Elevated remnant cholesterol and the risk of prevalent major depressive disorder: a nationwide population-based study DOI Creative Commons
Shiyi Tao,

Lintong Yu,

Jun Li

et al.

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 14, 2024

Background Remnant cholesterol (RC) has received increasing attention due to its association with a variety of diseases. However, comprehensive population-based studies elucidating the relationship between RC and major depressive disorder (MDD) are limited. The current study aimed determine MDD in US adults. Methods Cross-sectional data adults complete depression information were obtained from National Health Nutrition Examination Survey (NHANES) 2005-2018. was evaluated using Patient Questionnaire (PHQ-9). Multivariate logistic regression, sensitivity analysis, spline smoothing plot method conducted explore depression. cut-off point calculated recursive partitioning analysis when segmenting effects emerged. area under receiver operating characteristic (ROC) curve (AUC), calibration curve, Hosmer-Lemeshow test, decision (DCA), clinical impact (CIC) employed evaluate performance identifying MDD. Subgroup analyses interaction tests performed whether stable different populations. Results A total 9,173 participants enrolled higher quartile tended have PHQ-9 score prevalence In fully adjusted model, positive both observed (β=0.54, 95% CI 0.26~0.82; OR=1.43, 1.15~1.78). Participants highest had 0.42-unit (β=0.42, 0.15~0.69) significantly 32% risk than those lowest (OR=1.32, 1.05~1.66). Spline further confirmed non-linear ROC (AUC=0.762), test ( χ 2 = 6.258, P =0.618), all indicated high goodness-of-fit multivariate model. DCA CIC similarly demonstrated overall net benefit for suggested that remained across subgroups unaffected by other factors diabetes, hypertension, or hyperlipidemia. Conclusion An elevated is associated prevalent among adults, especially present results management levels comorbidities may contribute alleviating occurrence

Language: Английский

Association between remnant cholesterol and the risk of 4 site-specific cancers: evidence from a cross-sectional and Mendelian randomization study DOI Creative Commons
Mengjie Li, Qi Liu, Ming Shi

et al.

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: Aug. 20, 2024

Recent studies have implicated remnant cholesterol (RC) in the etiology, progression, and prognosis of cancer. However, very few them concentrated on study precise relationship between serum RC levels cancer risk, leaving this subject unexplored. Consequently, aims to investigate association 4 site-specific cancers, employing a dual approach that combines observational mendelian randomization (MR) analysis. Based data from National Health Nutrition Examination Survey (NHANES) 1999 2020, collected from18,067 participants. To rule out confounders, utilized weighted multivariable logistic regression assessed non-linear associations using restricted cubic spline (RCS) regression, followed by two-piecewise linear regression. Sensitivity analysis conducted included subgroup analysis, multiple imputation, outlier removal, propensity score matching. strengthen causal inference, employed univariable MR The robustness reliability findings were estimated application replication meta-analysis. results demonstrated significant breast cancer, showing individuals higher logRC category had risk compared those lower (Q3 vs. Q1: OR = 1.71, 95% CI: 1.01–2.88, P 0.044). Weighted RCS revealed an inverted L-shape (P-nonlinear 0.0386, P-overall 0.010). Primary provided evidence for increased (IVW: 1.08, 1.03–1.12, 0.000951) colorectal 1.12, 1.00-1.24, 0.0476) associated with RC. meta-analysis did not support (OR 1.04, 0.95–1.13), lung 0.95, 0.88–1.03), 1.05, 0.92–1.19), prostate 1.01, 0.95–1.08). Although was observed cross-sectional analyses failed provide any evidence.

Language: Английский

Citations

1
Establishment of RNA modification regulators index predicting clinical outcomes and immune relevance of kidney cancer patients DOI Creative Commons

Gang Li,

Jingmin Cui, Shuang He

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(20), P. e39021 - e39021

Published: Oct. 1, 2024

Increasing evidence indicates that RNA modifications are misregulated in human cancers, which might be optimal targets of cancer therapy. However, important regulators kidney still need further exploration. In this study, we collected representing different types modification and identified the prognosis-related patients. We constructed a 4-gene signature index called (PRRI) by Lasso-Cox regression algorithm. found PRRI could precisely predict prognosis patients KIRC training (AUC at 3-/5-/7-years = 0.7132/0.7220/0.7283) testing cohorts 0.7141/0.7403/0.7305) two independent RCC - E-MTAB-1980 0.7036/0.7385/0.7143) KIRP 0.6203/0.6365/0.6941). Moreover, high group showed worse clinical outcome than low group. demonstrated strong robustness was related to histological grade pathologic stage, also an factor when other variables adjusted it. several immune-related pathways differentially enriched or The regulation T cell migration, has been proven immunosuppressive cell, shows enrichment Further analysis reveals highly positive correlation with activity Tregs. TIDE immune therapy revealed resist therapy, while benefit from treatment, indicating marker for predicting therapeutic response. All all, determined 4 potentially essential illustrated their mechanisms concretely. Furthermore, patients' outcomes immunotherapy response.Graphical abstract

Language: Английский

Citations

0
Associations Between Lipid Traits and Breast Cancer Risk: A Mendelian Randomization Study in African Women DOI Creative Commons
Emmanuel Owusu Ansah, Foster Kyei,

Caleb Frimpong Opoku

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 23, 2024

Abstract Backgrounds Blood lipids are associated with breast cancer. An increasing number of reports have attempted to explore the genetic connection between blood and risk developing However, observational studies can be affected by confounding factors reverse causation, which compromise reliability findings. Methods We used univariate multivariable two-sample mendelian randomization causal association Summary-level data for lipid traits were obtained from Africa Wits-INDEPTH partnership Genomic Research (AWI-Gen) (N = 10,603, 58.5% women). For cancer, we leveraged summary statistics most comprehensive Genome-wide Association Studies (GWAS) on cancer consisting 18,034 cases 22,104 controls women African ancestry. Results Our analysis suggests that genetically predicted triglycerides had a potential protective effect carcinoma (OR 0.73, 95% CI 0.56, 0.95, FDR 0.001). found no evidence elevated levels TC, HDL, LDL may TC 1.04; CI, 0.93, 1.18; FDR 0.029); HDL 1.29, 1.79, 0.008); 1.04, 0.90, 1.20, 0.036). Multivariate analysis, adjusted effects TG, LDL, attenuated observation TG also relationship cancers. Furthermore, there was subtypes. findings robust in several sensitivity analyses. Conclusions This study provides strong circulating decreased while not related among women. align both MR conducted European populations. contrast our results, some suggest increase Europeans, indicating ethnic differences profiles patients.

Language: Английский

Citations

0
Elevated remnant cholesterol and the risk of prevalent major depressive disorder: a nationwide population-based study DOI Creative Commons
Shiyi Tao,

Lintong Yu,

Jun Li

et al.

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 14, 2024

Background Remnant cholesterol (RC) has received increasing attention due to its association with a variety of diseases. However, comprehensive population-based studies elucidating the relationship between RC and major depressive disorder (MDD) are limited. The current study aimed determine MDD in US adults. Methods Cross-sectional data adults complete depression information were obtained from National Health Nutrition Examination Survey (NHANES) 2005-2018. was evaluated using Patient Questionnaire (PHQ-9). Multivariate logistic regression, sensitivity analysis, spline smoothing plot method conducted explore depression. cut-off point calculated recursive partitioning analysis when segmenting effects emerged. area under receiver operating characteristic (ROC) curve (AUC), calibration curve, Hosmer-Lemeshow test, decision (DCA), clinical impact (CIC) employed evaluate performance identifying MDD. Subgroup analyses interaction tests performed whether stable different populations. Results A total 9,173 participants enrolled higher quartile tended have PHQ-9 score prevalence In fully adjusted model, positive both observed (β=0.54, 95% CI 0.26~0.82; OR=1.43, 1.15~1.78). Participants highest had 0.42-unit (β=0.42, 0.15~0.69) significantly 32% risk than those lowest (OR=1.32, 1.05~1.66). Spline further confirmed non-linear ROC (AUC=0.762), test ( χ 2 = 6.258, P =0.618), all indicated high goodness-of-fit multivariate model. DCA CIC similarly demonstrated overall net benefit for suggested that remained across subgroups unaffected by other factors diabetes, hypertension, or hyperlipidemia. Conclusion An elevated is associated prevalent among adults, especially present results management levels comorbidities may contribute alleviating occurrence

Language: Английский

Citations

0