Mechanical characterization of the human femoral vein wall and its valves DOI Creative Commons
Kerstin Lebahn, Jonas Keiler, W. J. Schmidt

et al.

Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials, Journal Year: 2025, Volume and Issue: 165, P. 106938 - 106938

Published: Feb. 10, 2025

For the development of stent-based intraluminal prostheses to treat chronic venous insufficiency, comprehensive knowledge morphometric and mechanical parameters femoral veins (FV) is crucial for an optimized implant design. These data essential as input material models numerical simulations valves prostheses. However, on properties native/unfixed FV tissue are scarce. Unfixed native tissue, though, has limited availableness durability due progressing decay. To address these challenges, this study aimed determine stress-strain behavior compliance from specimens human its body donations compared chemically fixed material. A large set been generated in tensile tests with a total 313 wall 78 valve leaflet different fixation groups 41 donations. Tensile testing was conducted at cut rectangular longitudinal well circumferential direction vein walls one specific leaflets. Young's moduli E1 E2 two differently defined strain regions, strength Rm elongation break were determined. Additionally, measurements performed whole, unfixed segments using optical coherence tomography vessel diameter increasing intravascular pressure 20 240 mmHg. Significant differences found between fixations (exemplary modulus direction: E1, = 5.7 ± 5.1 N/mm2, FA 13.1 11.9 PFA 2.3 1.0 N/mm). distinct anisotropy could only be detected when comparing direction. Resultant mean values over all measuring positions analyzed stages range 18.16 3.78 %/100 mmHg showed decrease pressure. Fixation (FA, PFA) alters elastomechanical behavior, but still similar order magnitude considering naturally occurring variability. Thus, appears appropriate use ex vivo testing. The provided (longitudinal circumferential) leaflets may serve basis models, e.g. artificial valves.

Language: Английский

Mechanical characterization of the human femoral vein wall and its valves DOI Creative Commons
Kerstin Lebahn, Jonas Keiler, W. J. Schmidt

et al.

Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials, Journal Year: 2025, Volume and Issue: 165, P. 106938 - 106938

Published: Feb. 10, 2025

For the development of stent-based intraluminal prostheses to treat chronic venous insufficiency, comprehensive knowledge morphometric and mechanical parameters femoral veins (FV) is crucial for an optimized implant design. These data essential as input material models numerical simulations valves prostheses. However, on properties native/unfixed FV tissue are scarce. Unfixed native tissue, though, has limited availableness durability due progressing decay. To address these challenges, this study aimed determine stress-strain behavior compliance from specimens human its body donations compared chemically fixed material. A large set been generated in tensile tests with a total 313 wall 78 valve leaflet different fixation groups 41 donations. Tensile testing was conducted at cut rectangular longitudinal well circumferential direction vein walls one specific leaflets. Young's moduli E1 E2 two differently defined strain regions, strength Rm elongation break were determined. Additionally, measurements performed whole, unfixed segments using optical coherence tomography vessel diameter increasing intravascular pressure 20 240 mmHg. Significant differences found between fixations (exemplary modulus direction: E1, = 5.7 ± 5.1 N/mm2, FA 13.1 11.9 PFA 2.3 1.0 N/mm). distinct anisotropy could only be detected when comparing direction. Resultant mean values over all measuring positions analyzed stages range 18.16 3.78 %/100 mmHg showed decrease pressure. Fixation (FA, PFA) alters elastomechanical behavior, but still similar order magnitude considering naturally occurring variability. Thus, appears appropriate use ex vivo testing. The provided (longitudinal circumferential) leaflets may serve basis models, e.g. artificial valves.

Language: Английский

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