Broadening horizons: research on ferroptosis in lung cancer and its potential therapeutic targets

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 23, 2025

Ferroptosis is a novel form of cell death distinct from traditional mechanisms, characterized by the accumulation iron ions and production lipid peroxides. It not only affects survival tumor cells but also closely linked to changes in microenvironment. Lung cancer one leading malignancies worldwide terms incidence mortality, its complex biological mechanisms resistance make treatment challenging. Recent studies have shown that ferroptosis plays key role onset progression lung cancer, with intricate regulatory influencing development response therapy. As research into deepens, related molecular pathways, such as glutamate metabolism, antioxidant defense, been gradually revealed. However, clinical practice, ferroptosis-based therapeutic strategies for are still their early stages. Challenges remain, including incomplete understanding specific ferroptosis, insufficient on factors, limited insight interactions within Therefore, effective modulation enhance remains an urgent issue. This review summarizes analyzes factors interaction microenvironment, further explores potential targeting ferroptosis. By synthesizing latest research, this paper aims provide new perspectives directions treatment, goal advancing applications.

Language: Английский

Combined MR Volumetry and T2* Relaxometry Reveals the Olfactory System as an Iron-Dependent Structure Affected by Radiation

Neurology International, Journal Year: 2025, Volume and Issue: 17(4), P. 53 - 53

Published: April 8, 2025

Background/Objectives: Radiation therapy can often lead to structural and functional changes in the brain resulting radiation-induced injury. This study investigates MRI-detectable effects of whole-brain irradiation across all neuroanatomical structures adult mice, with a specific focus on T2* MRI measurements, evaluate regions that may be particularly sensitive iron accumulation. Methods: One year following or sham treatment, mice were imaged 7T regional volume relaxation times more than 652 using DSURQE mouse atlas. Results: Statistical analysis identified 301 altered respect 85 showing significant differences relative control group (p < 0.05). Further data refinement, including consolidation redundant, bi-lateral revealed 18 subregions both T2*. The refinement most represented system was olfactory (8/18 regions, 44%). also showed pronounced greatest correlation between two metrics. Conclusions: These findings are suggestive ionizing radiation cause disruption coincides potential

Language: Английский

The role of ACSL4 in stroke: mechanisms and potential therapeutic target

Molecular and Cellular Biochemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

Stroke, as a neurological disorder with poor overall prognosis, has long plagued the patients. Current stroke therapy lacks effective treatments. Ferroptosis emerged prominent subject of discourse across various maladies in recent years. As an emerging therapeutic target, notwithstanding its initial identification tumor cells associated brain diseases, it lately been recognized pivotal factor pathological progression stroke. Acyl-CoA synthetase long-chain family member 4 (ACSL4) is potential target and biomarker catalytic unsaturated fatty acids mediating ferroptosis Specifically, upregulation ACSL4 leads to heightened accumulation lipid peroxidation products reactive oxygen species (ROS), thereby exacerbating neuronal cells. present tissues involved multiple pathways ferroptosis. At present, pharmacological mechanisms targeting inhibit have found many drugs, but molecular are still exploratory stage. This paper introduces physiopathological mechanism current status research crosstalk epigenetics, summarizes application modern pharmacology research, discusses value field

Language: Английский