: Oct. 8, 2024
Plasmodium vivax is the second most common malaria parasite in Ethiopia. It has been treated with chloroquine (CQ) for past seven decades. However, emergence of CQ-resistant strains nation urged Federal Ministry Health Ethiopia to review its national treatment guideline 2018. In revised guideline, first-line uncomplicated P. infection a combination CQ and primaquine (PQ). Thus, present study was designed evaluate vivo efficacy PQ therapy against clinical mono-infection one malaria-endemic areas
Language: Английский
Citations
0
Malaria Journal, Journal Year: 2024, Volume and Issue: 23(1)
Published: Dec. 23, 2024
Ethiopia has been progressing very well in controlling malaria the past few years. However, shortly after COVID-19 pandemic, an unpredictable resurgence was observed almost all malaria-endemic areas of country, although exact cause which not yet identified. Therefore, this study aimed to investigate burden and associated risk factors one endemic zones Ethiopia. A health facility-based retrospective cross-sectional design conducted Kaffa zone, southwest Hence, a seven-year data on positivity rate, interventional activities undertaken area, climatic variables were collected from patient's medical records, district bureau, meteorological institute, respectively. For study, malaria-suspected patients seeking medication at facilities Zone administrative centre, Bonga town, during period (January–June 2024), recruited study. Data socio-demographic, socio-economic, behavioural, environmental using structured face-to-face interview questionnaire. analysed Statistical Package for Social Science software (SPSS) (version 26) statistical tools used descriptive statistics logistic regression models. significant level considered p < 0.05. The findings revealed increment trend (39.43%, n = 188,201/477,276, 0.0001) between July 2018 June 2024. Also, rate documented 50.72% (n 315/621). Plasmodium falciparum dominant parasite. identified weakened control measures (p 0.006), limited awareness population 001), socio-demographic such as education 0.037), age 0.008), housing condition 0.0001), low-income travel history 0.001)] with high rate. In addition, indoor residual spraying (IRS) mean maximum temperature activity increased by 1 unit, decreased 28 times 1.3 0.003), months September strongly positively higher area 0.05). Even though able achieve remarkable reduction years, recent interrupted activities, seasonal variability, patient facility-associated have contributed current Southwest This urges need immediate community sensitization enhance malaria, besides designing integrated vector strategies tackle alarming situation zone.
Language: Английский
Citations
0
Published: Oct. 19, 2024
Language: Английский
Citations
0