Hydrogel-Based Biomaterials: A Patent Landscape on Innovation Trends and Patterns

Gels, Journal Year: 2025, Volume and Issue: 11(3), P. 216 - 216

Published: March 20, 2025

The hydrogel patent landscape is characterized by rapid growth and diverse applications, particularly in the biomedical field. Advances material science, chemistry, novel manufacturing techniques, a deeper understanding of biological systems have revolutionized development hydrogel-based biomaterials. These innovations led to enhanced properties expanded regenerative medicine, drug delivery, tissue engineering, positioning hydrogels as pivotal future engineering. In this study, an updated for biomaterials proposed. By analyzing documents, classifications, jurisdictions, applicants, overview provided characterize key trends insights. analysis reveals that hydrogel-related patents are experiencing significant growth, with strong focus on applications. Foundational research formation remains dominant, 96,987 documents highlighting advancements crosslinking polysaccharide-based materials, biologically active wound care regeneration. United States China lead filings, notable contributions from Europe high number international under Patent Cooperation Treaty (PCT) system, reflecting global interest technologies. Moreover, emerging include biodegradable designed regeneration, wearable sensors, advanced therapeutic applications such chemoembolization agents vascular defect treatments. increasing integration bioactive elements driving multifunctional tailored specific medical environmental needs. While study focuses trends, alignment between patenting activities underscores role bridging scientific discoveries industrial Future could explore citation impact assessments gain insights into technological significance inventions. Finally, selection top 10 recent granted field presented illustrative example innovation area illustrate cutting-edge innovations.

Language: Английский

---

Efficacy of Three-Dimensional Bioactive Composites in Long Bone Repair with Photobiomodulation

Materials, Journal Year: 2025, Volume and Issue: 18(8), P. 1704 - 1704

Published: April 9, 2025

Different treatments have been proposed for morphofunctional bone repair; however, they are not always efficient and limitations. In this experimental study, we present matrix composites with a possible synergistic effect acting scaffolds growth use of photobiomodulation (PBM) to accelerate tissue repair. Thus, the objective was evaluate PBM in repair long (tibia) rats filled biomimetic collagen matrices nanohydroxyapatite heterologous fibrin biopolymer (FB). Forty-eight were distributed into eight groups (n = six each): Blood Clot (BC), + (BCP), Matrix (M), (MP), Fibrin Biopolymer (FB), (FBP), FB (MFB), (MFBP). A 2.0 mm defect created proximal third left tibia. The BCP, MP, FBP, MFBP underwent during surgery maintained twice week until euthanasia at 42 days. Microcomputed tomography (micro-CT), histomorphological histomorphometric analyses performed. Micro-CT analysis revealed that influenced cortical interposition between remnant newly formed bone. Histologically, no exacerbated inflammatory focus or foreign body-type granulomatous reaction observed any group; vast collagenous more oriented thicker spatial conformation PBM-treated groups. Histomorphometrically, showed significantly higher values compared other Specifically, BC group presented mean density 68.33 ± 7.394, while BCP MP 99.83 11.87 99.67 20.58, respectively (p < 0.05). Qualitative fibers indicated enhanced organization maturation This study concluded association bones rats, biopolymer, results contribute improvement growth, together scaffolds.

Language: Английский

---

An Injectable Kartogenin-Incorporated Hydrogel Supports Mesenchymal Stem Cells for Cartilage Tissue Engineering

Bioengineering, Journal Year: 2025, Volume and Issue: 12(5), P. 434 - 434

Published: April 22, 2025

Background: Cartilage defects and injuries often lead to osteoarthritis, posing significant challenges for cartilage repair. Traditional treatments have limited efficacy, necessitating innovative therapeutic strategies. This study aimed develop an injectable hydrogel-based tissue engineering construct enhance regeneration by combining mesenchymal stem cells (MSCs) the small molecule drug kartogenin (KGN). Methods: An hydrogel was synthesized crosslinking carboxymethyl chitosan (CMC) with aldehyde-modified cellulose nanocrystals (DACNCs). KGN incorporated into during achieve sustained release. Three hydrogels varying CMC/DACNC molar ratios (MR = 0.11, 0.22, 0.33) were developed characterized their structural, mechanical, biocompatible properties. The optimal ratio further evaluated its ability support MSC viability differentiation in vitro. Additionally, signaling pathways (TGF-β, FOXO, PI3K-AKT) investigated elucidate underlying mechanisms. In vivo efficacy assessed using a rabbit femoral trochlear defect model. Results: higher exhibited increased compressive modulus, reduced swelling rate, superior biocompatibility, effectively promoting Signaling pathway analysis revealed activation of TGF-β, PI3K-AKT pathways, suggesting enhanced chondrogenic potential. experiments demonstrated that KGN-MSC-encapsulated significantly improved Conclusions: hydrogel, combined MSCs, synergistically both vitro vivo. highlights potential this as promising scaffold engineering, offering novel approach injuries.

Language: Английский

---

Current Utilization of Gel-Based Scaffolds and Templates in Foot and Ankle Surgery—A Review

Gels, Journal Year: 2025, Volume and Issue: 11(5), P. 316 - 316

Published: April 24, 2025

As tissue engineering and regenerative medicine (TERM) continues to revolutionize surgery, there is also growing interest in applying these advancements foot ankle surgery. The purpose of this article provide a comprehensive review the types gel scaffolds templates, their applications challenges with current utilization, future directions TERM With multiple compelling scaffold prospects across numerous natural, synthetic, hybrid polymers currently utilized TERM, promising results have been described treatment osteoarthritis (OA) osteochondral lesions (OCLs). However, concerns material biocompatibility, structural integrity, feasibility during degradation still exist limit extent utilization. researchers continue develop enhanced formulations that address issues, are many opportunities increase

Language: Английский

---