Association Between Consumption of Foods Containing Vitamin D and All-Cause Mortality in Korea DOI
Jung Hyun Kwak, Jean Kyung Paik

Journal of Medicinal Food, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 25, 2024

Sufficient vitamin D levels are reported to be a factor in reducing various chronic diseases and resulting mortality rates. Well-dried mushrooms blue-backed fish known rich D. In this study, the association between rates intake of D-rich foods was confirmed using data from Korean Genome Epidemiological Study (KoGES). Among KoGES database, we followed up total 6844 adults who participated Ansung-Ansan cohort study recruited 2001 2002 continued for an average 16.7 years until 2018. The main findings were analyzed Cox regression analysis. During follow-up, 439 cases all-cause mortality, 149 cancer-related 91 cardiovascular confirmed. fully adjusted model, hazard ratio (HR) quartile 3 mushroom consumption 0.709 (95% confidence interval [CI], 0.525-0.958) compared with 1. addition, HRs 0.348 CI, 0.154-0.787) those quartiles 4 0.442 0.226-0.865) 0.533 0.285-0.998), respectively, conclusion, moderate related decreased risk while heightened inversely mortality.

Language: Английский

Vitamin D: Evidence-Based Health Benefits and Recommendations for Population Guidelines DOI Open Access
William B. Grant, Sunil J. Wimalawansa, Paweł Płudowski

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 277 - 277

Published: Jan. 14, 2025

Vitamin D offers numerous under-recognized health benefits beyond its well-known role in musculoskeletal health. It is vital for extra-renal tissues, prenatal health, brain function, immunity, pregnancy, cancer prevention, and cardiovascular Existing guidelines issued by governmental organizations are bone-centric largely overlook the abovementioned extra-skeletal optimal thresholds vitamin D. In addition, they rely on randomized controlled trials (RCTs), which seldom show due to high baseline 25-hydroxyvitamin [25(OH)D] concentrations, moderate supplementation doses, flawed study designs. This review emphasizes findings from prospective cohort studies showing that higher 25(OH)D concentrations reduce risks of major diseases mortality, including pregnancy birth outcomes. Serum > 30 ng/mL (75 nmol/L) significantly lower disease mortality compared <20 ng/mL. With 25% U.S. population 60% Central Europeans having levels ng/mL, should be raised above achievable through daily with 2000 IU/day (50 mcg/day) D3, prevent deaths. Furthermore, a dose between 4000 6000 IU D3 achieve serum 40 70 would provide greater protection against many adverse Future recommendations integrate observational well-designed RCTs improve public personalized care.

Language: Английский

Citations

11
Enhancing the Design of Nutrient Clinical Trials for Disease Prevention—A Focus on Vitamin D: A Systematic Review DOI
Sunil J. Wimalawansa

Nutrition Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

This systematic review (SR) highlights principles for nutrient clinical trials and explore the diverse physiological functions of vitamin D beyond its traditional role in musculoskeletal system related to study designs. Thousands published research articles have investigated benefits (a example taken this SR) system, including immune, pulmonary, cardiovascular systems; pregnancy; autoimmune disorders; cancer. They illustrated D's molecular mechanisms, interactions, genomic nongenomic actions. SR was designed identify shortcomings designs, statistical methods, data interpretation that led inconsistent findings D-related publications. also examples insights into avoiding design errors future studies, randomized controlled (RCTs). The adheres latest PRISMA statement, guidelines, PICOS process. Inappropriate or flawed designs were frequent trials. Major failures discussed here include too short duration, inadequate infrequent doses, insufficient power, failure measure baseline achieved levels, recruiting D-sufficient participants. These misleading interpretations. Thus, conclusions from such studies should not be generalized used recommendations, policymaking. Adequately powered epidemiological RCTs with sufficient duration individuals deficiency reported favorable outcomes, enriching literature, enabling understand physiology mechanisms. Proper rigorous methodologies cautious outcomes are crucial advancing field. apply only D, but other micro-nutrients nutraceutical research. Adhering them enhances credibility reliability trials, SRs, meta-analysis outcomes. emphasizes importance focused, hypothesis-driven, well-designed, statistically nutrients, conducted index deficient participants, avoidance errors. Findings incorporated practice, policymaking, public health improving nation reducing healthcare costs.

Language: Английский

Citations

2
Exploring Vitamin D Synthesis and Function in Cardiovascular Health: A Narrative Review DOI Creative Commons
Gilda Aiello, Mauro Lombardo, Sara Baldelli

et al.

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(11), P. 4339 - 4339

Published: May 21, 2024

Vitamin D plays a crucial role in the human body, influencing wide range of physiological processes from bone health to immune function. The complex biochemical pathways involved synthesis, metabolism, and action are explored, emphasizing its importance nutrition food technology. This review also investigates regulatory mechanisms that control metabolism systemic effects on calcium homeostasis, cell proliferation, differentiation, modulation. D3 regulating blood pressure atherosclerosis onset cardiovascular disorders is discussed. Given science technology, homeostasis investigated, integrating innovative approaches advanced technologies improve through nutrition. Additionally, assesses influence processing levels discusses cutting-edge as strategies mitigate loss during processing. comprehensive exploration aims our understanding relevance science, contributing development new for fortification promotion optimal diet.

Language: Английский

Citations

6
Associations of the serum 25-hydroxyvitamin D with mortality among patients in osteopenia or osteoporosis DOI
Ming Ma,

Yuji Zhang,

Jinmin Liu

et al.

Bone, Journal Year: 2025, Volume and Issue: 193, P. 117408 - 117408

Published: Jan. 23, 2025

Language: Английский

Citations

0
Teaching gender medicine can enhance the quality of healthcare DOI Creative Commons
Anna Vittoria Mattioli, Valentina Bucciarelli, Sabina Gallina

et al.

American Heart Journal Plus Cardiology Research and Practice, Journal Year: 2024, Volume and Issue: 44, P. 100418 - 100418

Published: June 25, 2024

Teaching gender and sex differences is fundamental in medical classes because it has a strong impact reducing disparity treatment, defining effective personalized therapies that respect the different physiology pathophysiology of women. Furthermore, prerequisite for pharmacoequity.

Language: Английский

Citations

1
The Impact of Neutrophil-to-High-Density Lipoprotein Ratio and Serum 25-Hydroxyvitamin D on Ischemic Heart Disease DOI Open Access
Ewelina A. Dziedzic, Jakub S. Gąsior,

Kamila Koseska

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(21), P. 6597 - 6597

Published: Nov. 2, 2024

Background: This study describes the complex association between neutrophil-to-high-density lipoprotein cholesterol ratio (NHR), 25-hydroxyvitamin D (25(OH)D) levels, and cardiovascular disease (CVD), such as stable ischemic heart (IHD), ST elevation myocardial infarction (STEMI), non–ST-segment (NSTEMI), unstable angina (UA). Methods: The serum 25(OH)D concentration NHR values were analyzed in groups of patients with chronic coronary syndrome (CCS) acute (ACS). severity artery atherosclerosis was determined using Coronary Artery Surgery Study (CASS) scale. Results: Significant differences concentrations observed CCS (ACS)/STEMI (p < 0.01). Higher associated diagnosis CCS, higher ACS/STEMI. threshold for ACS set at 0.10 0.001). Patients without significant stenosis showed significantly levels lower Conclusions: correlation 25(OH)D, HDL, suggests that vitamin D, through its influence on inflammatory processes lipid metabolism, may play a role pathogenesis syndromes. suggested bidirectional relationship predictor require further well-designed studies.

Language: Английский

Citations

1
Correlation between vitamin D levels and blood pressure in elderly hypertensive patients with osteoporosis DOI Creative Commons

Tianlong Wu,

Zebin Lin,

Chizhen Wang

et al.

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: May 21, 2024

Objectives The association between vitamin D and blood pressure in elderly patients with hypertension complicated by osteoporosis remains unclear. objective of this study is to explore whether deficiency contributes elevated individuals both osteoporosis. Methods This represents a single-center retrospective observational investigation carried out at the Zhongshan Hospital Affiliated Xiamen University. Ambulatory pressure, bone density, levels, additional laboratory parameters were collected upon admission. ambulatory outcomes was assessed using Spearman correlation tests partial analyses. relationship changes analyzed through Generalized Additive Models, threshold analysis conducted potential thresholds. Results 139 newly diagnosed consecutively included (mean age 73 years, 84.9% female). There negative 25-(OH) D3 24 h mean systolic (mSBP), diurnal mSBP, nocturnal maximum SBP, respectively. results generalized additive model show that there nonlinear After determining critical point as 42 nmol/L, segmented linear regression used calculate effect size 95% confidence interval on sides point. When ≤42 it significantly negatively correlates h, diurnal, SBP. Conversely, when exceeds no statistically significant or mSBP. Conclusion levels

Language: Английский

Citations

0
Association Between Consumption of Foods Containing Vitamin D and All-Cause Mortality in Korea DOI
Jung Hyun Kwak, Jean Kyung Paik

Journal of Medicinal Food, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 25, 2024

Sufficient vitamin D levels are reported to be a factor in reducing various chronic diseases and resulting mortality rates. Well-dried mushrooms blue-backed fish known rich D. In this study, the association between rates intake of D-rich foods was confirmed using data from Korean Genome Epidemiological Study (KoGES). Among KoGES database, we followed up total 6844 adults who participated Ansung-Ansan cohort study recruited 2001 2002 continued for an average 16.7 years until 2018. The main findings were analyzed Cox regression analysis. During follow-up, 439 cases all-cause mortality, 149 cancer-related 91 cardiovascular confirmed. fully adjusted model, hazard ratio (HR) quartile 3 mushroom consumption 0.709 (95% confidence interval [CI], 0.525-0.958) compared with 1. addition, HRs 0.348 CI, 0.154-0.787) those quartiles 4 0.442 0.226-0.865) 0.533 0.285-0.998), respectively, conclusion, moderate related decreased risk while heightened inversely mortality.

Language: Английский

Citations

0