Urinary mycoestrogens and gestational weight gain in the UPSIDE pregnancy cohort DOI Creative Commons
Carolyn Waugh Kinkade, Zorimar Rivera‐Núñez, Anita Brinker

et al.

Environmental Health, Journal Year: 2024, Volume and Issue: 23(1)

Published: Nov. 21, 2024

Zearalenone (ZEN), a secondary metabolite of Fusarium fungi, is one the most common mycotoxins in global food supplies such as cereal grains and processed food. ZEN its metabolites are commonly referred to mycoestrogens, due their ability directly bind nuclear estrogen receptors α (ER-α) β (ER-β). Zeranol, synthetic mycoestrogen, administered U.S. cattle growth promoter. Despite widespread human exposure ample evidence adverse reproductive impacts vitro vivo, there has been little epidemiological research on health during pregnancy. The objective our study was examine associations between gestational weight gain (GWG). Urine samples were collected each trimester from pregnant participants UPSIDE cohort (n = 286, Rochester, NY, USA). High performance liquid chromatography high-resolution tandem mass spectrometry used quantify concentrations well ∑mycoestrogens (composite sum metabolites; ng/ml). Maternal weights at clinical visits abstracted medical records. We fitted longitudinal models specific-gravity adjusted, log-transformed relation total GWG (kilograms) rate (kilograms/week). additionally examined risk excessive (in Institute Medicine guidelines) considered effect modification by fetal sex. detected > 93% 95% samples, respectively. Mycoestrogen positively associated with (ZEN β:0.50 kg; 95%CI: 0.13, 0.87) β:0.20 kg/week; 0.01, 0.03). Associations tended be stronger among carrying male (versus female) fetuses results robust adjustment for diet. pregnancy may contribute greater GWG. Future needed understand potential influences downstream maternal offspring health.

Language: Английский

Associations of prenatal exposure to per- and polyfluoroalkyl substances and fetal sex hormones in the Guangxi Zhuang Birth Cohort Study: Greater effect of long-chain PFAS DOI Creative Commons
Qian Liao,

Huishen Huang,

Peng Tang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 272, P. 116054 - 116054

Published: Feb. 3, 2024

Fetal sex hormone homeostasis disruption could lead to reproductive and developmental abnormalities. However, previous studies have reported inconsistent findings regarding the association of maternal per- polyfluoroalkyl substances (PFAS) exposure with fetal levels. A total 277 mother-infant pairs from Guangxi Zhuang Birth Cohort Study between 2015 2019 were selected. We quantified nine PFAS in serum early pregnancy, detected three hormones, namely, estradiol (E2), progesterone (P4) testosterone (TT), cord blood. The generalized linear model (GLM) Bayesian kernel machine regression (BKMR) used for single- multiple-exposure analyses, respectively. In GLM, there was no significant an individual any level or E2/TT ratio, but a negative perfluorododecanoic acid (PFDoA) P4 levels female infants observed after stratification by sex. BKMR, mixture positively associated E2 same main contributors, i.e., perfluoroundecanoic (PFUnA). And mixtures not TT After infant sex, positive associations ratio only male infants, PFUnA. There which PFUnA contributor; reverse PFDoA contributor. This study suggested that prenatal is long-chain may play important role this association. Furthermore, differences need additional attention.

Language: Английский

Citations

4
Maternal per- and polyfluoroalkyl substances exposure, cord blood lipidomics and infant anthropometry: A mediation analysis DOI
Lan Yang,

Likang Li,

Honglei Ji

et al.

Environmental Research, Journal Year: 2025, Volume and Issue: 271, P. 121074 - 121074

Published: Feb. 7, 2025

Language: Английский

Citations

0
The Association Between Per- and Polyfluoroalkyl Substances Exposure and Thyroid Hormones in Men and Non-Pregnant Women: A Systematic Review and Meta-Analysis DOI Creative Commons
Bin Zhang, Miao Zhao,

Xiangru Cong

et al.

Toxics, Journal Year: 2025, Volume and Issue: 13(3), P. 214 - 214

Published: March 14, 2025

Studies have shown that per- and polyfluoroalkyl substances (PFAS) may impact thyroid function in human health. While the consistency between PFAS exposure health effects pregnant women has been validated, on men non-pregnant remains inconclusive. To address this, a meta-analysis was carried out this paper, with 14 eligible studies retrieved from Embase, PubMed, Web of Science were published up to 2 June 2024, focusing relationship its effect hormone levels body. The indexes analyzed included stimulating (TSH), triiodothyronine (T3), thyroxine (T4), free T3 (FT3), T4 (FT4). estimated value (β) corresponding confidence interval (95% CI) extracted literature. A heterogeneity test out, sensitivity analysis publication bias using Stata 18.0. results revealed women, PFOA positively correlated FT3 (β = 0.011, 95% CI 0.001, 0.02, I2 13.4). However, no significant associations found other hormones. subgroup further indicated correlations more adolescents, both America Europe.

Language: Английский

Citations

0
Association between prenatal perfluorinated compounds exposure and risk of pregnancy complications: A meta-analysis DOI Creative Commons

Liya Pang,

Mei Li,

Abdoulie Dukureh

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 272, P. 116017 - 116017

Published: Jan. 29, 2024

Per- and polyfluoroalkyl substances (PFASs) have been shown to be persistent bioaccumulative. An elevated danger of pregnancy complications perhaps connected with exposure PFASs, but the potential effects remain elusive. The objective this study is investigate possible association between PFASs complications, drawing upon existing evidence.

Language: Английский

Citations

2
Ultra-processed Food Intake During Pregnancy and its Impact on Maternal Diet Quality and Weight Change: A Systematic Review of Observational Studies DOI
Buket Akyakar, Hilal Yıldıran, Vassiliki Bountziouka

et al.

Current Nutrition Reports, Journal Year: 2024, Volume and Issue: 13(4), P. 800 - 814

Published: Oct. 7, 2024

Language: Английский

Citations

1
Gestational exposure to PFAS, the “Forever Chemicals,” May Have “Forever” Health Impacts DOI Creative Commons
Erin S. LeBlanc

The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 24, 2024

Journal Article Accepted manuscript Gestational exposure to PFAS, the "Forever Chemicals," May Have "Forever" Health Impacts Get access Erin LeBlanc, MD, MP Kaiser Permanente Center for Research NW, Portland, OR, US Corresponding author: S. MPH Contact Information: 3800 N Interstate Ave, Portland OR 97227, Email: [email protected] Phone: (503) 335-2400 https://orcid.org/0000-0002-4067-3432 Search other works by this author on: Oxford Academic Google Scholar The of Clinical Endocrinology & Metabolism, dgae743, https://doi.org/10.1210/clinem/dgae743 Published: 24 October 2024 history Received: 04 September Revision received: 14 Accepted: 22

Language: Английский

Citations

0
Urinary mycoestrogens and gestational weight gain in the UPSIDE pregnancy cohort DOI Creative Commons
Carolyn Waugh Kinkade, Zorimar Rivera‐Núñez, Anita Brinker

et al.

Environmental Health, Journal Year: 2024, Volume and Issue: 23(1)

Published: Nov. 21, 2024

Zearalenone (ZEN), a secondary metabolite of Fusarium fungi, is one the most common mycotoxins in global food supplies such as cereal grains and processed food. ZEN its metabolites are commonly referred to mycoestrogens, due their ability directly bind nuclear estrogen receptors α (ER-α) β (ER-β). Zeranol, synthetic mycoestrogen, administered U.S. cattle growth promoter. Despite widespread human exposure ample evidence adverse reproductive impacts vitro vivo, there has been little epidemiological research on health during pregnancy. The objective our study was examine associations between gestational weight gain (GWG). Urine samples were collected each trimester from pregnant participants UPSIDE cohort (n = 286, Rochester, NY, USA). High performance liquid chromatography high-resolution tandem mass spectrometry used quantify concentrations well ∑mycoestrogens (composite sum metabolites; ng/ml). Maternal weights at clinical visits abstracted medical records. We fitted longitudinal models specific-gravity adjusted, log-transformed relation total GWG (kilograms) rate (kilograms/week). additionally examined risk excessive (in Institute Medicine guidelines) considered effect modification by fetal sex. detected > 93% 95% samples, respectively. Mycoestrogen positively associated with (ZEN β:0.50 kg; 95%CI: 0.13, 0.87) β:0.20 kg/week; 0.01, 0.03). Associations tended be stronger among carrying male (versus female) fetuses results robust adjustment for diet. pregnancy may contribute greater GWG. Future needed understand potential influences downstream maternal offspring health.

Language: Английский

Citations

0